联系方式

  • 职  称: 副教授/硕士研究生导师
  • 所在部门: 动物学研究所
  •  办公室: 天演楼439
  • 联系电话:
  • 传真号码:
  • 电子邮件: qiym@
  • 个人主页:
学习经历

2005/09-2011/07,兰州大学,生命科学学院,硕博连读/博士,导师:张迎梅教授

2008/09-2010/07,美国马里兰大学帕克分校(University of Maryland, College Park),“国家建设高水平大学公派研究生项目”联合培养博士研究生

2001/09-2005/07,河南师范大学,生命科学学院,本科/学士

工作经历

2016.05-今,兰州大学,生命科学学院,副教授

2011/07-2016.04,兰州大学,生命科学学院,讲师

2008/07-2011/06,兰州大学联合培养研究生师资

 
社会工作
研究方向

1.环境污染物致线粒体自噬的分子机理研究

2.环境污染物影响线粒体动态的生物学机制

项目成果

1.主持国家自然科学基金青年项目,31300941,ROS和ATM蛋白在亚精胺致线粒体自噬过程中的调控机理研究,2014/01-2016/12

2.主持甘肃省自然科学基金项目,145RJZA120,铅对小鼠肾脏线粒体自噬的影响及机制研究,2014/01-2016/12

3.主持甘肃省自然科学基金项目,1010RJZA107,营养元素调控DNA损伤应答及其延缓衰老和预防癌症的分子机理,2010/01-2012/12

4.主持中央高校基本科研业务费自由探索面上项目,lzujbky-2014-91,铅对人胚肾细胞线粒体自噬的影响及作用机制,2014/01-2015/12

荣誉、获奖
教学及指导研究生情况

承担本科生《生物化学》和《生物化学实验》课程教学

发表论文及专著

代表性论文* 通讯作者

1.Sajid Naeem, Yongmei Qi*, Yihong Tian, Yingmei Zhang*. NIX compensates lost role of Parkin in Cd-induced mitophagy in HeLa cells. Toxicology Letters, 2020, In press. (SCI大类二区)

2. Chen Zhang, Dong Li, Tingting Ge, Jiangyuan Han, Yongmei Qi*, Dejun Huang*. 2,4-Dichlorophenol induces feminization of zebrafish (Danio rerio) via DNA methylation. Science of the Total Environment. 2020, 708:135084.  (SCI大类一区, TOP期刊,当年IF 5.589)

3.Cong Yuan, Chen Zhang, Yongmei Qi, Dong Li, Yan Hu, Dejun Huang*, 2.2,4-Dichlorophenol induced feminization of zebrafish by down-regulating male-related genes through DNA methylation. Ecotoxicology and Environmental Safety. 2019 Dec 6;189:110042. doi: 10.1016/j.ecoenv.2019.110042 (SCI大类二区)

4. Xueyan Gu, Yongmei Qi*,Zengxiu Feng,Lin Ma, Ke Gao,Yingmei Zhang*, Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicology Letters, 2018, 291:92-100. (SCI大类二区)

5. Yongmei Qi#, Qian Qiu#, Xueyan Gu, Yihong Tian, Yingmei Zhang*, ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts, Scientific Reports, 2016, 6, 24700. (SCI大类二区)

6. Yongmei Qi, Yingmei Zhang*, Yingxia Liu, Wenya Zhang, Nonylphenol decreases viability and arrests cell cycle via reactive oxygen species in Raji cells, Experimental and Toxicologic Pathology, 2013, 65 (1-2): 69-72.

7. Yongmei Qi, Ailing Li, Dejun Huang, Yihong Tian, Yingmei Zhang*, Exogenous S-adenosyl-L-methionine could inhibit c-myc overexpression induced by As2O3 in normal human liver HL-7702 cells, Journal of Health Science, 2011, 57(2): 188-191.

8. Yongmei Qi, Norberta W Schoene, Frederick M Lartey, Wen-Hsing Cheng*, Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells, The Journal of Biological Chemistry, 2010, 285(43): 33010–33017.(SCI大类二区)

9. Dejun Huang*, Xiaoning Zhang, Chen Zhang, Hui Li, Dong Li, Yan Hu, Feng Yang, Yongmei Qi. 2018. 2,4-Dichlorophenol induces DNA damage through ROS accumulation and GSH depletion in goldfish Carassius auratus. Environ Mol Mutagen. 59, 798-804. (SCI大类二区)

10. Tingting Ge, Jiangyuan Han, Yongmei Qi, Xueyan Gu, Lin Ma, Chen Zhang, Sajid Naeem, Dejun Huang*. 2017. The toxic effects of chlorophenols and associated mechanisms in fish. Aquatic Toxicology. 184, 78-93. (SCI大类二区,Top期刊)

11. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, Yingmei Zhang*, ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain, Neurotoxicology, 2015, 46:19-24.

12. Xue Wei, Yongmei Qi, Xiaoning Zhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun Huang, Yingmei Zhang*, Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway, Toxicology Mechanisms and Methods, 2014, 24(7):504-511.

13. Zhen An, Yongmei Qi, Dejun Huang, Xueyan Gu, Yihong Tian, Ping Li, Hui Li, Yingmei Zhang*, EGCG inhibits Cd2+-induced apoptosis through scavenging ROS rather than chelating Cd2+ in HL-7702 cells, Toxicology Mechanisms and Methods, 2014, 24(4): 259-267.

14. Xiaoning Zhang, Xiaona Zhang, Yongmei Qi, Dejun Huang*, Yingmei Zhang*,  2,4-Dichlorophenol induces ER stress-mediated apoptosis via eIF2a dephosphorylation in vitro, Environmental Toxicology, 2016, 31(2): 245-255.

15. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Jufang Wang, Dejun Huang*, Cadmium delays non-homologous end joining (NHEJ) repair viainhibition of DNA-PKcs phosphorylation and downregulation ofXRCC4 and Ligase IV, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2015, 779: 112-123. (SCI大类二区)

16. Xiaoning Zhang, Xiaona Zhang, Zhidan Niu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4,6-Trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis, International Journal of Toxicology, 2014, 33(6): 532-541.

17. Xiaoning Zhang, Hui Li, Qian Qiu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4-Dichlorophenol induces global DNA hypermethylation through the increase of S-adenosylmethionine and the upregulation of DNMTs mRNA in the liver of goldfish Carassius auratus, Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 2013, 160C: 54-59.

18. Hui Li, Xiaoning Zhang, Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang*, Yingmei Zhang*, 2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway, Aquatic Toxicology, 2013, 140-141: 117-122.(SCI大类二区)

19. Peng Chen, Yingxia Liu, Yanqing Sun, Che Chen, Yongmei Qi, Yingmei Zhang*, AZT and emodin exhibit synergistic growth-inhibitory effects on K562/ADM cells by inducing S phase cell cycle arrest and suppressing MDR1 mRNA/p-gp protein expression, Pharmacology Biology, 2013, 51(12):1586-1591.

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更新:2020-03-04 | 访问:... | 二维码 | 维护教师主页