Contact

  • Title: Professor
  • Department: Institute of Cell Biology
  • Address: 1012 Yifu Biology Building
  • Tel:
  • Fax:
  • Email: bocheng@lzu.edu.cn
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Bio

2009-2013,  Research fellow in the Univ. of Michigan/Howard Hughes Medical Institute

2013-2016,  Professor of Cell Biology in Lanzhou Univ.,  Master's supervisor

2016-  ,  Professor of Cell Biology in Lanzhou Univ.,  Master's and Doctoral supervisor

Academic Appointments

Bachelor in Biochemistry and Molecular Biology,  Nankai Univ., PRC, 2000

Master in Biochemistry and Molecular Biology,   Nankai Univ., PRC, 2003

Ph.D. in Molecular and Cellular Biology,      Univ. of Iowa, USA, 2008

Administrative Appointments

 

 

 

 

 

 

 

Honors & Awards
Funding

Current Research Interests:

1. Molecular mechanisms of Polycomb repressive complexes in transcriptional regulation in mouse embryonic stem cells

2. Molecular mechanisms of transcription elongation control

3. Epigenetic regulation during tumorigenesis and development of multiple types of carcinoma

4. Mechanisms of epigenetic repression of endogenous retroviruses

 

Research Fundings:

1. Three National Natural Science Foundation of China grants

2. A few of the Fundamental Research Funds for the Central Universities

Publications

Representative peer reviewed articles:

1. Controlling the spatiotemporal expression of germ line specific genes by PRC1.6 complex. Sun X., Li H, Wang J, Cheng B*. (corresponding author) (Invited article, cover story) Hereditas (Beijing), 2019, 41(4): 271-284. DOI: 10.16288/j.yczz.18-332

2. Activatable Smart Nanoprobe for Sensitive Endogenous MMP2 Detection and Fluorescence Imaging Guided Phototherapies. Hu B#, Li P#, Zhang Y, Shan C, Su P, Cao J*, Cheng B*, Wu W, Liu W, Tang Y*. (co-corresponding author) Inorganic Chemistry Frontiers, 2019, 6: 820-828. DOI: 10.1039/c9qi00002j. IF:5.1

3. Surface Ligand Coordination Induced Self-assembly of Nanohybrid for Efficient Photodynamic Therapy and Imaging. Su P, Zhu Z, Fan Q, Cao J*, Wang Y, Yang X, Cheng B*, Liu W, Tang Y*. (co-corresponding author) Inorganic Chemistry Frontiers, 2018, 5:2620-2629. DOI: 10.1039/C8QI00777B. IF:5.1

4. A biomolecule-based fluorescence chemosensor for sequential detection of Ag+ and H2S in 100% aqueous solution and living cells. Su P#, Zhu Z, Wang J, Cheng B*, Wu W, Iqbal K, Tang Y*. (co-corresponding author) Sensors & Actuators: B. Chemical, 2018, 273: 93-100. DOI: 10.1016/j.snb.2018.06.037. IF:5.4

5. Functionalized Eu(III)-Based Nanoscale Metal-Organic Framework To Achieve Near-IR-Triggered and -Targeted Two-Photon Absorption Photodynamic Therapy.Jia J, Zhang Y, Zheng M, Shan C, Yan H, Wu W, Gao X, Cheng B*, Liu W, Tang Y*. (co-corresponding author) Inorganic Chemistry. 2018 Jan; 57 (1):300- 310. DOI:10.1021/acs.inorgchem.7b02475. IF:4.8

6. Structural and functional diversity of mammalian CBX proteins (in Chinese).Guan S, Wang J, Xie Y, Cheng B. (corresponding author) (Invited article) Sci Sin Vitae. 2017 Aug; 47 (8):847-862. DOI:10.1360/N052017-00012

7. KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. Cheng B*, Ren X*, and Kerppola TK.  (co-first author) Molecular and Cellular Biology. 2014 Jun; 34(11):2075- 91.  DOI:10.1128/MCB.01729-13.  IF:3.8

8. Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins. Ma R, Zhang Y, Sun T, Cheng B. (corresponding author) (Invited article) Journal of Zhejiang University-Science B. 2014 April; 15(5):412-28. DOI: 10.1631/ jzus.B1400077. IF:1.8  

9. Functional association of Gdown1 with RNA polymerase II poised on human genes. Cheng B*, Li T*, Rahl PB, Adamson TE, Loudas NB, Guo J, Varzavand K, Cooper JJ, Hu X, Gnatt A, Young RA, Price DH. Molecular Cell. 2012 Jan;45(1): 38- 50. (co-first author) (cover story with preview article) DOI:10.1016/j.molcel.2011. 10.022. IF:15.3

10. Isolation and functional analysis of RNA polymerase II elongation complexes. Cheng B, Price DH.(first author) (invited article) Methods. 2009 Aug;48(4):346- 52. DOI:10.1016/j.ymeth.2009.02.026. IF:4.0

11. Analysis of factor interactions with RNA polymerase II elongation complexes using a new electrophoretic mobility shift assay. Cheng B, Price DH. (first author) Nucleic Acids Research. 2008 Nov;36(20):e135. DOI:10.1093/nar/gkn630. IF:11.6

12. Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. Cheng B, Price DH. (first author) Journal of Biological Chemistry. 2007 Jul;282(30):21901-12. DOI: 10.1074 /jbc.M702936200. IF:4.0

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