• Title: Associate Professor
  • Department: Institute of Biochemistry and Molecular Biology
  • Address: 盘旋路校区第二生物楼1108
  • Tel: 0931-8915322
  • Fax: 0931-8915322
  • Email:
  • Homepage:
  • 2000.8-2001.7,甘肃榆中恩玲中学,教师,研究生支教工作
  • 2006.7-2011.4,兰州大学生命科学学院,讲师
  • 2011.5-至今,兰州大学生命科学学院,副教授
Academic Appointments
Honors & Awards







  1. Jiang JH, He Z, Peng YL, Jin WD, Wang Z, Han RW, Chang M*, Wang R*. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 doi:10.1016/j.nlm.2015.05.010 (SCI)
  2. Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M*, Wang R*. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39-48. (SCI)
  3. Han RW, Xu HJ, Zhang RS, Wang P, Chang M, Peng YL, Deng KY, Wang R*. Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiol Learn Mem. 2014 ;107:32-6. (SCI)
  4. Han, RW, Zhang RS, Xu HJ, Chang M, Peng YL, Wang R*. Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Abeta42 in mice novel object and object location recognition tasks, Neuropharmacology, 2013;70:261-7.(SCI)
  5. Han RW, Zhang RS, Chang M, Peng YL, Wang P, Hu SQ, Choi CL, Yin M, Wang R*, Han YF. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Res. 2012;1470:59-68. (SCI)
  6. Peng YL, Zhang JN, Chang M, Li W, Han RW, Wang R*. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-83. (SCI)
  7. Peng YL, Han RW, Chang M, Zhang L, Zhang RS, Li W, Han YF, Wang R*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31(12):2259-63. (SCI)
  8. Chang M, Li W, Peng YL, Gao YH, Yao J, Han RW, Wang R*. Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6]γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain Res. 2009;1271:36-48. (SCI)
  9. Li W, Chang M, Peng YL, Gao YH, Zhang JN, Han RW, Wang R*. Neuropeptide S produces antinociceptive effect at the supraspinal level in mice. Regul. Pept. 2009;156:90-5. (SCI)
  10. Han RW, Chang M, Peng YL, Qiao LY, Yin XQ, Li W, Wang R*. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides. 2009;30(7): 1313-17. (SCI)
  11.  Han RW, Yin XQ, Chang M, Peng YLLi W, Wang R*. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment in mice morris water maze. Neuro. Lett. 2009;455:74-7. (SCI)
  12. Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R*. Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice. Peptides. 2009;30(2):234-40. (SCI)
  13. Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Regulation of Endochondral Ossification by Osteogenic Growth Peptide C-terminal Pentapeptide [OGP(10-14)]. Protein Pept. Lett. 2009;16:1074-80. (SCI)
  14. 常民, 彭雅丽, 李威, 王锐. 神经肽S的功能与构效关系研究进展. 生物物理学报. 2009;03:175-82.
  15. Li Z, Zhou LX, Zhang BH, Yan X, Li J, Peng YL, Chang M, Dong SL, Wang R*. Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell.Pharmazie. 2008;63(9):676-85.(SCI)
  16. Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept. 2007;142(1-2):16-23. (SCI)
  17. Peng YL, Chang M, Dong SL, Li W, Han RW, Fu GX, Chen Q, Wang R*. Novel potent agonist [(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 and antagonist [Nphe1,(pF)Phe4, Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 of nociceptin/orphanin FQ receptor. Regul. Pept. 2006;134:75-81. (SCI)
  18. Fang Q, Guo J, Peng YL, Chang M, He F, Chen Q, Wang R*. In vitro and in vivo studies of dansylated compounds, the putative agonists and antagonists on neuropeptide FF receptors. Peptides2006;27:1297-304. (SCI)
  19. Yang Q, Chen Y, Fu C, Chang M, Peng YL, Wang R*. Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.Protein Pept Lett. 2006;13(2):185-8.(SCI)


  1. 一种固液相缩合制备胸腺肽α1的方法,申请号:CN201310523706.1;
  2. 液相片段缩合制备胸腺肽α1的方法,申请号:CN201310523577.6;
  3. 片段缩合制备醋酸鲑鱼降钙素的方法,申请号: CN201410420967.5;
  4. 片段缩合制备特利加压素的方法,申请号: CN201410554759.4
  5. 一种片段缩合制备曲普瑞林的方法,申请号: CN201410743707.1
  6. 一种片段缩合制备醋酸去氨加压素的方法,申请号: CN201410748612.9
  7. 一种片段缩合制备醋酸阿托西班的方法,申请号: CN201410802681.3
  8. 片段缩合制备利拉鲁肽的方法,申请号:CN201510079168.0
Latest Time:2022-10-20