兰州大学生命科学学院 教授、博导 苟小平 (Dr. Xiaoping Gou)

学习经历

1998.09-2001.07:四川大学生命科学学院植物学专业,理学博士
1995.09-1998.07:四川大学生命科学学院植物学专业,理学硕士

1991.09-1995.07:四川大学生物系植物学专业,理学学士

1998.09-2001.07:  Ph.D., Botany, College of Life Sciences, Sichuan University
1995.09-1998.07:  M.S., Botany, College of Life Sciences, Sichuan University
1991.09-1995.07:  B.S., Botany, Department of Biology, Sichuan University

工作经历

2009.10-目前:      兰州大学萃英特聘教授,博士生导师,兰州大学生命科学学院
2001.10-2009.09:博士后,The University of Oklahoma,USA

2009.10-Present:      Professor of plant biology, School of Life Sciences, Lanzhou University, China
2001.10-2009.9:       Postdoctoral research associate, Department of Microbiology and Plant Biology, University of Oklahoma, USA

教学及指导研究生情况

1、研究生(Master and Ph.D. Programs):

欢迎报考博士、硕士研究生。

博士研究生,招生专业:植物学(071001);研究方向:植物分子遗传学、植物分子发育生物学、植物生殖生物学

硕士研究生,招生专业:植物学(071001);研究方向:植物分子生物学、植物分子发育生物学、植物细胞信号转导

目前指导博士研究生10人,硕士研究生7人。

Major for master students: Plant Biology (Plant Molecular Biology, Plant Developmental Biology, Plant Cell Signaling)

Major for Ph.D. students: Plant Biology (Plant Molecular Genetics, Plant Developmental Biology, Plant Reproductive Biology)

2、博士后(Postdoctoral Associate):

欢迎新近毕业博士合作开展博士后研究工作,兰州大学提供师资博士后以及青年研究员工作岗位。

3、教学(Teaching):

植物生殖与发育生物学(秋季,本科生)/Plant Reproductive & Developmental Biology (Fall, Undergraduate)

植物生殖生物学(秋季,研究生)/Plant Reproductive Biology (Fall, Graduate)

分子克隆与基因工程(秋季,研究生)/Molecular Cloning & Genetic Engineering (Fall, Graduate)

本科生科研训练(本科生)/Independent Study Courses in Plant Biology (Spring/Fall, Undergraduate)

发表论文及专著

# First author; * Corresponding author.

Hu C, Zhu Y, Cui Y, Cheng K, Liang W, Wei Z, Zhu M, Yin H, Zeng L, Xiao Y, Lv M, Yi J, Hou S, He K, Li J, Gou X*. (2018). A group of receptor kinases are essential for CLAVATA signaling to maintain stem cell homeostasis. Nature Plants, 4: 205-211.

Russell SD, Jones DS, Anderson S, Wang X, Sundaresan V, Gou X. (2017) Isolation of rice sperm cells for transcriptional profiling. Methods in Molecular Biology, 1669: 211-219.

Cheng X#, Gou X#, Yin H, Mysore KS, Li J, Wen J. (2017). Functional characterisation of brassinosteroid receptor MtBRI1 in Medicago truncatula. Scientific Reports, 7: 9327.

Wei Z, Yuan T, Tarkowská D, Kim J, Nam HG, Novák O, He K, Gou X, and Li J. (2017). Brassinosteroid biosynthesis is modulated via a transcription factor cascade of COG1, PIF4 and PIF5. Plant Physiology, 174: 1260-1273.

Ou Y, Lu X, Zi Q, Xun Q, Zhang J, Wu Y, Shi H, Wei Z, Zhao B, Zhang X, He K, Gou X, Li C and Li J. (2016). RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana. Cell Research, 26: 686-698.

Chen L, Guan L, Qian P, Xu F, Wu Z, Wu Y, He K, Gou X, Li J, Hou S. (2016). NRPB3, the third largest subunit of RNA polymerase II, is essential for correct stomatal patterning and terminal differentiation in Arabidopsis. Development, 143: 1600-1611.

Zhang J, Yuan T, Duan X, Wei X, Li J, Russell SD*, Gou X*. (2016). Cis-regulatory elements determine germline specificity and expression level of an isopentenyltransferase gene in sperm cells of Arabidopsis. Plant Physiology, 170: 1524-1534.

Yue J, Qin Q, Meng S, Jin H, Gou X, Li J, Hou S. (2016). TOPP4 regulates the stability of phytochrome interacting factor 5 during photomorphogenesis in Arabidopsis. Plant Physiology, 170: 1381-1397.

Du J, Gao Y, Zhan Y, Zhang S, Wu Y, Xiao Y, Zou Bo, He K, Gou X, Li G, Lin H, Li J. (2016). Nucleocytoplasmic trafficking is essential for BAK1 and BKK1-mediated cell-death control. Plant Journal, 85: 520-531.

Wu Y, Xun Q, Guo Y, Zhang J, Cheng K, Shi T, He K, Hou S, Gou X, Li J. (2016) Genome-wide expression pattern analyses of the Arabidopsis leucine-rich repeat receptor-like kinases. Molelular Plant, 9: 289-300.

Shi T, Dimitrov I, Zhang Y, Tax FE, Yi J, Gou X, Li J. (2015). Accelerated rates of protein evolution in barley grain and pistil biased genes might be legacy of domestication. Plant Molecular Biology, 89: 253-261. 

Anderson S, Johnson C, Jones D, Conrad L, Gou X, Russell SD, Sundaresan V. (2013). Transcriptomes of isolated rice gametes characterized by deep sequencing: Evidence for distinct sex-dependent chromatin and epigenetic states before fertilization. Plant Journal, 76: 729-741.

Russell SD, Gou X, Wong CE, Wang XK, Yuan T, Wei XP, Bhalla PL, Singh MB. (2012). Genomic profiling of rice sperm cell transcripts reveals conserved and distinct elements in the flowering plant male germ lineage. New Phytologist, 195: 560-573.

Du J, Yin H, Zhang S, Wei Z, Zhao B, Zhang J, Gou X, Lin H, Li J. (2012). Somatice embryogenesis receptor kinases control root development mainly via brassinosteroid-independent actions in Arabidopsis thaliana. Journal of Integrative Plant Biology, 54: 388-399.

Gou X, Li J. (2012). Activation tagging. Methods in Molecular Biology, 876: 117-133.

Gou X#, Yin H#, He K#, Du J, Yi J, Xu S, Lin H, Clouse SD, Li J. (2012). Genetic evidence for an indispensable role of somatic embryogenesis receptor kinases in brassinosteroid signaling. PLoS Genetics, 8: e1002452.

Ge L, Gou X, Yuan T, Strout GW, Nakashima J, Blancaflor EB, Tian HQ, Russell SD. (2010). Migration of sperm cells during pollen tube elongation in Arabidopsis thaliana: behavior during transport, maturation and upon dissociation of male germ unit associations. Planta, 233:325-332.

Guo Z, Fujioka S, Blancaflor EB, Miao S, Gou X, Li J. (2010). TCP1 controls brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana. Plant Cell 22, 1161-1173.

Russell SD, Gou X, Wei X, Yuan T. (2010). Male gamete biology in flowering plants. Biochemical Society Transactions 38, 598-603.

Yang H, Gou X, He K, Xi D, Du J, Lin H, Li J. (2010). BAK1 and BKK1 in Arabidopsis thaliana confer reduced susceptibility to turnip crinkle virus. European Journal of Plant Pathology 127, 149-156.

Gou X, He K, Yang H, Yuan T, Clouse SD, Li J. (2010). Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics 11, 19.

Gou X, Yuan T, Wei X, Russell SD. (2009). Gene expression in the dimorphic sperm cells of Plumbago zeylanica: Transcript profiling, diversity, and relationship to cell type. Plant Journal 60, 33-47.

He K, Gou X, Yuan T, Lin H, Asami T, Yoshida S, Russell SD, Li J. (2007). BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways. Current Biology 17, 1109-1115.

Yuan T, Fujioka S, Takatsuto S, Matsumoto S, Gou X, He K, Russell SD, Li J. (2007). BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana. Plant Journal 51, 220-233.

Wei X, Gou X, Yuan T, Russell SD. (2006). A highly efficient in vitro plant regeneration system and Agrobacterium-mediated transformation in Plumbago zeylanica. Plant Cell Rep 25, 513-521.

研究方向

(1)受体激酶介导的细胞信号转导。受体激酶(RLKs)分布在细胞表面,从胞外环境获取信号并传递到细胞内启动下游的基因表达和调控,从而让植物体对各种信号作出正确的反应。在拟南芥中有600个以上的受体激酶,到目前为止只对其中很少一部分基因的功能有所了解。我们目前正通过反向遗传学的方法来解析这些受体激酶的生物学功能,尤其是那些可能参与调控拟南芥和玉米生殖发育过程的受体激酶的功能。

Functional Analysis of Receptor Kinases

There are more than 600 receptor-like kinases (RLKs) in Arabidopsis that locate on the surface of cells to perceive and transduce chemical signals into cells, regulating downstream gene expression and responding to a variety of biotic or abiotic stimuli. So far, biological functions have been defined for only a handful of RLKs that play crucial roles in many physiological processes in plant. My research is focusing on revealing the functions of these RLKs in Arabidopsis and maize. Preliminary studies showed that gene members of a couple of RLK subfamilies regulate anther and ovary development, and zygotic embryogenesis, which is under intensive investigation.

(2)植物生殖生物学。被子植物双受精是一个复杂的过程,一个精细胞与卵细胞融合形成合子,发育成胚胎,是下一代植物的雏形;另一个精细胞与中央细胞融合形成胚乳,为胚胎发育提供营养。双受精的成败关系到植物种群的延续,同时也关系到绝大部分农作物的产量与质量。实验室目前的工作主要是研究拟南芥和玉米雌雄生殖器官与性细胞发育调控的分子机理,以及早期胚胎发育调控的信号途径。

Plant Reproductive Biology

Double fertilization is a very complex biological process of angiosperms. After transferred into embryo sac by pollen tube, one sperm cell fuses with the egg cell, forming the zygote that will develop into the embryo, and the other sperm cell fuses with the center cell to generate the endosperm that provides nutrients for embryo development. Successful double fertilization is critical for the survival and development of every species, and is also crucial for the quantity and quality of the production of many crops. Plants have complex regulatory systems to regulate the development of sexual organs to achieve successful double fertilization and embryogenesis. My current research is focusing on those genes involved in anther, ovule and embryo development in Arabidopsis and maize.

项目成果

实验室得到国家自然科学基金委员会、教育部、科技部和兰州大学的经费支持。

1、主持项目:

国家自然科学基金面上项目《拟南芥富含亮氨酸重复类受体激酶调控合子胚胎发育的分子机理》(No.31070283);《拟南芥珠被发育的信号网络与调控机理》(No.31270229);《PzIPT1在拟南芥精细胞中表达的分子机理研究》(No.31471402);《受体激酶CIKs调控拟南芥根端分生组织稳态的分子机理》(31770312)

教育部新世纪优秀人才支持计划项目《受体激酶调控花药发育的分子机理》(No. NCET-12-0249)

教育部科学技术项目《受体激酶SERKs调控拟南芥胚胎发育的信号通路》(No.113058A)

2、参加项目:

国家自然科学基金重大研究计划重点项目《一类植物特有的转录因子TCP在油菜素内酯生物合成及信号转导中的调控机理》(No.90917019)

教育部“长江学者和创新团队发展计划”创新团队项目《植物多重抗逆的分子机理》(Nos.IRT0924, IRT_13R25)

科技部重大科学研究计划课题《植物蛋白的修饰的重要过程与调控机理》(No.2011CB9154001)

荣誉、获奖

教育部新世纪优秀人才支持计划(2012)

社会工作

其它信息

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