兰州大学生命科学学院 教授 董守良 (Shouliang Dong)

学习经历

1991.9-1995.6,兰州大学生物系,本科;
1995.9-1998.6,兰州大学生命科学学院,硕士;
1998.9-2001.6,兰州大学生命科学学院,博士;

工作经历

2001.7-2004.5,兰州大学生命科学学院,讲师;
其中2003.11-2004.11,德国马克斯-普朗克生物化学研究所,博士后;
2004.5-2012.4,兰州大学生命科学学院,副教授;
其中2007.3-2008.9,德国马克斯-普朗克生物化学研究所,客座学者;
2012.5-今,兰州大学生命科学学院,教授;

教学及指导研究生情况

本科生教学:
系统讲授《动物生理学》、《动物生理学实验》、《计算机辅助药物设计》课程,参与《兰大导读(生命科学史)》课程。

研究生教学:
系统讲授《计算机辅助药物设计》课程,负责相关专业《博士生前沿讲座》。

指导研究生情况:
在校人员
                  姓名     Email                           职务        籍贯     

2017级      张   静  zhangj14[a]lzu.edu.cn  博士生    江苏
                王    豪  wangh2017[a]lzu.edu.cn 硕士生    河南
                马    婵  chma17[a]lzu.edu.cn  硕士生    甘肃

2016级     贺春波  hechb16[a]lzu.edu.cn  博士生    河北
                兰煜衡   lanyh16[a]lzu.edu.cn      硕士生    甘肃  
                王倩倩   wangqq16[a]lzu.edu.cn   硕士生   甘肃

2015级     杨丽霞  yanglx15[a]lzu.edu.cn  硕士生    贵州
                 李海兰  lihl2015[a]lzu.edu.cn  硕士生    甘肃
2014级     刘正锟  liuzhk14[a]lzu.edu.cn  博士生     甘肃

发表论文及专著

2017
73. Xiangdong Cai, Zhao Liu, Sha Zhao, Chen Song, Shouliang Dong * and Jianxi Xiao*. A single stranded fluorescent peptide probe for targeting collagen in connective tissues. ChemComm. 2017.53: 11905-11908 DOI: 10.1039/c7cc06056d
72. 董守良,玄其存,曹硕,常民. 一种布舍瑞林的固液合成方法. 国家发明专利, 已授权(授权日:2017/09/27): ZL201410741975.X.
71. Xu Li,Zhengkun Liu and Shouliang Dong*. Bicyclo[6.1.0]nonyne and tetrazine amino acids for Diels-Alder Reactions. RSC Advances. 2017, 7, 44470-44473. DOI: 10.19/c7ra08136g
70. Chunbo He, Hailan Li, Jing Zhang, Yanping Kang, Fang Jia, Shouliang Dong*, Lanxia Zhou*. Supraspinal Inhibitory Effects of Chimeric Peptide MCRT on Gastrointestinal Motility in Mice. Journal of Pharmacy and Pharmacology. 2017, 69, 1244-1251. doi: 10.1111/jphp.12761.
69. 董守良, 曹硕, 李兆亮, 葛鑫. 一种地加瑞克的固相合成方法. 国家发明专利, 已授权(授权日期:2017/02/21): ZL201410211655.3.

2016
68. Jing Zhang, Chunbo He, Xiong Pi, Yan Wang, Lanxia Zhou*, Shouliang Dong*. MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B. European Journal of Pharmacology. 2016, 792, 33-37. DOI: 10.1016/j.ejphar.2016.10.028
67. S. Cao, Q. Jin, L.Geng, L. Mu and S. Dong*, A “turn-on” fluorescent probe for detection of Cu2+ in living cells based on signaling mechanism of N=N isomerization. New J. Chem., 2016, 40, 6264 - 6269. DOI: 10.1039/C5NJ03649F
66. Chunbo He, Junbin Gong, Lixia Yang, Hongwei Zhang, Shouliang Dong*,Lanxia Zhou*. The pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice. Canadian Journal of Physiology and Pharmacology. 2016, 94: 955–960. DOI: 10.1139/cjpp-2015-0554.
 

2015
65. Zhongqiu Ni, Lanxia Zhou, Xu Li, Jing Zhang, Shouliang Dong*. Tetrazine-Containing Amino Acid for Peptide Modification and Live Cell Labeling. PLOS One (2015), 10(11): e0141918. Doi: 10.1371/journal.pone.0141918.
64. Lanxia Zhou⁎, Qing Yang, Chunbo He, Chunnan Wei, Yinliang Yang, Shouliang Dong⁎⁎. Interaction of endokinin A/B and (Mpa6)-γ2-MSH-6–12 in pain regulation in mice, Neuropeptides (2015),53, 79-84. DOI: 10.1016/j.npep.2015.06.007.
63. 李兆亮,葛鑫,董守良. 一种ivDde-OH的纯化方法. 国家发明专利, 申请中: 201510012031.3.

2014
62. 董守良,刘连喜,刘正锟,常民. 一种缩酯环肽类组蛋白去乙酰化酶抑制剂的中间体及其制备方法. 国家发明专利, 申请中: 201410805068.7.

2013
61.周兰霞,董守良,倪中秋. 一种化合物L-4-四嗪-苯丙氨酸及其制备方法和应用, 国家发明专利, 已授权: ZL201210080698.3
60. Jianbing Jiang, Longfei Yang, Qiaoying Jin, Wude Ma, Luis Moroder, Shouliang Dong*. Site-Directed Spin Labeling of a Collagen Mimetic Peptide. Chem. Eur. J. 2013, 19, 17679-17682. DOI: 10.1002/chem.201303290.
59. 董守良,刘正锟,李晓莉,抗肿瘤药物罗米迪司肽的关键中间体的合成方法,国家发明专利,已授权。专利号:ZL201110123735X.
58. 董守良,李梅兴. 一种齐考诺肽的固相合成方法,国家发明专利,已授权。专利号:ZL201110139661.9.
57. Meixing Li, Lanxia Zhou, Guoning Ma, Shuo Cao, Shouliang Dong*. The cardiovascular effects of a chimeric opioid peptide based on morphiceptin and PFRTic-NH2. Peptides, 2013,39(1):89-94. Doi: 10.1016/j.peptides.2012.10.014.

2012
56. Meixing Li, Lanxia Zhou, Guoning Ma, Shouliang Dong*. Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide. Regulatory Peptides. 2012, 179, 23-28. DOI: 10.1016/j.regpep.2012.08.008.
55. Lanxia Zhou, Qiaoying Jin, Yinliang Yang, Zhengkun Liu, Xiaoli Li, Shouliang Dong*, Li Zhao**. Effects of Endokinin A/B and Endokinin C/D on the antinociception of properties of hemopressin in mice. Peptides.2012,38: 70-80. DOI: 10.1016/j.peptides.2012.08.006
54. 陈强, 董守良, 常民. 兰州大学生物科学专业动物生理学精品课程的建设. 中国生理学会第十届全国生理学教学研讨会论文摘要汇编, 2012. 中国生理学会第十届全国生理学教学研讨会. 2012-05-11, 中国江西南昌.
2011 
53. Qiaoying Jin, Li Lu, Yinliang Yang, Shouliang Dong*. Effects of Endokinin A/B, Endokinin C/D, and Endomorphin-1 on the regulation of mean arterial blood pressure in rats. Peptides. 32 (2011) 2428–2435. Doi: 10.1016/j.peptides.2011.10.017; 
52. Bo Zhang, Junbin Gong, Yinliang Yang, Shouliang Dong*. Synthesis and diuretic activities of pseudoproline-containing analogues of the insect kinin core pentapeptide. J. Pept. Sci. 2011; 17: 601–603. DOI: 10.1002/psc.1396. 
51. Wenwei Zhang, Yuling Zeng, Shasha Wang, Qing Yang, Shouliang Dong*. Conformation analysis of a bradykinin B2 receptor antagonist, a proline rich undecapeptide. Acta Biophysica Sinica. 27(11): 937-940. DOI: 10.3724/SP.J.1260.2011.00937. 
50. Long-Fei Yang, Yang Xiao, Yun Huang, Guo-Ning Ma, Zhi-Yuan Cong and Shou-Liang Dong*. In vitro characterization for the effects of insect kinins on mouse distal colonic motility. In "Peptides: Chemistry, Biology and Pharmaceutical Sciences", Ed. by Rui Wang and Kai-Rong Wang, Proceedings of the 11th Chinese International Peptide Symposium, July 5-8, 2010, Lanzhou, China. July, 2010, 199-203
49. Tobias E. Schrader,Thorben Cordes,Wolfgang J. Schreier,Florian O. Koller, Shou-Liang Dong, Luis Moroder, Wolfgang Zinth. Folding and Unfolding of Light-Triggered β-Hairpin Model Peptides. J. Phys. Chem. B. 2011, 115, 5219–5226. DOI: 10.1021/jp107683d.
48. Jing Wang, Li Wang, Meixing Li, Qiaoying Jin, Shouliang Dong*. Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides. Peptides. 2011, 32; 1055–1059. doi:10.1016/j.peptides.2011.01.032.
2010
47. ChunnanWei, Wenmin Huang, Xiaoting Xing and Shouliang Dong*. Dual effects of [Tyr6]-γ2-MSH(6–12) on pain perception and in vivo hyperalgesic activity of its analogues. J. Pept. Sci. 2010,16, 451-455. DOI: 10.1002/psc.1255 (SCI) 
46. Sha-Sha Wang, Yu-Ling Zeng, Wen-Wei Zhang, Shou-Liang Dong*. A snake venom peptidewith the contrary effect on rat stomachfundus and guinea pig ileum. Pharmazie.,2010,65: 383–385. doi: 10.1691/ph.2010.9683 (SCI)
45. Yinliang Yang, Zhongqiu Ni, Shouliang Dong*, Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice. Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice. Peptides, 2010,31(4): 689-695. doi:10.1016/j.peptides.2009.12.022
44. Zhiyuan Cong, Yun Huang, Longfei Yang, Dan Ye, Shouliang Dong*, Solution structure of a photo-switchable insect kinin thioxo-analog. Protein & Peptide Letters. 2010,17(3): 343-346. 
43. 魁红,罗会颖,董守良,姚斌. 一种来源于Bispora betufina的酸性木聚糖酶基因克隆及其酶学性质研究. 中国农业科技导报,2010,12(5):109—1 15.
42. 张 波, 丛志远, 杨银亮, 杨龙飞, 董守良*. 昆虫激肽的生理功能及机制. 生命的化学.,2010,30(1): 42-45.
41. Zhiyuan Cong, Longfei Yang, Ling Jiang, Dan Ye, Shouliang Dong*. Comparison of two thioxopeptide bond photoswitches in insect kinin. Chinese Chemical Letters. 2010,21(4): 476-479. doi:10.1016/j.cclet.2009.12.033
40. Hong Kui, Huiying Luo, Pengjun Shi, Yingguo Bai, Tiezheng Yuan, Yaru Wang, Peilong Yang, Shouliang Dong, Bin Yao. Gene Cloning, Expression, and Characterization of a Thermostable Xylanase from Nesterenkonia xinjiangensis CCTCC AA001025. Appl Biochem Biotechnol. 2010,162(4):953-65. DOI: 10.1007/s12010-009-8815-5.
39. Yinliang Yang, Shouliang Dong*. Effects of Endokinin A/B and Endokinin C/D on the modulation of pain in mice. Peptides. 2010,31(1), 94-100. doi:10.1016/j.peptides.2009.10.013.
38. Guohua Lv, Shouliang Dong*. Solution Structural Investigation and Conformation-Activity Relationship of BAM8-22 by NMR and Molecular Dynamics Simulations. Bioorganic & Medicinal Chemistry Letters. 2010,20(3), 1260-1262. doi: 10.1016/j.bmcl.2009.11.110.
2009
37. Shouliang Dong, Luis Moroder, Nediljko Budisa. Protein Iodination by Click Chemistry. ChemBioChem, 2009,10, 1149-1151. DOI: 10.1002/cbic.200800816.
36. 马国宁, 董守良*. 阿片肽样嵌合肽. 生命的化学. 2009,29(3), 414-417.
2008
35. Huang, Y., Cong, Z., Yang, L., and Dong, S*. A photoswitchable thioxopeptide bond facilitates the conformation-activity correlation study of insect kinin, J Pept Sci 2008,14, 1062-1068.
34. Dong, S., Merkel, L., Moroder, L., and Budisa, N. Convenient syntheses of homopropargylglycine, J Pept Sci 2008, 14, 1148-1150.
33. Li Zhao, Lanxia Zhou, Baohong Zhang, Xiang Yan, Juan Li, Yali Peng, Min Chang, Shouliang Dong, Rui Wang, Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell, Pharmazie, 2008,63: 676-685.
32. Dong, S.L., Merkel, L., Musiol, H.J., Budisa, N. and Moroder, L. (2008). Advances in the stereoselective synthesis of homopropargylglycine. J. Peptide Sci. 2008,14 (8), 49-49.
31. 金莲,刘鑫,王锐,董守良*,神经介素B 受体与拮抗剂、激动剂的分子模拟研究,化学学报,2008,2271-2278.
30. 杨丹,董守良*,人体激肽释放酶2与前列腺癌,生命的化学,2008,731-736.
2007
29. Zinth, W., Schrader, T. E., Schreier, W. J., Koller, F. O., Cordes, T., Babitzki, G., Denschlag, R., Tavan, P., Loweneck, M., Dong, S. L., Moroder, L., and Renner, C. Ultrafast unzipping of a beta-hairpin peptide, Ultrafast Phenomena Xv 2007,88, 498-500.
28. Yu, Y., Shao, X., Cui, Y., Liu, H., Wang, C., Fan, Y., Liu, J., Dong, S., and Wang, R. Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus, Chemmedchem 2007,2, 309-317.
27. Schrader, T. E., Schreier, W. J., Cordes, T., Koller, F. O., Babitzki, G., Denschlag, R., Renner, C., Loweneckt, M., Dong, S. L., Moroder, L., Tavan, P., and Zinth, W. Light-triggered beta-hairpin folding and unfolding, Proceedings of the National Academy of Sciences of the United States of America 2007,104, 15729-15734.
26. Dong, S. L., Cadamuro, S. A., Fiorino, F., Bertsch, U., Moroder, L., and Renner, C. Copper binding and conformation of the N-terminal octarepeats of the prion protein in the presence of DPC micelles as membrane mimetic, Biopolymers 2007,88, 840-847.
25. 周兰霞,金莲,赵丽,孟雪琴,董守良*,ArcGIS910在苯丙酮尿症空间分析中的应用,中国卫生统计,2007,24,604-606.
2006
24. Peng, Y. L., Chang, M., Dong, S. L., Li, W., Han, R. W., Fu, G. X., Chen, Q., and Wang, R. Novel potent agonist (pF)Phe(4),Aib(7) Aib(11),Arg(14),Lys(15) N/OFQ-NH2 and antagonist Nphe(1),(pF)Phe(4),Aib(7),Aib(11),Arg(14),Lys(15) N/OFQ-NH2 Of nociceptin/orphanin FQ receptor, Regulatory Peptides 2006,134, 75-81.
23. Loeweneck, M., Dong, S.-L., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photo-controlled beta-hairpin, Understanding Biology Using Peptides, 2006,36-37. (ISTP)
22. Dong, S. L., Loweneck, M., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photocontrolled beta-hairpin peptide, Chemistry-a European Journal 2006,12, 1114-1120.
2005
21. Musiol, H.-J., Dong, S., Kaiser, M., Bausinger, R., Zumbusch, A., and Moroder, L. Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins, Peptides 2004, Proceedings:BRIDGES BETWEEN DISCIPLINES, 595-596. (ISTP)
20. Musiol, H. J., Dong, S. L., Kaiser, M., Bausinger, R., Zurnbusch, A., Bertsch, U., and Moroder, L. Toward semisynthetic lipoproteins by convergent strategies based on click and Ligation chemistry, Chembiochem 2005,6, 625-628. (SCI,生物二区)
19. Musiol, H. J., Dong, S. L., Kaiser, M., Bausinger, R., Zumbusch, A., and Moroder, L. Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins, Peptides 2004, Proceedings, 595-596. (ISTP)
18. Loeweneck, M., Dong, S. L., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photo-controlled beta-hairpin, Biopolymers 2005,80, 547. (SCI, abstract)
17. Chang, M., Peng, Y. L., Dong, S. L., Han, R. W., Li, W., Yang, D. J., Chen, Q., and Wang, R. Structure-activity studies on different modifications of nociceptin/orphanin FQ: Identification of highly potent agonists and antagonists of its receptor, Regulatory Peptides 2005,130, 116-122. (SCI)
16. 刘鑫,董守良*. 胸腺5肽同其受体结合的分子模型. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p86
15. 彭雅丽,常民,李威,韩仁文,付国兴,董守良,王锐. (2005) 孤啡肽N末端修饰类似物的构效关系研究. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p94
14. 常民,彭雅丽,韩仁文,李威,付国兴,董守良,王锐. (2005) 孤啡肽不同修饰的构效关系研究:孤啡肽受体激动剂和拮抗剂的检定. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p145
2004
13. Shouliang Dong, Tao Wang, Bangzhi Zhang, Jie Wei, and Rui Wang. Synthesis and hypotensive activity of [Tyr1]NC(1-13)NH2, an analog of nociceptin. in Peptides, Biology and Chemistry, Eds, Yu-cang Du, You-shang Zhang, James P. Tam (2004). 189-191.
2003
12. Da, C. S., Wei, J., Dong, S. L., Xin, Z. Q., Liu, D. X., Xu, Z. Q., and Wang, R. Highly catalytic enantioselective epoxidation of enones with weak base bicarbonate and hydrogen peroxide, Synthetic Communications 2003,33, 2787-2792. (SCI)
11. 李仁德,董守良,陈强. (2003) 人体及动物生理学实验指导. 兰州大学出版社.
2002
10. Xin, Z. Q., Da, C. S., Dong, S. L., Liu, D. X., Wei, J., and Wang, R. A novel method for the synthesis of (R)-2,2 '-dihydroxy-1,1 '-binaphthyl-3,3 '-dicarboxylic acid by asymmetric oxidative coupling of a chiral beta-naphthol derivative catalyzed by CuCl, Tetrahedron-Asymmetry 2002,13, 1937-1940. (SCI)
9. Zheng-Ping Jia, Shou-Liang Dong, Xiao-Wu Yang, Bang-Zhi Zhang Xiao-Li Wang and Rui Wang. (2002) Anticancer pharmacology of actinomycin D and its analogs. In Peptides, Biology and Chemistry. Eds, James P. Tam. P198-201
2000
8. Shou-liang Dong, Rui Wang, Tao Wang and Xiao-yu Hu. The synthesis and opioid activities of nociceptin and its fragments. In Peptides, Biology and Chemistry. Eds, Xiao-yu Hu, Rui Wang, James P. Tam. P95-97
7. Rui Wang, Tao Wang, Shou-Liang Dong, Qiang Chen and Xiao-Yu Hu. Hypotensive activities of nociceptin and its fragments. In Peptides, Biology and Chemistry. Eds, Xiao-yu Hu, Rui Wang, James P. Tam. P108-109
6. 陈强; 陈勇; 陈鲤翔; 杨顶建; 董守良; 王锐; 痛稳素的合成及其对血管活性的影响, 科学通报,2000,45,2620-2625 (SCI)
1999
5. 董守良,王涛,陈强,王锐. 孤啡肽及其片段的合成和构效关系. 科学通报,1999,44,1296-1300 (SCI)
4. 董守良, 王 涛, 陈 强, 王 锐. 孤啡肽及其片段的合成、痛觉调节作用和对免疫功能的影响. 药学学报,1999,34,669-672 (CSCD)
3. 董守良,王 涛,王 锐. 孤啡肽研究进展. 中国药理学通报,1999,15,300-303 (CSCD)
1998
2. 董守良,倪京满,王 勤,王 锐. 放线菌素D 及类似物对荷瘤小鼠生理生化影响. 兰州大学学报,1998,34,137-138 (CSCD)
1997
1. WANG R, NI J, HU X, MA Y, LI X, YANG D, DONG S, YANG X, and PAN X. Synthesis and DNA-binding ability of Spl protein zinc finger domain and its peptidomimetics. Science in China, Ser. C, 1997,5, 518-523

研究方向

1. 生物有机化学、分子探针及药物合成应用
    优化经典有机化学反应,使其应改用于药物合成、生物大分子的标记和改造等;设计新型分子探针用于检测信号通路;
2. 生物活性肽的改造和生理、药理学检定和多肽药物合成
    使用非天然氨基酸或者化学键代替原始氨基酸或者肽键,设计并合成新型生物活性多肽,使之具备比母体更好的活性和持久的药物时间。

项目成果

1. 国家自然科学基金青年基金;
2. 国家自然科学基金面上项目;
3. 甘肃省自然科学基金青年基金;
4. 教育部留学归国人员启动基金;
5. 企业协作科研项目多项;

荣誉、获奖

2. 甘肃省科技进步二等奖2014(3/7)
2. 甘肃省精品课程(2011)
3. 兰州大学青年教师隆基奖(2010)
4. 德国克虏伯基金会中国青年学者奖(2003)
5. 甘肃省精品课程/一等奖/甘肃省教育厅/2003/(3/3)
6. 教育部理科基地名牌课程/一等奖/教育部/2002/(2/3)
7. 内吗啡肽2类似物EM-2(Ala4-NH-Bn)的合成及其镇痛活性研究,挑战杯一等奖;2002
8. 神经肽类似物的设计合成、溶液构象和生物活性,教育部科技成果鉴定(2001, 第三完成人)
9. 甘肃省科技进步三等奖2001(2/10)
10. 甘肃省科技进步二等奖1999(7/10);

社会工作

1. 中国化学会会员;
2. 中国生物化学与分子生物学学会会员;
3. 中国生理学学会会员
4. 美国多肽学会会员
5. 甘肃省生理学会会员

 

其它信息

已毕业学生:
届       姓  名           去向 (截至离校时)

2017    贾  芳          南京圣和药业
             康艳萍         四川科伦药业股份有限公司
             张   静         兰州大学博士生

2016    耿  琳          北京义翘神州生物技术有限公司
             贺春波         兰州大学博士生

2015    李  续          鲁抗辰欣药业股份有限公司
             曹  硕          北京双鹤药业研究院
2014    马吾得          深圳市康哲药业有限公司
2013    刘正锟          甘肃中医学院
             李晓莉         西安唐都医院
              杨  青          武威市
2012     李梅兴         西安市中心医院
              金侨英       兰州大学第二医院
              宫俊斌       宝鸡市中心血站
              姜   玲      北京百世登生物医学科技公司
              倪中秋       江苏施美康药业有限公司
2011     江建冰         荷兰莱顿大学博士生
2010     王  晶          甘肃省农科院
             魁  红          兰州大学生命科学学院
             杨龙飞         西安唐都医院
             张紊玮         甘肃农业大学
2009     王  黎          兰大生命科学学院博士生
             王莎莎         北京大学 
             魏春楠         甘肃农业大学
             杨银亮         德国莱比锡大学博士生
             张   波          北京元森制药有限公司
             吕国华         德国马普所博士生
             马国宁         兰州中心血站
             丛志远         西安军队某所
2008     达文平         甘肃省疾病预防控制中心
            黄   云          德国马普所博士生
            金   莲          中科院北京计算所
            刘   鑫          兰大生命科学学院博士生
            肖   杨          北京某军区
            杨   丹          成都地奥集团
            曾玉玲         北京嘉林药业股份有限公司

【更新日期: 2017-11-20】 【点击: ...】 【登录管理