• 职  称: 副教授
  • 所在部门: 生物物理所
  •  办公室: 天演楼403
  • 联系电话: 0931-8912563
  • 传真号码:
  • 电子邮件: heyx@
  • 个人主页: http://qb3.berkeley.edu/qb3/tang-hyx.cfm













国家自然科学基金委面上项目:植物根际促生菌Pseudomonas-fluorescems 2P24感受与影响类黄酮的分子机制研究,执行时间:2018/01-2021/12



国家自然科学基金委面上项目:2,4-DAPG及MAPG作为荧光假单胞菌信号分子的作用机制,执行时间:2020/01-2023/12 承担经费:22万






在读研究生 4人

访问学生   2人




Guo DD*, Luo LM* et al. He YX# The regulator PltZ regulates a novel antibiotic efflux pump PltIJKNOP of Pseudomonas aeruginosa ATCC 27853 in response to 
the antimicrobial 2,4-diacetylphloroglucinol. FRONT MICROBIOL. 2020 Revision submitted

Yu XQ*, Yan X*. et al. He YX# Flavonoids repress production of antifungal 2,4-DAPG but potentially facilitate root colonization of the rhizobacterium Pseudomonas fluorescens.
 Environ Microbiol. 2020 in press

Zhang SP, Wang Q, Quan SW, Yu XQ, Wang Y, Guo DD, Peng L, Feng HY#, He YX# Type II toxin-antitoxin system in bacteria: activation, function and mode of action.
Biophysical Reports. 2020 in press

Na M, Zhang S, Liu J, Ma S, Han Y, Wang Y, He YX, Chen H, Chen X. Determination of pathogenic bacteria-Bacillus anthrax spores in environmental samples by
ratiometric fluorescence and test paper based on dual-emission fluorescent silicon nanoparticles. J Hazard Mater. 2020 Mar 15;386:121956

Zhang ZY, Bai HH, Guo Z, Li HL, He YT, Duan XL, Suo ZW, Yang X, He YX, Hu XD. mGluR5/ERK signaling regulated the phosphorylation and function of glycine
receptor α1ins subunit in spinal dorsal horn of mice. PLoS Biol. 2019 Aug 21;17(8)

Han JT*, Zhang SP*, Jia WJ, Zhang Z, Wang Y, He YX#. Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus. FEBS Journal. 2019 

Wang Y*, Zhang SP*, Zhang MY, Kempher ML, Guo DD, Han JT, Tao X, Wu Y, Zhang LQ, He YX#. The antitoxin MqsA homolog in Pseudomonas fluorescens 2P24 has a rewired regulatory circuit through evolution. Environ Microbiol. 2019 Jan 24.

Zhao JH, Chen JH, Wang Y, Wang ZP, He YX#. The putative compatible solute-binding protein ProX from Mycobacterium tuberculosis H37Rv: biochemical
characterization and crystallographic data. Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):231-235.

Yan X, Yang R, Zhao RX, Han JT, Jia WJ, Li DY, Wang Y, Zhang N, Wu Y, Zhang LQ#, He YX#. The transcriptional regulator PhlH modulates 2,4-diacetylphloroglucinol biosynthesis in response to the biosynthetic intermediate and end product. Appl Environ Microbiol. 2017 Aug 18

Li L, Zhu Y, Zhou S, An X, Zhang Y, Bai Q, He YX#, Liu H#, Yao XJ#. Experimental and Theoretical Insights into the Inhibition Mechanism of Prion Fibrillation by Resveratrol and its Derivatives. ACS Chem Neurosci. 2017 Aug 17

Sun C, Yan K, Han JT, Tao L, Lv MH, Shi T, He YX, Wierzba M, Tax FE, Li J.Scanning for New BRI1 Mutations via TILLING Analysis. Plant Physiol. 2017 Jul;174(3):1881-1896.

Nan Q, Qian D, Niu Y, He YX, Tong S, Niu Z, Ma J, Yang Y, An L, Wan D, Xiang Y. Plant Actin-depolymerizing Factors Possess Opposing Biochemical Properties Arising From Key Amino Acid Changes Throughout Evolution. Plant Cell. 2017 Jan 25

Bo Xin, Geng Wu, Kunzhi Zhang, YX He, Hongzhi Tang, Chao Gao, Ping Xu and Cuiqing Ma Sequence similarity network analysis, crystallization, and X-ray crystallographic analysis of the lactate metabolism regulator LldR from Pseudomonas aeruginosa Bioresour. Bioprocess. (2016) 3: 32.

Wu D, Tao X, Chen ZP, Han JT, Jia WJ, Zhu N, Li X, Wang ZP#, He YX#The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells. J Hazard Mater. 2016 Apr 15;307:193-201 (五年IF=5.277, JCR一区)

Zhang Z, Jiang YL, Wu Y, He YX#. Crystallization and preliminary X-ray diffraction analysis of a putative carbon-carbon bond hydrolase from Mycobacterium abscessus 103. Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):239-42.(IF=0.568, JCR四区)

Mu Y, Lian FM, Teng YB, Ao J, Jiang YL, He YX, Chen Y, Zhou CZ, Chen X. The N-terminal β-sheet of peroxiredoxin 4 in the large yellow croaker Pseudosciaena crocea is involved in its biological functions. PLoS One. 2013;8(2):e57061.(五年IF=4.015, JCR三区)


He YX, Zhang NN, Li WF, Jia N, Chen BY, Zhou K, Zhang J, Chen Y, Zhou CZ. N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease. J Mol Biol. 2012 May 4;418(3-4):197-207.(五年IF=3.795, JCR二区)

Du Y*, He YX*, Zhang ZY, Yang YH, Shi WW, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ, Chen Y. Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae. J Struct Biol. 2011 Apr;174(1):252-7.(五年IF=3.407, JCR二区)

He YX, Huang L, Xue Y, Fei X, Teng YB, Rubin-Pitel SB, Zhao H, Zhou CZ. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem. 2010 Feb 12;285(7):4603-11.(五年IF= 4.863,JCR二区)

He YX, Gui L, Liu YZ, Du Y, Zhou Y, Li P, Zhou CZ. Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly. Proteins. 2009 Jul;76(1):249-54.(五年IF=2.964,JCR三区)

Zhang WJ*, He YX*, Yang Z, Yu J, Chen Y, Zhou CZ. Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae. Proteins. 2008 Dec;73(4):1058-62.(五年IF=2.964,JCR三区)


Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC, Zhou CZ. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12487-92.

Ma G, Yu J, Xiao Y, Chan D, Gao B, Hu J, He YX, Guo S, Zhou J, Zhang L, Gao L, Zhang W, Kang Y, Cheah KS, Feng G, Guo X, Wang Y, Zhou CZ, He L. Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Res. 2011 Sep;21(9):1343-57.

Kang Y, He YX, Zhao MX, Li WF. Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1173-8.

Yang JP, Ma XX, He YX, Li WF, Kang Y, Bao R, Chen Y, Zhou CZ. Crystal structure of the 30 K protein from the silkworm Bombyx mori reveals a new member of the β-trefoil superfamily. J Struct Biol. 2011 Jul;175(1):97-103.

Du Y, Shi WW, He YX, Yang YH, Zhou CZ, Chen Y. Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC. Biochem J. 2011 Jun 1;436(2):283-9.

Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen Y, Zhou CZ. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010 Dec 15;432(3):445-50.

Du Y, He YX, Gaowa S, Zhang X, Chen Y, Zhang SC, Zhou CZ. Crystal structures of the apo and GDP-bound forms of a cupin-like protein BbDUF985 from Branchiostoma belcheri tsingtauense. Proteins. 2010 Sep;78(12):2714-9.

Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, Zhou CZ. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. J Mol Biol. 2010 May 14;398(4):614-22.

Zhang NN, He YX, Li WF, Teng YB, Yu J, Chen Y, Zhou CZ. Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis. Proteins. 2010 Jun;78(8):1999-2004.

Teng YB, Jiang YL, He YX, He WW, Lian FM, Chen Y, Zhou CZ. Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103. BMC Struct Biol. 2009 Oct 24;9:67.

Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Rep. 2009 Dec;10(12):1320-6.

Teng YB, Ma XX, He YX, Jiang YL, Du J, Xiang C, Chen Y, Zhou CZ. Crystal structure of Arabidopsis translation initiation factor eIF-5A2. Proteins. 2009 Nov 15;77(3):736-40.

Wang Y, He YX, Yu J, Zhou CZ. Cloning, overproduction, purification, crystallization and preliminary X-ray diffraction analysis of yeast glutaredoxin Grx5. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):651-3.

Huang L, Sun F, Liang C, He YX, Bao R, Liu L, Zhou CZ. Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium. Proteins. 2009 May 1;75(2):524-7. doi: 10.1002/prot.22346.

Wang S, He YX, Bao R, Teng YB, Ye BP, Zhou CZ. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of hypothetical protein SCO4226 from Streptomyces coelicolor A3(2). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):847-50. 






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