联系方式

  • 职  称: 教授
  • 所在部门: 细胞生物学研究所
  •  办公室: 逸夫生物楼508
  • 联系电话: 0931-8915399
  • 传真号码:
  • 电子邮件: housw@lzu.edu.cn
  • 个人主页:
学习经历

1986.9-1990.6  甘肃省成县师范学校,中专;

1990.9-1994.6  西北师范大学生物系,学士;

1994.9-1997.8  中科院昆明植物研究所,硕士,导师陈宗莲研究员;

1999.9-2004.5  兰州大学生命科学学院,细胞生物学博士学位,导师贾敬芬教授;

2002.1-2003.1  英国剑桥大学植物科学系,访问学者,导师 Alex Webb 教授;

2005.3-2008.2  中科院近代物理研究所,博士后,合作导师李文建研究员。

1986.9-1990.6  Normal School of Chengxian, Gansu Province

1990.9-1994.6  B.S., College of Life Sciences, Northwest Normal University

1994.9-1997.8  M.S., Kunming Institute of Botany, Chinese Academy of Sciences,Supervisor Professor Zonglian Chen

1999.9-2004.5  Ph.D., School of Life Sciences, Lanzhou University, Supervisor Professor Jingfen Jia

2002.1-2003.1  Visiting scholar, Plant Sciences Department, Cambridge University, Supervisor Professor Alex Webb

2005.3-2008.2  Postdoctor, Institute of Modern Physics, Chinese Academy of Sciences, Cooperation Supervisor Researcher Wenjian Li

 

工作经历

1997.8-2000.5   兰州大学生命科学学院助教;

2000.6-2004.5   兰州大学生命科学学院讲师;

2004.6-2009.5   兰州大学生命科学学院副教授,硕士研究生导师;

2009.6-现在     兰州大学生命科学学院教授,博士研究生导师。

1997.8-2000.5    Teaching assistant, School of Life Sciences, Lanzhou University, China

2000.6-2004.5    Lecturer, School of Life Sciences, Lanzhou University, China

2004.6-2009.5    Associate professor, School of Life Sciences, Lanzhou University, China

2009.6-Present   Professor, School of Life Sciences, Lanzhou University, China

 

社会工作

《植物学报》第七届编辑委员会责任编委,中国细胞生物学学会第九届理事,中国植物学会外事处副主任,中国细胞生物学会植物器官发生分委员会委员、细胞生物学教学与普及工作委员会委员,中国植物生理与分子生物学学会植物激素生物学专业委员会委员甘肃省植物学会理事,细胞活动与逆境适应教育部重点实验室副主任,兰州大学生命科学学院副院长。

研究方向

1、植物蛋白磷酸酶1(PP1)的功能通过遗传和分子生物学方法,在国际上首次发现拟南芥蛋白磷酸酶 PP1 调控赤霉素信号转导、生长素的极性运输和光信号通路。磷酸酶TOPP4通过对GA信号通路抑制蛋白DELLA去磷酸化修饰,促进其降解,正调控赤霉素信号通路(PLoS Genetics2014);证明TOPP4可以对生长素运输蛋白PIN1去磷酸化,调控生长素在表皮细胞内外的极性分布,控制扁平细胞的形态建成(Plant Physiology,2015);发现TOPP4与phyB在红光下对PIF5进行磷酸化修饰,调节PIF5的降解,参与了植物的光形态建成(Plant Physiology,2016。目前主要深入阐明PP1调控植物生长发育机理,包括研究PP1的调节亚基、PP1参与各种逆境响应的分子机理,以及PP1在重要作物中的应用等。

2、气孔发育的分子机理研究拟南芥、水稻表皮细胞发育图式和形态建成的内在调控因子和信号转导机制,已经克隆到多个参与气孔及表皮细胞形态建成的基因。例如发现植物甾醇早期合成途径调控气孔系细胞的命运维持和决定,参与气孔的图式发育(Plant Journal2013;发现RNA聚合酶II的亚基NRPB3、NRPB2对于气孔图式和分化是非常重要的,NRPB3通过与FAMA和ICE1直接作用,扮演了气孔图式发育过程中转录因子信号接受器的角色,这一策略与肌肉细胞的发育机理类似(Development2016)。目前主要开展双子叶和单子叶植物(水稻和玉米)气孔发育的网络调控,以及其在作物中的应用。

1. The functions of protein phosphatase I (PP1) in plant

Using genetic and molecular biology approaches, our research group illustrated that protein phosphatase PP1 regulates gibberellin signal transduction, auxin polar transport and light signaling pathways in Arabidopsis for the first time. The phosphatase TOPP4 dephosphorylates DELLA, a key GA signaling pathway inhibitor, and promotes its degradation, positively regulating GA signaling pathway (PLOS Genetics, 2014). TOPP4 also dephosphorylates PIN1, and regulates its polar distribution in the pavement cell, controlling pavement cell morphogenesis (Plant Physiology, 2015). In addition, TOPP4 dephosphotylates PIF5, and promotes its degradation during plant photomorphogenesis (Plant Physiology, 2016). At present, we focus on the PP1 mediated molecular mechanisms underlie plant growth and development and the function of PP1 regulatory subunits.

2. The molecular mechanisms of stomata development

Through forward and reverse genetic approaches, we cloned several genes controlling epidermal cell morphogenesis and stomotal patterning in Arabidopsis and rice. For example, early sterol synthesis pathway is required for cell fate commitment and maintenance in stomatal lineage (Plant Journal, 2013); NRPB3 and NRPB2, the subunits of RNA polymerase II, are essential for stomatal patterning and differentiation. NRPB3 receives signals from transcription factors during stomatal patterning development by directly interacting with FAMA and ICE1. This mechanism is similar to that in muscle cell differentiation (Development, 2016). At present, we are studying the regulatory mechanisms of stomatal development in rice and maize.

 

项目成果

主持8项国家自然科学基金,参加2项科技部“973”计划项目、4项农业部转基因专项,主持3项省基金项目等。部分项目:

1、农业部重大专项,2016ZX08009003-002,抗逆和抗除草剂关键基因克隆及功能验证,2016/01-2020/12,201万元,参加/主持

2、国家自然科学基金面上项目,31670185,水稻F-box蛋白SFC通过泛素化降解途径调控气孔图式发育,2017/01-2020/12,62万元,主持

3、国家自然科学基金面上项目,31470372,TOPP4与WAT1相互作用调控赤霉素和生长素信号通路互作,2015/01-2018/12,90万,主持

4、国家自然科学基金面上项目,31271460,TIR-NB-LRR蛋白调控乙烯合成和细胞扩展的分子机理,2013/01-2016/12,80万,主持

5、国家自然科学基金重大研究计划培育项目,91017002,拟南芥蛋白磷酸酶1调控赤霉素和生长素信号转导机理,2011/01-2013/12,60万,主持

6、国家自然科学基金面上项目,31070247,一个新的拟南芥PP1磷酸酶(PIPE)调节赤霉素信号转导通路的研究,2011/01-2013/12,33万,主持

7、国家自然科学基金面上项目,30670124,拟南芥气孔发育图式基因筛选与鉴定研究,2007/01-2009/12,27万,主持

8、国家自然科学基金青年科学基金项目,30300029,用增强子诱捕法克隆与分析拟南芥保卫细胞的功能基因,2004/01-2006/12,19万,主持

9、科技部“973 计划”项目,2011CB915401,高等植物蛋白的重要修饰过程与调控机制,谢旗教授主持,2011/01-2015/12,45万元,参加

10、科技部“973 计划”项目,2009CB941501,植物器官特征决定的遗传和表观遗传调控网络,曹晓风院士主持,2009/01-2013/12,80 万元,参加

荣誉、获奖

1、教育部“长江学者奖励计划”特聘教授(2017年)

2、国务院政府特殊津贴(2016年)

3、兰州大学优秀博士学位论文指导教师(2016年)

4、甘肃省优秀博士学位论文指导教师(2015年)

5、教育部新世纪优秀人才支持计划(2006年);

6、甘肃省自然科学二等奖(2008年);

7、陕西省科学技术奖二等奖(2006年);

8、兰州大学隆基中青年教师教学骨干奖(2009年);

9、兰州大学“三育人”先进个人(2007年);

10、兰州大学第二届“教学新秀奖”(2000年)。

教学及指导研究生情况

主讲本科生主干基础课《细胞生物学》课程,研究生《植物细胞信号转导专题》、《博士生前沿进展讲座——细胞生物学专业》等课程,曾讲授研究生《细胞信号转导进展》和《专业英语》、本科生《细胞信号转导》和《细胞生物学实验》。已经毕业并获得博士学位研究生10位、硕士学位研究生54位,指导70余名本科生毕业论文。有1位博士生获得甘肃省第二届优秀博士学位论文奖(秦倩倩),1位博士生获得兰州大学优秀博士学位论文奖(陈亮)。毕业研究生去向有国外著名大学博士后、博士生,国内重要大学、科研、教学以及企业等单位的工作人员。

研究生主要招生方向植物细胞信号转导。

欢迎有志于细胞科学研究的学子报考!

欢迎师资、研究人员和博士后加盟!

发表论文及专著

主要发表的论文(*通讯作者):

Cui Y, Hu C, Zhu Y, Cheng K, Li X, Wei Z, Xue L, Lin F, Shi H, Yi J, Hou S, He K, Li J, Gou X*. 2018. CIK receptor kinases determine cell fate specification during early anther development in Arabidopsis. Plant Cell, DOI: https://doi.org/10.1105/tpc.17.00586

Hu C, Zhu Y, Cui Y, Cheng K, Liang W, Wei Z, Zhu M, Yin H, Zeng Li, Xiao Y, Lv M, Yi J, Hou S, He K, Li J, Gou X*. 2018. A group of receptor kinases are essential for CLAVATA signaling to maintain stem cell homeostasis. Nature Plants, 4: 205-211

Zheng H, Zhang F, Wang SL, Su YH, Ji XR , Jiang PF, Chen RH, Hou SW, and Ding Y*. 2018. MLK1 and MLK2 coordinate RGA and CCA1 activity to regulate hypocotyl elongation in Arabidopsis thaliana. Plant Cell, 30: 67-82

Huang BY, Qian PP, Gao N, Shen J, Hou SW*. 2017. Fackel interacts with gibberellic acid signaling and vernalization to mediate flowering in Arabidopsis. Planta, 245(5): 939-950

Zhou WQ, Wang YC,  Wu ZL, Luo L, Liu P, Yan LF, Hou SW*. 2016. Homologs of SCAR/WAVE complex components are required for epidermal cell morphogenesis in rice. Journal of Experimental Botany, 67 (14): 4311-4323

Chen L, Guan LP, Qian PP, Xu F, Wu ZL, Wu YJ, He K, Gou XP, Li J, Hou SW*. 2016. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 143: 1600-1611

Yue J, Qin QQ, Meng SY, Jin HT, Gou XP, Li J, Hou SW*. 2016. TOPP4 regulates the stability of Phytochrome Interacting Factor 5 during photomorphogenesis in Arabidopsis. Plant Physiology, 170(3), 1381-1397

Wu Y, Xun Q, Guo Y, Zhang J, Cheng K, Shi T, He K, Hou S, Gou X, Li J*. 2016. Genome-wide expression pattern analyses of the Arabidopsis leucine-rich repeat receptor-like kinases. Molecular Plant, 9(2): 289-300

Guo XL, Qin QQ, Yan J, Niu YL, Huang BY, Guan LP, Li Y, Ren DT, Li J,  Hou SW*. 2015. TYPE-ONE PROTEIN PHOSPHATASE4 regulates pavement cell interdigitation by modulating PIN-FORMED1 polarity and trafficking in Arabidopsis. Plant Physiology, 167: 1058–1075

Han B, Chen L, Wang J, Wu ZL, Yan LF, Hou SW*. 2015. Constitutive Expresser of Pathogenesis Related Protein 1 is required for pavement cell morphogenesis in Arabidopsis. PLOS One,  DOI:10.1371/journal.pone.0133249, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133249

Yang JX, Yan LF, Song YJ, Chai CC, Song LL, Guan LP,  Hou SW*. 2015. New roles for the Arabidopsis TAO1 gene besides disease resistance. Russ J Plant Physl, 62, 542–550

Zhou WQ, Wu ZL, Zhang YC, Wu DL, Liu D, Wang YC, Gao QX, Dang BR, Li WJ, Hou SW*. 2015. Stable inheritance of excellent agricultural traits induced by 12C6+ heavy-ions in lentil (Lens culinaris Medik.). Czech J. Genet. Plant Breed, 51, 29–35

Wang W, Zhang J, Qin QQ, Yue J, Huang BY, Xu XF, Yan LF, Hou SW*. 2014. The six conserved serine/threonine sites of REPRESSOR OF ga1-3 protein 1 are important for its functionality and stability in gibberellin signaling in Arabidopsis. Planta, 240: 763779

Qin QQ, Wang W, Guo XL, Yue J, Huang Y, Xu XF, Li J, Hou SW*. 2014. Arabidopsis DELLA protein degradation is controlled by a type-one protein phosphatase, TOPP4. PLOS Genetics, 10(7): e1004464. doi:10.1371/journal.pgen.1004464. http://www.plosgenetics.org/doi/pgen.1004464

Yan LF, Cheng X, Jia RL, Qin QQ, Guan LP, Du H, Hou SW*. 2014. New phenotypic characteristics of three tmm alleles in Arabidopsis thaliana. Plant Cell Reports, 33: 719–731

Hu ZH,  Xu F, Guan LP,  Qian PP,  Liu YQ, Zhang HF, Huang Y, Hou SW*. 2014. The tetratricopeptide repeat-containing protein Slow Green1 is required for chloroplast development in Arabidopsis. Journal of Experimental Botany, 65: 1111–1123

Qian PP, Han B, Forestier E, Hu ZH, Gao N, Lu WW, Schaller H, Li J, Hou SW*. 2013. Sterols are required for cell fate commitment and maintenance of the stomatal lineage in Arabidopsis. The Plant Journal, 74:1029–1044

Guo XL, Lu WW, Ma YR, Qin QQ, Hou SW*. 2013. The BIG gene is required for auxin-mediated organ growth in Arabidopsis. Planta, 237: 1135-1147  

Luo L, Zhou WQ, Liu P, Li CX, Hou SW*. 2012. The development of stomata and other epidermal cells on the rice leaves. Biologia Plantarum, 56(3): 521-527  

Qian PP, Hou SW*, Guo GQ. 2009. Molecular mechanisms controlling pavement cell shape in Arabidopsis leaves. Plant Cell Reports, 28: 1147-1157

Wu DL, Hou SW*, Qian PP, Sun LD, Zhang YC, Li WJ. 2009. Flower color chimera and abnormal leaf mutants induced by 12C6+ heavy ions in Salvia splendens Ker- Gawl. Scientia Horticulturae, 121: 462-467

Sun LD, Hou SW*, Wu DL, Zhang YC. 2008. Rapid clonal propagation of Zygophyllum xanthoxylon (Bunge) Maxim., an endangered desert forage species. In Vitro Cellular Development Biology - Plant. 44: 396-400

Dodd AN, Jakobsen MK, Baker AJ, Tezerow A, Hou SW, Laplaze L, Barrot L, Poethig RS, Haseloff J, Webb AR. 2006. Time of day modulates low-temperature Ca2+ signals in Arabidopsis. The Plant Journal, 48:962-973

He WT, Hou SW*, Wang CY. 2006. Callus induction and high-frequency plant regeneration from hypocotyl and cotyledon explants of Arctium lappa L. In Vitro Cellular and Development Biology-Plant, 42(5): 411-414

He WT, Hou SW*, Wang CY. 2006. An efficient in vitro method for mass propagation of Potentilla potaninii Wolf. In Vitro Cellular and Development Biology-Plant, 42(5): 415-417 

Hou SW*, Jia JF. 2005. In vitro regeneration of Perilla frutescens from hypocotyl and cotyledon explants. Biologia Plantarum, 49: 129-132

Hou SW*, Jia JF. 2004. High frequency regeneration from Astragalus melilotoides hypocotyl and stem explants via somatic embryogenesis and organogenesis. Plant Cell Tissue and Organ Culture, 2004, 79: 95-100 

Hou SW*, Jia JF. Plant regeneration from protoplasts isolated from embryogenic calli of the forage legume Astragalus melilotoides Pall. Plant Cell Reports, 2004, 22: 741-46

 

编著教材:

细胞生物学实验(第4版),主编:王崇英,侯岁稳,高欢欢。高等教育出版社,2017。

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