主持的省部级以上科研项目

1. 第二次青藏高原综合科学考察研究专题（2021QZKK0204，2021-2024年）：青藏地区特定交通廊道生态风险评估
2. 国家自然科学基金面上项目（31670517，2017-2020年）：2,4-二氯酚对斑马鱼性别分化的毒性效应及机制研究
3. 甘肃省自然科学基金面上项目（1606RJZA080，2016-2018年）：DNA甲基化对镉促细胞增殖的调控机制研究
4. 教育部新世纪优秀人才支持计划（NCET-10-0464, 2011-2013年）：水环境中氯酚类污染的生物监测和风险评价研究
5. 甘肃省自然科学研究基金计划（1107RJZA262，2011-2013年）：茶多酚抗镉诱导的细胞凋亡作用机理研究
6. 国家自然科学基金青年项目（20907019，2010-2012年）：2,4-二氯酚对鲫鱼的遗传毒性效应及作用途径研究
7. 教育部高校博士点专项科研基金（20090211120001， 2010-2012年）：氯酚类污染物对鱼类的分子毒理学影响研究
8. 甘肃省科技支撑计划项目（090NKCA078，2009-2011年）：甘肃黄灌区生态去污及农业清洁生产模式研究

参与的科研项目

1. 国家自然科学基金项目（41171391，2012-2015年）：黄河上游农业生态系统中复合污染物的环境过程及生态效应
2. 国家科技支撑计划项目课题（2009BAC53B03，2009-2012年）：黄河重要水源补给区(玛曲)生态修复及保护技术集成研究与示范
3. 国家自然科学基金项目（30770390，2008-2010年）：黄河灌溉区湿地污水处理系统的建立及农业生态恢复研究

本科生教学：甘肃省线下一流课程《动物生物学》课堂讲授；曾参与《资源生物学（动物学）》理论教学及《动物生物学实验》和《生物学野外实习》的实践教学工作。

研究生教学：主讲《动物毒理学》和《遗传毒理学》；合讲《生态毒理学》和《环境动物学》。

指导在读硕士研究生5人，博士生4人；毕业硕士研究生10人。

环境动物学、环境毒理学、生态毒理学、遗传毒理学

       主要研究重金属铅镉和有机物氯酚等环境污染物对动物的影响效应，在此基础上，利用特定的细胞株、斑马鱼或小鼠等为模型，通过细胞培养、动物活体染毒、免疫组化、DNA电泳、流式细胞术、蛋白杂交、RNA干扰、荧光定量PCR、基因编辑等现代生物学方法，揭示污染物对动物体或细胞产生毒性影响的具体信号途径及作用机制。

       已主持或完成国家自然科学基金项目、科技部第二次青藏高原综合科学考察研究专题、甘肃省科技支撑计划项目、甘肃省自然科学基金项目、教育部新世纪人才项目和教育部博士点新教师类项目等12项；作为主要参与人完成国家科技支撑计划项目子课题1项、国家自然科学基金项目3项；已在国际一流学术期刊Environmental Science & Technology, Journal of Hazardous Materials, Science of the Total Environment, Ecotoxicology and Environmental Safety, Journal of Environmental Sciences, Aquatic Toxicology等发表论文45篇，其中第一作者和通讯作者SCI论文20篇，TOP期刊论文8篇，高被引论文2篇，大类一区和二区论文13篇，SCI论文他引次数1200余次（Web of Science数据库），H指数为17。

教育部新世纪优秀人才(2010)

兰州大学“生命科学学院与口腔医学院青年教师联合讲课比赛”二等奖（2016）

兰州大学优秀党务工作者（2018）

兰州大学110周年校庆工作先进个人（2019）

兰州大学生命科学学院优秀党务工作者（2021）

代表性论文（^* 通讯作者） For more publications, please visit my ORCID profile.

1. 1. Yan Hu, Xuan Ma, Rongjian Liu, Iqra Mushtaq, Yongmei Qi, Cong Yuan, and Dejun Huang*. 2022. 2,4-Dichlorophenol Increases Primordial Germ Cell Numbers via ESR2a-Dependent Pathway in Zebrafish Larvae. Environmental Science & Technology. 56, 13878-13887. (SCI, TOP期刊, IF 11.357)
   
2. 2. Yongmei Qi, Lin Ma, Sajid Naeem, Xueyan Gu, Xijuan Chao, Cong Yuan, Dejun Huang*, 2021. Pb induced mitochondrial fission of fibroblast cells via ATM activation. Journal of Hazardous Materials, 416: 126177. (SCI, TOP期刊, IF 14.224) (Full Text)
3. 3. Yan Hu, Dong Li, Xuan Ma, Rongjian Liu, Yongmei Qi, Cong Yuan, Dejun Huang*. 2021. Effects of 2,4-dichlorophenol exposure on zebrafish: Implications for the sex hormone synthesis, Aquatic Toxicology, 236: 105868. (SCI, TOP期刊, IF 4.346) (Full Text)
4. 4. Jiangyuan Han, Yan Hu, Yongmei Qi, Cong Yuan, Sajid Naeem, Dejun Huang*. 2021. High temperature induced masculinization of zebrafish by down-regulation of sox9b and esr1 via DNA methylation, Journal of Environmental Sciences, 107: 160-170. (SCI, IF 4.302) (Full Text)
5. 5. Xingjie Zhang, Lin Ma, Yue Tang, Jiangyuan Han, Yongmei Qi*, Dejun Huang*. 2021. Low-dose cadmium exposure facilitates cell proliferation by promoter hypermethylation of RASSF1A and DAPK1 genes. Environmental Toxicology. 36 (11) : 2313-2321. (SCI, IF 4.119) (Full text)
6. 6. Chen Zhang, Dong Li, Tingting Ge, Jiangyuan Han, Yongmei Qi*, Dejun Huang*. 2020. 2,4-Dichlorophenol induces feminization of zebrafish (Danio rerio) via DNA methylation. Science of the Total Environment. 708: 135084  (SCI, TOP期刊, IF 6.551) (Full Text)
7. 7. Cong Yuan, Chen Zhang, Yongmei Qi, Dong Li, Yan Hu, Dejun Huang*. 2020. 2,4-Dichlorophenol induced feminization of zebrafish by down-regulating male-related genes through DNA methylation. Ecotoxicology and Environmental Safety. 189: 110042.  (SCI, IF 4.872) (Full Text)
8. 8. Dejun Huang, Xiaoning Zhang, Chen Zhang, Hui Li, Dong Li, Yan Hu, Feng Yang, Yongmei Qi. 2018. 2,4-Dichlorophenol induces DNA damage through ROS accumulation and GSH depletion in goldfish Carassius auratus. Environ Mol Mutagen. 59: 798-804. (SCI, IF 3.254) (Full Text)
9. 9. Tingting Ge, Jiangyuan Han, Yongmei Qi, Xueyan Gu, Lin Ma, Chen Zhang, Sajid Naeem, Dejun Huang*. 2017. The toxic effects of chlorophenols and associated mechanisms in fish. Aquatic Toxicology. 184: 78-93. (SCI, TOP期刊, IF 3.557)（Highly Cited Papers, 高被引论文）(Full Text)
10. 10. Bailin Liu, Shiwei Ai, Wenya Zhang, Dejun Huang, Yingmei Zhang^*. 2017. Assessment of the bioavailability, bioaccessibility and transfer of heavy metals in the soil-grain-human systems near amining and smelting area in NW China. Science of the Total Environment. 609: 822-829. (SCI, TOP期刊, IF 6.551）(Full Text)
11. 11. Xiaoning Zhang, Xiaona Zhang, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2016. 2,4-Dichlorophenol induces ER stress-mediated apoptosis via eIF2a dephosphorylation in vitro. Environmental Toxicology. 31(2):245-255. (SCI, IF 3.197) (Full Text)
12. 12. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Jufang Wang, Dejun Huang*. 2015. Cadmium delays non-homologous end joining (NHEJ) repair viainhibition of DNA-PKcs phosphorylation and downregulation ofXRCC4 and Ligase IV. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 779:112-123. (SCI, IF 3.680) (Full Text)
13. 13. Xiaoning Zhang, Xiaona Zhang, Zhidan Niu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2014. 2,4,6-Trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis. International Journal of Toxicology. 33(6): 532-541. (SCI, IF1.382) (Full Text)
14. 14. Xiaoning Zhang, Hui Li, Qian Qiu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2013. 2,4-Dichlorophenol induces global DNA hypermethylation through the increase of S-adenosylmethionine and the upregulation of DNMTs mRNA in the liver of goldfish Carassius auratus. Comparative Biochemistry and Physiology-Part C: Toxicology & Pharmacology. 160C: 54-59. (SCI, IF 2.764) (Full Text)
15. 15. Hui Li, Xiaoning Zhang, Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2013. 2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway. Aquatic Toxicology. 140-141: 117-122. (SCI, TOP期刊, IF 3.513) (Full Text)
16. 16. Christophe Redon, Urbain Weyemi, Palak Parekh, Dejun Huang, Allison Burrell, William Bonner^*. 2012. γ-H2AX and other histone post-translational modifications in the clinic. Biochim Biophys Acta. 1819(7): 743-56.(SCI, IF 3.411) (Full Text)
17. 17. Zhuoyi Xie, Yingmei Zhang, Ailing Li, Ping Li, Weihong Ji, Dejun Huang^*. 2010. Cd-induced apoptosis was mediated by the release of Ca²⁺ from intracellular Ca storage. Toxicology Letters. 192(2): 115-118. (SCI, IF 3.249) (Full Text)
18. 18. Dejun Huang, Yingmei Zhang, Yongmei Qi, Che Chen, Weihong Ji. 2008. Global DNA hypomethylation, rather than reactive oxygen species (ROS), a potential facilitator of Cadmium-stimulated K562 cell proliferation. Toxicology Letters. 179(1): 43-47. (SCI, IF 3.249) (Full Text)
19. 19. Dejun Huang, Yingmei Zhang, Yejing Wang, Zhuoyi Xie, Weihong Ji. 2007. Assessment of the genotoxicity in toad Bufo raddei exposed to petrochemical contaminants in Lanzhou Region, China. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 629 (2): 81-88. (SCI, IF 2.363) (Full Text)
20. 20. Dejun Huang, Yingmei Zhang, Gang Song, Jing Long, Jianghai Liu, Weihong Ji. 2007. Contaminants-induced oxidative damage on the carp Cyprinus carpio collected from the upper Yellow River, China. Environmental Monitoring and Assessment.128: 483-488 (SCI, IF 1.035) (Full Text)