联系方式

  • 职  称: 教授
  • 所在部门: 动物学与生物医学系
  •  办公室: 兰州大学天演楼207
  • 联系电话: 18919877920
  • 传真号码:
  • 电子邮件: zwh@
  • 个人主页:
学习经历
2011年01月-2014年12月 巴黎第十一大学,结构生物学,博士研究生
2008年09月-2010年12月 兰州大学/中科院生物物理所,生物物理学,硕士研究生
2003年09月-2008年07月 山东理工大学,生物工程,大学本科
工作经历
2018年03月-           兰州大学,生命科学学院,教授;
2015年01月-2018年3月   法国国家科学研究中心,巴黎-萨克雷大学,博士后研究员。
社会工作
研究方向

We have a keen interest in how the structural configurations and biological functions of macromolecules are altered by covalent modifications such as post-transcriptional modification of nucleic acids and post-translational modifications of proteins. An increasingly large number of chemical modifications are being characterized along with the expansion of human knowledge and development of highly resolutive techniques, providing insights into dissecting the regulation layers in modifying the structural dynamics and functions. Our lab combines molecular biology, protein biochemistry, molecular dynamics and structural biology to characterize the mechanisms and cellular functions of tRNA t6A (N6-threonylcarbamoyladenosine), an essential and complex modification 3' adjacent to anticodon in ANN-decoding tRNAs in the three domains of life. Furthermore, we are monitoring and analyzing the cellular metabolic aberrations in context of t6A abnormality. We are also developing structure-guided discovery of anti-bacterial and anti-fungal compounds using t6A systems as targets. Nonetheless, our lab is channeling partial efforts in studying the reversible phosphocholination modification of peptides and translating the basics into a removable labeling techniques of macromolecules.  

项目成果
荣誉、获奖
教学及指导研究生情况

 本科生课程: 

《生物化学与分子生物学》

兰州大学药学院

《生物化学》

兰州大学生命科学学院、兰州大学草地农业科技学院


研究生课程

Practical Introduction to Structural Study of Macromolecules》

兰州大学生命科学学院英文课程

发表论文及专著
  1. Galicia, C., Lhospice, S., Varela, P., Trapani, S., Zhang, W., Navaza, J., Herrou, J., Mignot, T. and Cherfils, J., (2019) MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus. Nature Communications. (In Press)
  2. Das, S., Malaby, A., Nawrotek, A., Zhang,W., Zeghouf, M., Maslen, S., Skehel, M., Chakravarthy, S., Irving, T., Bilsel, O., Cherfils J. and Lambright, D. (2019) Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes. Structure. (In Press)
  3. Missoury, S., Plancqueel, S., Gallay, I., Zhang, W., Liger, D., Durand, D., Dammak, R., Collinet, B. and van Tilbeurgh, H. (2018) The crystal structure of the bacterial TsaB/TsaD/TsaE complex responsible for the essential t6A tRNA-modification. Nucleic Acids Res., 46, 5850-5860.
  4. Pichard-Kostuch A.*, Zhang, W.*,  Liger, D., Daugeron, M., Letoquart, J.,  Gallay, I.,  Forterre, P., Collinet, B.,  van Tilbeurgh, H., Basta, T. (2018) Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal tRNA t6ARNA24, 926-938.
  5. Ferrandez, Y.*, Zhang, W.*, Peuroi, F., Akendengué, L., Blangy, A., Zeghouf, M. and Cherfils, J. (2017) Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule. Scientific Reports, 7:14409| DOI:10.1038/s41598-017-13619-2|1-13
  6. Zhang, W., Collinet, B., Perrochia, L., Durand, D. and van Tilbeurgh, H. (2015) The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli. Nucleic Acids Res.43, 1804-1817.
  7. Zhang, W., Collinet, B., Graille, M., Daugeron, M.C., Lazar, N., Libri, D., Durand, D. and van Tilbeurgh, H. (2015) Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Nucleic Acids Res.43, 3358-3372.
  8. Perrochia, L., Crozat, E., Hecker, A., Zhang, W., Bareille, J., Collinet, B., van Tilbeurgh, H., Forterre, P. and Basta, T. (2013) In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya. Nucleic Acids Res.41, 1953-1964.
  9. He, J., Shi, J., Xu, X., Zhang, W., Wang, Y., Chen, X., Du, Y., Zhu, N., Zhang, J., Wang, Q. et al. (2012) STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway. Journal of Biosciences37, 243-257.
  10. Jiang, P., Xu, X., Chen, Y., Zhang, W., Serradji, N., Yang, J., Dong, C. and Wang, Q. (2010) PMS-1077, a PAF antagonist, induced differentiation of HL-60 cells with its novel activity. Cell Biology International34, 1227-1230.
  11. Zhang, W., Lv, M., Hai, J., Wang, Q. and Wang, Q. (2010) Dicranostigma leptopodum (maxim) fedde induced apoptosis in SMMC-7721 human hepatoma cells and inhibited tumor growth in mice. Natural Science, 2, 457-463.
  12. Zhang, W., Yang, Y., Lin, C. and Wang, Q. (2010) Antioxidant attenuation of ROS-involved cytotoxicity induced by Paraquat on HL-60 cells. Health2, 235-261.
其它信息
更新:2019-11-26 | 访问:... | 二维码 | 维护教师主页