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吉尚戎

个人简历

科研成果

教学情况

研究方向

荣誉奖励

论文专著

个人简历

基本信息

职称:教授

办公室地址:1214

邮箱:jsr@lzu.edu.cn

学习经历

1994~1998,北京大学,医学部,学士

1998~2003,清华大学,生物系,博士

工作经历

2003至今,兰州大学,生命科学学院,教授

社会工作

中国生化与分子生物学会,蛋白质专业委员会,委员;

甘肃省生理学会,理事。

科研成果

先后主持国家自然科学基金、教育部新世纪优秀人才支持计划、重点项目、博士点基金等十余项。

教学情况

研究方向

重要急性期蛋白的生物发生、功能机制及诊疗应用

荣誉奖项

国家自然科学奖二等奖(5/5)。

论文专著

1.     Wang M.-Y., Zhang C.-M., Zhou H.-H., Ge Z.-B., Su C.-C., Lou Z.-H., Zhang X.-Y., Xu T.-T., Li S.-Y., Zhu L., Zhou Y.-L., Wu Y.*, Ji S.-R.* (2022) Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein. Journal of Biological Chemistry, 298(8): 102160. (IF 5.486)

2.     Cheng B., Lv J.-M., Liang Y.-L., Zhu L., Huang X.-P., Li H.-Y., Potempa L.A., Ji S.-R.*, Wu Y.* (2022) Secretory quality control constrains functional selection-associated protein structure innovation. Communications Biology, 5: 268. (IF 6.548)

3.     Li H.-Y., Tang Z.-M., Wang Z., Lv J.-M., Liu X.-L., Liang Y.-L., Cheng B., Gao N., Ji S.-R.*, Wu Y.* (2022) C-reactive protein protects against acetaminophen-induced liver injury by preventing complement overactivation. Cellular and Molecular Gastroenterology and Hepatology, 13(1): 289-307. (IF 8.797)

4.     Wang M.-Y., Zhou H.-H., Zhang C.-M., Su H.-X., Li S.-L., Ji S.-R., Liu E.-Q.*, Wu Y.* (2020) A functional genetic variant at C-reactive protein promoter (rs3091244) is not associated with cancer risk in a Chinese population. Frontiers in Immunology, 11: 926. (IF 8.786)

5.     Zhang S.-C., Wang M.-Y., Feng J.-R., Chang Y., Ji S.-R.*, Wu Y.* (2020) Reversible promoter methylation determines fluctuating expression of acute phase proteins. eLife, 9: e51317. (IF 8.713)

6.     Zhang L., Shen Z.-Y., Wang K., Li W., Shi J.-M., Osoro E.K., Ullah N., Zhou Y., Ji S.-R.* (2019) C-reactive protein exacerbates epithelial-mesenchymal transition through Wnt/b-catenin and ERK signaling in streptozocin-induced diabetic nephropathy. FASEB Journal, 33(5): 6551-6563. (IF 5.834)

7.     Shi J.-M., Lv J.-M., Gao B.-X., Zhang L.*, Ji S.-R.* (2019) Endosomal pH favors shedding of membrane-inserted amyloid-β peptide. Protein Science, 28(3): 889-899. (IF 6.993)

8.     Li H.-Y., Liu X.-L., Liu Y.-T., Jia Z.-K., Filep J.G., Potempa L.A., Ji S.-R.*, Wu Y.* (2019) Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein. Cardiovascular Research, 115(2): 440-452. (IF 13.081)

9.  Zhang L., Li H.-Y., Li W., Shen Z.-Y., Wang Y.-D., Ji S.-R.*, Wu Y.* (2018) An ELISA assay for quantifying monomeric C-reactive protein in plasma. Frontiers in Immunology, 9: 511. (IF 8.786)

10.  Jia Z.-K., Li H.-Y., Liang Y.-L., Potempa L.A., Ji S.-R.*, Wu Y.* (2018) Monomeric C-reactive protein binds and neutralizes receptor activator of NF-κB ligand-induced osteoclast differentiation. Frontiers in Immunology, 9: 234. (IF 8.786)

11.  Lv J.-M., Lv S.-Q., Liu Z.-P., Zhang J., Gao B.-X., Yao Z.-Y., Wu Y.-X., Potempa L.A., Ji S.-R.*, Long M.*, Wu Y.* (2018) Conformational folding and disulfide bonding drive distinct stages of protein structure formation. Scientific Reports, 8: 1494. (IF 4.996)

12.  Li H.-Y., Wang J., Meng F., Jia Z.-K., Su Y., Bai Q.-F., Lv L.-L., Ma F.-R., Potempa L.A., Ji S.-R.*, Wu Y.* (2016) An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein. Journal of Biological Chemistry, 291(16): 8795-8804. (IF 5.486)

13.  Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*, Wu Y.* (2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. Journal of Immunology, 194(11): 5243-5252. (IF 5.426)

14.  Su H.-X., Zhou H.-H., Wang M.-Y., Cheng J., Zhang S.-C., Hui F., Chen X-Z, Liu S.-H., Liu Q.-J., Zhu Z.-J., Hu Q.-R., Wu Y.*, Ji S.-R.* (2014) Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk. Plos One, 9(7): e102418. (IF 3.752)

15.  Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A., Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses. Journal of Biological Chemistry, 289(20): 14283-14290. (IF 5.486)

16.  Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*, Wu Y.* (2014) Recurrent mutations at C-reactive protein gene promoter SNP position -286 in human cancers. Cell Research, 24(4): 505-508. (IF 46.297)

17.  Ma X, Ji S.-R., Wu Y.* (2013) Regulated conformation changes in C-reactive protein orchestrate its role in atherogenesis. Science Bulletin, 58(14): 1642-1649. (IF 20.577)

18.  Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y., Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. Journal of Biological Chemistry, 287(1): 748-756. (IF 5.486)

19.  Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*, Wu Y.* (2011) A redox switch in C-reactive protein modulates activation of endothelial cells. FASEB Journal, 25(9): 3186-3196. (IF 5.834)

20.  Zhu L., Chen L., Zhou X.-M., Zhang Y.-Y., Zhang Y.-J., Zhao J., Ji S.-R., Wu J.-W.*, Wu Y.* (2011) Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure, 19(4): 515-522. (IF 5.871)

21.  Liu R.-Q., Zhou Q.-H., Ji S.-R., Zhou Q., Feng D., Wu Y., Sui S.-F.* (2010) Membrane localization of β-Amyloid 1–42 in lysosomes: a possible mechanism for lysosome labilization. Journal of Biological Chemistry, 285(26): 19986-19996. (IF 5.486)

22.  Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J., Wu Y.* (2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. FASEB Journal, 23(6): 1806-1816. (IF 5.834)

23.  Ji S.-R., Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm. FASEB Journal, 21(1): 284-294. (IF 5.834)

24.  Ji S.-R., Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4): 935-941. (IF 10.514)

25.  Ji S.-R., Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis. International Journal of Biochemistry & Cell Biology, 384(4): 648-661. (IF 5.652)

26.  Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087. (IF 12.779)

27.  Ji S.-R., Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation. Journal of Biological Chemistry, 277(8): 6273-6279. (IF 5.486)

28.  Wu Y., Wang H.-W., Ji S.-R., Sui S.-F.* (2003) Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits. Acta Crystallographica Section D-Biological Crystallography, 59(5): 922-926. (IF 5.699)

29.  Wu Y., Ji S.-R., Wang H.-W., Sui S.-F.* (2002) Study of the spontaneous dissociation of rabbit C-reactive protein. Biochemistry (Moscow), 67(12): 1377-1382. (IF 2.824)

30.  Ji S.-R., Wu Y., Sui S.-F.* (2002) Study of beta-amyloid peptide (Abeta40) insertion into phospholipid membranes using monolayer technique. Biochemistry (Moscow), 67(11): 1283-1288. (IF 2.487)

31.  Ji S.-R., Wu Y., Sui S.-F.* (2002) Study of the correlation of secondary structure of beta-amyloid peptide (Abeta40) with the hydrophobic exposure under different conditions. General Physiology and Biophysics, 21(4): 415-427. (IF 2.824)

最新更新时间: 2022-11-15