联系方式

  • 职  称: 青年研究员
  • 所在部门: 动物学与发育生物学研究所
  •  办公室: 逸夫生物楼304
  • 联系电话:
  • 传真号码:
  • 电子邮件: chaoxj@
  • 个人主页:
学习经历

2009.09-2015.12 中科院生态环境研究中心,环境科学专业,理学博士,导师:朱本占研究员

2004.09-2009.07 南昌大学(公共卫生学院),预防医学专业,本科

工作经历

 

2019.04-至今,兰州大学,生命科学学院,青年研究员

 

2016.09-2019.03 中山大学,化学学院,副研究员

社会工作
研究方向

 

包括复合毒性研究;金属配合物的潜在抗癌效应及光动力学治疗方面的研究;探针设计及细胞荧光成像。

 

项目成果

 广东省自然科学基金:小分子促进细胞膜非通透性金属配合物细胞核的摄取及抗肿瘤机理研究,2018A030310242,主持

 国家自然科学基金重点项目:基于溶液结构的四链体核酸功能的铂配合物调控,参与

 国家自然科学基金重点项目:有机农药与含铜、锌无机农药的协同毒性作用机理研究,参与

 国家自然科学基金创新群体项目:持久性有毒污染物的环境过程与毒理效应,参与

 广东省自然科学基金:G-四链体靶向的无机-有机杂化多核铂(II)配合物选择性诱导癌细胞端粒功能障碍的研究,参与
荣誉、获奖
教学及指导研究生情况
发表论文及专著

1. Chao XJ, Tang M, Huang R, Huang C-H,Shao J, Yan ZY and Zhu BZ*.(2019)Targeted live-cell nuclear delivery of the DNA ‘light-switching’ Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes.Nucleic Acids Research, DOI:10.1093/nar/gkz152.

2. Chao XJ#, Pan ZY#, Sun LL, Tang M, Wang KN, Mao Z -W*. (2019)A pH-independent near-infrared fluorescent tracker for wash-free lysosome-specific imaging with long time under physiological and pathhological processes.Sensors and actuators B-Chemical,285,156-163.

3. Chao XJ#, Wang KN#, Sun LL, Cao Q, Ke ZF, Cao DX, Mao Z -W*. (2018)Cationic organochalcogen with monomer/excimer emission for dual-color live cell imaging and cell damage diagnosis. ACS Applied Materials and Interfaces,10, 13264-13273.

4. Wang KN#, Chao XJ#, Liu B, Zhou DJ, He L, Zheng XH, Cao Q, Tan CP, Zhang C, Mao Z -W*.(2018)Red fluorescent probes for real-time imaging of the cell cycle by dynamic monitoring of the nucleolus and chromosome. Chemical Communication,54,2635-2638. 

5. Zhu BZ*, Chao XJ, Huang C-H and Li Y. (2016)Delivering the cell-impermeable DNA ‘Light-switching’ Ru(II) complexes into the nucleus of living cells via ion-pairing. Chemical Science, 7, 4016-4023. (导师一作)

6. Zhu BZ*, Chao XJ.(2016)Redirecting Ru(II)-complex into live-cell nucleus for enantioselective DNA-imaging and photosensitizing via simple Yin-Yang ion-pairing. Free Radical Biology and Medicine,100, S33-S34. (摘要论文)

7. Wang KN, Sun PZ, Chao XJ, Cao DX*, Mao Z -W*, Zhiqiang Liu*. (2018)A coumarin Schiff's base two-photon fluorescent probe for hypochlorite in living cells and zebrafish. RSC advances,8, 6904-6909.

8. Sheng ZG, Shen C, Fan RM, Chao XJ, Liu YX, Zhu BZ*. (2018)The Critical Role of X Chromosome-linked Inhibitor of Apoptosis (XIAP) in Differential Synergism Induced by Pentachlorophenol and Copper-1,10-phenanthroline Complex in Normal and Cancer Liver Cells. Toxicol. Sci.,0, 1-10.

9. Sheng ZG, Li Y, Fan RM, Chao XJ, Zhu BZ*. (2013)Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex. Toxicol. Appl. Pharmacol.,266, 335-344.

10. Sheng ZG, Tang Y, Liu YX, Yuan Y, Zhao BQ, Chao XJ, Zhu BZ*. (2012)Low concentrations of bisphenol A suppress thyroid hormone receptor transcription through a nongenomic mechanism. Toxicol. Appl. Pharmacol.,259, 133-142.

11. 朱本占*,肖璇,巢细娟,唐苗,黄蓉, 邵杰。(2018)DNA分子“光开关”含钌多吡啶络合物细胞摄取、胞内分布及毒性机理研究。Progress in Chemistry,30, 1975-1991.

12. 专利:朱本占,巢细娟,一种促进Ru(II)金属络合物细胞核摄取的方法。 专利号:201510531733.2

 

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