Contact

  • Title: Professor
  • Department: School of Life Sciences
  • Address: Room 447,Biological building
  • Tel: 0931-8915607
  • Fax: 0931-8915607
  • Email: sxzhang@lzu.edu.cn
  • Homepage:
Bio

2007-2009    Postdoctoral training, New York University, USA

2001-2007    Ph. D., The University of British Columbia, Canada   

1995-1998    M.S., Department of Biology, Lanzhou University, China

1991-1995    B.S., Department of Biology, Lanzhou University, China

Academic Appointments
Honors & Awards
Funding
Supported by grants from the National Natural Science Foundation of China
Publications

Publications:

          For most recent publications, please visit my ORCID profile: https://orcid.org/0000-0001-6524-9673

Xie, W., Gong, X.T., Cheng, X., Cao, J., Zhao, J., Zhang, H.L. & Zhang, S. (2021) LIMPID: a versatile method for visualization of brain vascular networks. Biomaterials Science.

Yang, Y.P., Qi, F.J., Qian, Y.P., Bao, X.Z., Zhang, H.C., Ma, B., Dai, F., Zhang, S.X. & Zhou, B. (2021) Developing Push-Pull Hydroxylphenylpolyenylpyridinium Chromophores as Ratiometric Two-Photon Fluorescent Probes for Cellular and Intravital Imaging of Mitochondrial NQO1. Analytical Chemistry 93:2385-2393.

Li, T., Zhao, J., Xie, W., Yuan, W., Guo, J., Pang, S., Gan, W.B., Gomez-Nicola, D. & Zhang, S. (2021) Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. Journal of Neuroinflammation 18:81.

Hu, G., Zhong, M., Zhao, J., Gao, H., Gan, L., Zhang, H., Zhang, S. & Fang, J. (2021) Fluorescent Probes for Imaging Protein Disulfides in Live Organisms. ACS Sensors 6:1384-1391.

Roth, S., Cao, J., Singh, V., Tiedt, S., Hundeshagen, G., Li, T., Boehme, J.D., Chauhan, D., Zhu, J., Ricci, A., Gorka, O., Asare, Y., Yang, J., Lopez, M.S., Rehberg, M., Bruder, D., Zhang, S., Gross, O., Dichgans, M., Hornung, V. & Liesz, A. (2021) Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity.

Wang, L., Zhu, L., Liu, J. & Zhang, S. (2020) Long-term high-resolution in vivo imaging of cerebral cortical structures following ischemic stroke. Biophysics Reports 6:127-136.

Liu, X., Shang, S., Chu, W., Ma, L., Jiang, C., Ding, Y., Wang, J., Zhang, S. & Shao, B. (2020) Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism. Journal of Pharmacy and Pharmacology 72:1110-1118.

Zhao, J., Qu, Y., Gao, H., Zhong, M., Li, X., Zhang, F., Chen, Y., Gan, L., Hu, G., Zhang, H., Zhang, S. & Fang, J. (2020) Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. Chemical Communications (Cambridge, England) 56:14075-14078.

Long, Y., Liu, J., Tian, D., Dai, F., Zhang, S. & Zhou, B. (2020) Cooperation of ESIPT and ICT Processes in the Designed 2-(2'-Hydroxyphenyl)benzothiazole Derivative: A Near-Infrared Two-Photon Fluorescent Probe with a Large Stokes Shift for the Detection of Cysteine and Its Application in Biological Environments. Analytical Chemistry 92:14236-14243.

Gong, X.T., Xie, W., Cao, J.J., Zhang, S., Pu, K. & Zhang, H.L. (2020) NIR-emitting semiconducting polymer nanoparticles for in vivo two-photon vascular imaging. Biomaterials Science 8:2666-2672.

Zhang, S. (2019) Microglial activation after ischaemic stroke. Stroke and Vascular Neurology 4:71-74.

Ju, F., Ran, Y., Zhu, L., Cheng, X., Gao, H., Xi, X., Yang, Z. & Zhang, S. (2018) Increased BBB Permeability Enhances Activation of Microglia and Exacerbates Loss of Dendritic Spines After Transient Global Cerebral Ischemia. Frontiers in Cellular Neuroscience 12:236.

Zhu, L., Wang, L., Ju, F., Khan, A., Cheng, X. & Zhang, S. (2017) Reversible recovery of neuronal structures depends on the degree of neuronal damage after global cerebral ischemia in mice. Experimental Neurology 289:1-8.

Zhu, L., Wang, L., Ju, F., Ran, Y., Wang, C. & Zhang, S. (2017) Transient global cerebral ischemia induces rapid and sustained reorganization of synaptic structures. Journal of Cerebral Blood Flow and Metabolism 37:2756-2767.

Khan, A., Ju, F., Xie, W., Tariq Hafeez, M., Cheng, X., Yang, Z., Zhu, L., Li, T. & Zhang, S. (2017) Transcriptomic analysis reveals differential activation of microglial genes after ischemic stroke in mice. Neuroscience 348:212-227.

Wang, C., Tao, S., Fang, Y., Guo, J., Zhu, L. & Zhang, S. (2016) Infiltrating cells from host brain restore the microglial population in grafted cortical tissue. Scientific Reports 6:33080.

Li, L., Du, Y., Ju, F., Ma, S. & Zhang, S. (2016) Calcium plays a key role in paraoxon-induced apoptosis in EL4 cells by regulating both endoplasmic reticulum- and mitochondria-associated pathways. Toxicology Mechanisms and Methods 26:211-20.

Li, T. & Zhang, S. (2016) Microgliosis in the Injured Brain: Infiltrating Cells and Reactive Microglia Both Play a Role. Neuroscientist 22:165-70.

Li, D., Guo, J., Zhou, X., Chang, C. & Zhang, S. (2016) The complete mitochondrial genome of Phrynocephalus helioscopus (Reptilia, Squamata, Agamidae). Mitochondrial DNA A DNA Mapp Seq Anal 27:1846-7.

Sun, C.-L., Liao, Q., Li, T., Li, J., Jiang, J.-Q., Xu, Z.-Z., Wang, X.-D., Shen, R., Bai, D.-C., Wang, Q., Zhang, S.-X., Fu, H.-B. & Zhang, H.-L. (2015) Rational design of small indolic squaraine dyes with large two-photon absorption cross section. Chemical Science 6:761-769.

Tang, P., Zhang, Y., Chen, C., Ji, X., Ju, F., Liu, X., Gan, W.B., He, Z., Zhang, S., Li, W. & Zhang, L. (2015) In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury. Scientific Reports 5:9691.

Wang, Y., Wang, Q., Lv, S. & Zhang, S. (2015) Different protein of Echinococcus granulosus stimulates dendritic induced immune response. Parasitology 142:879-89.

Zhang, Y., Zhang, L., Ji, X., Pang, M., Ju, F., Zhang, J., Li, W., Zhang, S., He, Z., Gan, W.B. & Tang, P. (2015) Two-photon microscopy as a tool to investigate the therapeutic time window of methylprednisolone in a mouse spinal cord injury model. Restorative Neurology and Neuroscience 33:291-300.

Liu, C.J., Du, B., Liu, N.F., Bao, S.J. & Zhang, S. (2014) Sex-specific parental care strategies via nestling age: females pay more attention to nestling demands than males do in the horned lark, Eremophila alpestris. Zoological Science 31:348-52.

Li, T., Pang, S., Yu, Y., Wu, X., Guo, J. & Zhang, S. (2013) Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain 136:3578-88.

Wang, J., Feng, X., Du, Y., Wang, L. & Zhang, S. (2013) Combination treatment with progesterone and rehabilitation training further promotes behavioral recovery after acute ischemic stroke in mice. Restorative Neurology and Neuroscience 31:487-99.

Lu, B., Li, T., Zhao, H., Li, X., Gao, C., Zhang, S. & Xie, E. (2012) Graphene-based composite materials beneficial to wound healing. Nanoscale 4:2978-82.

Zhang, S., Wang, J. & Wang, L. (2010) Structural plasticity of dendritic spines. Frontiers in Biology 5:48-58.

Bhatt, D.H., Zhang, S. & Gan, W.B. (2009) Dendritic spine dynamics. Annual Review of Physiology 71:261-82.

Zhang, S. & Murphy, T.H. (2007) Imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo. PLoS Biology 5:e119.

Enright, L.E., Zhang, S. & Murphy, T.H. (2007) Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo. Journal of Cerebral Blood Flow and Metabolism 27:1185-200.

Zhang, S., Boyd, J., Delaney, K. & Murphy, T.H. (2005) Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. Journal of Neuroscience 25:5333-8.

Zhang, S. & Murphy, T.H. (2004) Ca(2+)-independent spine dynamics in cultured hippocampal neurons. Molecular and Cellular Neurosciences 25:334-44.

Latest Time:2022-10-19