兰州大学生命科学学院 漆永梅

学习经历

2005/09-2011/07,兰州大学,生命科学学院,硕博连读/博士,导师:张迎梅教授

2008/09-2010/07,美国马里兰大学帕克分校(University of Maryland, College Park),“国家建设高水平大学公派研究生项目”联合培养博士研究生

2001/09-2005/07,河南师范大学,生命科学学院,本科/学士

工作经历

2016.05-今,兰州大学,生命科学学院,副教授

2011/07-2016.04,兰州大学,生命科学学院,讲师

2008/07-2011/06,兰州大学联合培养研究生师资

 
教学及指导研究生情况

承担本科生《生物化学》和《人体解剖生理学》课程教学

发表论文及专著

代表性论文:

1. Yongmei Qi#, Qian Qiu#, Xueyan Gu, Yihong Tian, Yingmei Zhang*, ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts, Scientific Reports, 2016, 6, 24700. (co-first author)

2. Yongmei Qi, Yingmei Zhang*, Yingxia Liu, Wenya Zhang, Nonylphenol decreases viability and arrests cell cycle via reactive oxygen species in Raji cells, Experimental and Toxicologic Pathology, 2013, 65 (1-2): 69-72.

3. Yongmei Qi, Ailing Li, Dejun Huang, Yihong Tian, Yingmei Zhang*, Exogenous S-adenosyl-L-methionine could inhibit c-myc overexpression induced by As2O3 in normal human liver HL-7702 cells, Journal of Health Science, 2011, 57(2): 188-191.

4. Yongmei Qi, Norberta W Schoene, Frederick M Lartey, Wen-Hsing Cheng*, Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells, The Journal of Biological Chemistry, 2010, 285(43): 33010–33017.

5. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, Yingmei Zhang*, ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain, Neurotoxicology, 2015, 46:19-24.

6. Xue Wei, Yongmei Qi, Xiaoning Zhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun Huang, Yingmei Zhang*, Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway, Toxicology Mechanisms and Methods, 2014, 24(7):504-511.

7. Zhen An, Yongmei Qi, Dejun Huang, Xueyan Gu, Yihong Tian, Ping Li, Hui Li, Yingmei Zhang*, EGCG inhibits Cd2+-induced apoptosis through scavenging ROS rather than chelating Cd2+ in HL-7702 cells, Toxicology Mechanisms and Methods, 2014, 24(4): 259-267.

8. Xiaoning Zhang, Xiaona Zhang, Yongmei Qi, Dejun Huang*, Yingmei Zhang*,  2,4-Dichlorophenol induces ER stress-mediated apoptosis via eIF2a dephosphorylation in vitro, Environmental Toxicology, 2016, 31(2): 245-255.

9. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Jufang Wang, Dejun Huang*, Cadmium delays non-homologous end joining (NHEJ) repair viainhibition of DNA-PKcs phosphorylation and downregulation ofXRCC4 and Ligase IV, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2015, 779: 112-123.

10. Xiaoning Zhang, Xiaona Zhang, Zhidan Niu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4,6-Trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis, International Journal of Toxicology, 2014, 33(6): 532-541.

11. Xiaoning Zhang, Hui Li, Qian Qiu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4-Dichlorophenol induces global DNA hypermethylation through the increase of S-adenosylmethionine and the upregulation of DNMTs mRNA in the liver of goldfish Carassius auratus, Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 2013, 160C: 54-59.

12. Hui Li, Xiaoning Zhang, Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway, Aquatic Toxicology, 2013, 140-141: 117-122.

13. Peng Chen, Yingxia Liu, Yanqing Sun, Che Chen, Yongmei Qi, Yingmei Zhang*, AZT and emodin exhibit synergistic growth-inhibitory effects on K562/ADM cells by inducing S phase cell cycle arrest and suppressing MDR1 mRNA/p-gp protein expression, Pharmacology Biology, 2013, 51(12):1586-1591.

研究方向

1.环境污染物致线粒体自噬的分子机理研究

2.环境污染物影响线粒体动态的生物学机制

项目成果

1.主持国家自然科学基金青年项目,31300941,ROS和ATM蛋白在亚精胺致线粒体自噬过程中的调控机理研究,2014/01-2016/12

2.主持甘肃省自然科学基金项目,145RJZA120,铅对小鼠肾脏线粒体自噬的影响及机制研究,2014/01-2016/12

3.主持甘肃省自然科学基金项目,1010RJZA107,营养元素调控DNA损伤应答及其延缓衰老和预防癌症的分子机理,2010/01-2012/12

4.主持中央高校基本科研业务费自由探索面上项目,lzujbky-2014-91,铅对人胚肾细胞线粒体自噬的影响及作用机制,2014/01-2015/12

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