- Bio
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009-2013, Research fellow in the Univ. of Michigan/Howard Hughes Medical Institute
2013-2016, Professor of Cell Biology in Lanzhou Univ., Master's supervisor
2016- , Professor of Cell Biology in Lanzhou Univ., Master's and Doctoral supervisor
2022-，Associate Dean of the School of Life Sciences, Lanzhou University
- Academic Appointments
- Honors & Awards
- Funding
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Research Fundings：
1. Three National Natural Science Foundation of China grants
2. A few of the Fundamental Research Funds for the Central Universities
- Publications
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Representative peer-reviewed articles:
1. Overcoming cytoplasmic retention of GDOWN1 modulates global transcription and facilitates adaptation to cellular stresses. Zhu Z, Liu J, Feng H, Zhang Y, Huang R, Pan Q, Nan J, Miao R, Cheng B*. eLife, 2022, 11:e79116. doi: 10.7554/eLife.79116.
2. Mutant p53 in cancer: from molecular mechanism to therapeutic modulation. Chen X, Zhang T, Su W, Dou Z, Zhao D, Jin X, Lei H, Wang J, Xie X, Cheng B, Li Q, Zhang H, and Di C*. Cell Death & Disease, 2022, 13(11):974. doi: 10.1038/s41419-022-05408-1.
3. Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9. Zhang Y#, He F#, Zhang YN#, Dai Q, Li Q, Nan J, Miao R, Cheng B*. Mobile DNA, 2022, 13:25. doi: 10.1186/s13100-022-00279-x.
4. Evidence for the involvement of AtPiezo in mechanical responses. Fang X, Zhang Y, Cheng B, Luan S and He K*. Plant Signaling & Behavior, 2021, 16(5):1889252. doi: 10.1080/15592324.2021.1889252.
5. RNA polymerase II associated proteins regulate stomatal development through direct interaction with stomatal transcription factors in Arabidopsis thaliana. Chen L, Zhao M, Wu Z, Chen S, Rojo E, Luo J, Li P, Zhao L, Chen Y, Deng J, Cheng B, He K, Gou X, Li J and Hou S*. New Phytologist, 2021, 230(1):171-189. doi:10.1111/nph.17004.
6. A TAT peptide-based ratiometric two-photon fluorescent probe for detecting biothiols and sequentially distinguishing GSH in mitochondria. Su P, Zhu Z, Liang L, Wu W, Cao J*, Cheng B*, Liu W, Tang Y*. Talanta, 2020, 218, 121127. doi:10.1016/j.talanta.2020.121127.
7. A Smart Tumor-microenvironment Responsive Nanoprobe for Highly Selective and Efficient Combination Therapy. Fan Y, Guan S, Fang W, Li P, Hu B, Shan C, Wu W, Cao J*, Cheng B*, Liu W and Tang Y*. Inorganic Chemistry Frontiers, 2019, 6, 3562-3568. doi:10.1039/c9qi01076a.
8. Smart MMP2-Responsive Nanoprobe for Activatable Fluorescence Imaging-Guided Local Triple-Combination Therapies with Single Light. Hu B, Li P, Yang X, Fan Y, Shan C, Su P, Cao J, Cheng B*, Liu W*, Tang Y*. ACS Appl. Bio Mater., 2019, 2(7):2978-2987. doi:10.1021/acsabm.9b00321.
9. A Smart Photosensitizer–Cerium Oxide Nanoprobe for Highly Selective and Efficient Photodynamic Therapy. Fan Y, Li P, Hu B, Liu T, Huang Z, Shan C, Cao J*, Cheng B*, Liu W, Tang Y*. Inorganic Chemistry. 2019, 58(11):7295-7302. doi:10.1021/acs.inorgchem.9b00363.
10. Controlling the spatiotemporal expression of germ line specific genes by PRC1.6 complex. Sun X#, Li H#, Wang J, Cheng B*.HEREDITAS, 2019, 41(4):271-284. (Cover story) doi:10.16288/j.yczz.18-332.
11. Activatable Smart Nanoprobe for Sensitive Endogenous MMP2 Detection and Fluorescence Imaging Guided Phototherapies. Hu B#, Li P#, Zhang Y, Shan C, Su P, Cao J*, Cheng B*, Wu W, Liu W, Tang Y*. Inorganic Chemistry Frontiers, 2019, 6:820-828. doi:10.1039/c9qi00002j.
12. Surface Ligand Coordination Induced Self-assembly of Nanohybrid for Efficient Photodynamic Therapy and Imaging. Su P, Zhu Z, Fan Q, Cao J*, Wang Y, Yang X, Cheng B*, Liu W, Tang Y*. Inorganic Chemistry Frontiers, 2018, 5:2620-2629. doi:10.1039/C8QI00777B.
13. A biomolecule-based fluorescence chemosensor for sequential detection of Ag+ and H2S in 100% aqueous solution and living cells. Su P, Zhu Z, Wang J, Cheng B*, Wu W, Iqbal K, Tang Y*. Sensors & Actuators: B. Chemical, 2018, 273: 93-100. doi:10.1016/j.snb.2018.06.037.
14. Functionalized Eu(III)-Based Nanoscale Metal-Organic Framework To Achieve Near-IR-Triggered and -Targeted Two-Photon Absorption Photodynamic Therapy. Jia J, Zhang Y, Zheng M, Shan C, Yan H, Wu W, Gao X, Cheng B*, Liu W, Tang Y*. Inorganic Chemistry, 2018, 57 (1):300-310. doi:10.1021/acs.inorgchem.7b02475.
15. Structural and functional diversity of mammalian CBX proteins (in Chinese). Guan S, Wang J, Xie Y, Cheng B*. (Invited article) Sci Sin Vitae, 2017, 47(8):847-862. doi:10.1360/N052017-00012.
16. KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. Cheng B#, Ren X#, and Kerppola TK*. Molecular and Cellular Biology, 2014, 34(11):2075- 91. doi:10.1128/MCB.01729-13.
17. Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins. Ma R#, Zhang Y#, Sun T#, Cheng B*. (Invited article) Journal of Zhejiang University-Science B, 2014, 15(5):412-28. doi:10.1631/jzus.B1400077.
18. Functional association of Gdown1 with RNA polymerase II poised on human genes. Cheng B#, Li T#, Rahl PB, Adamson TE, Loudas NB, Guo J, Varzavand K, Cooper JJ, Hu X, Gnatt A, Young RA, Price DH*. (Cover story with a preview) Molecular Cell, 2012, 45(1): 38-50. doi:10.1016/j.molcel.2011. 10.022.
19. Isolation and functional analysis of RNA polymerase II elongation complexes. Cheng B, Price DH*. (Invited article) Methods, 2009, 48(4):346-52. doi:10.1016/j.ymeth.2009.02.026.
20. Analysis of factor interactions with RNA polymerase II elongation complexes using a new electrophoretic mobility shift assay. Cheng B, Price DH*. Nucleic Acids Research, 2008, 36(20):e135. doi:10.1093/nar/gkn630.
21. Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. Cheng B, Price DH*. Journal of Biological Chemistry, 2007, 282(30):21901-12. doi:10.1074 /jbc.M702936200.
Latest Time：2022-11-22