国家自然科学基金委面上项目：吲哚调节荧光假单胞菌耐药性及莫匹罗星合成的分子机制研究（31971422），执行时间：2020/01-2023/12

国家自然科学基金委面上项目：毒素-抗毒素MqsRA调控荧光假单胞菌抗药性的分子机制研究(31972319)，执行时间：2020/01-2023/12

国家自然科学基金委面上项目：植物根际促生菌Pseudomonas-fluorescems 2P24感受与影响类黄酮的分子机制研究，执行时间：2018/01-2021/12

国家自然科学基金委青年项目：荧光假单胞杆菌中的抗生素DAPG合成酶的晶体结构及其催化机理，2014/01-2016/12

甘肃省自然科学基金面上项目：黄酮类物质对雄激素受体信号转导的拮抗机制研究，2019年/01-2020/12

国家自然科学基金委面上项目：2,4-DAPG及MAPG作为荧光假单胞菌信号分子的作用机制，执行时间：2020/01-2023/12 承担经费：22万

2019年甘肃医学科技奖一等奖，排名5/9

2019年甘肃省科技进步二等奖，排名7/10

发表论文(#通讯作者）：

Luo L-M, Xu H, Zhang N, Ge H, Xiang Y, Yang H#, He Y-X#. Pyoluteorin regulates the biosynthesis of 2,4-DAPG through the TetR family transcription factor PhlH in Pseudomonas protegens Pf-5. Appl Environ Microbiol. 2024 Mar 12:e0174323.

Zhang S-P, Ye Y-P, Hou J, Ye Z-R, Wang Z-S, Yu X-Q, Guo D-D, Wang Y#, He Y-X#. Antitoxin MqsA decreases antibiotic susceptibility through the global regulator AgtR in Pseudomonas fluorescens. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0081223

Jia W, Zhong L, Ren Q, Teng D, Gong L, Dong H, Li J, Wang C, He YX#, Yang J#. Microcystin-RR promote lipid accumulation through CD36 mediated signal pathway and fatty acid uptake in HepG2 cells. Environ Res. 2024 Feb 2;249:118402.

Song Y, Zhang S, Zhao N, Nong C, He YX#, Bao R#. Pseudomonas aeruginosa two-component system CprRS regulates HigBA expression and bacterial cytotoxicity in response to LL-37 stress. PLoS Pathog. 2024 Jan 10;20(1):e1011946

Zhao NL, Zhu ZQ, Feng HZ, Song YJ, Huang Q, Mou XY, Nong C, He YX#, Bao R#. Host-derived peptide signals regulate Pseudomonas aeruginosa virulence stress via the ParRS and CprRS two-component systems. J Hazard Mater. 2023 Oct 15;460:132512

         Xu T, Tao X, He H, Kempher ML, Zhang S, Liu X, Wang J, Wang D, Ning D, Pan C, Ge H, Zhang N#, He YX#, Zhou J#. Functional and structural diversification of incomplete phosphotransferase system in cellulose-degrading clostridia. ISME J. 2023 Jun;17(6):823-835

Song Y, Zhang S, Ye Z, Song Y, Chen L, Tong A, He YX#, Bao R#. The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur. Nucleic Acids Res. 2022 Oct 14;50(18):10586-10600

Zhang N, Wu J, Zhang S, Yuan M, Xu H, Li J, Zhang P, Wang M, Kempher ML, Tao X, Zhang LQ, Ge H#, He YX#. Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules. J Biol Chem. 2022 Jun;298(6):102027

Li DY, Han JT, Zhang MY, Yan X, Zhang N, Ge H, Wang Z#, He YX#. The Two-Component System RstA/RstB Regulates Expression of Multiple Efflux Pumps and Influences Anaerobic Nitrate Respiration in Pseudomonas fluorescens. mSystems. 2021 Nov 2;6(6):e0091121

Feng Y, Lu Y, Li J, Zhang H, Li Z, Feng H, Deng X, Liu D, Shi T, Jiang W, He YX#, Zhang J#, Wang Z#. Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo. Eur J Med Chem. 2022 Jan 5;227:113888

Song Y*, Zhang SP*, Luo G, Shen Y, Li C, Zhu Y, Huang Q, Mou X, Tang X, Liu T, Wu S, Tong A, He YX#, Bao R#. Type II Antitoxin HigA Is a Key Virulence Regulator in Pseudomonas aeruginosa. ACS Infect Dis. 2021 Oct 8;7(10):2930-2940

Han JT, Zhu Y, Pan DB, Xue HX, Wang S, Peng Y, Liu H#, He YX#, Yao X#. Discovery of pentapeptide-inhibitor hits targeting FKBP51 by combining computational modeling and X-ray crystallography. Comput Struct Biotechnol J. 2021 Jul 21;19:4079-4091

Zhang SP, Feng HZ, et al. Feng HY#, He YX# Proteomic analysis reveals the mechanism of different environmental stress -induced tolerance of Pseudomonas aeruginosa PAO1 to monochloramine disinfection. J Hazard Mater. 2021 Sep 5;417:126082.

Han JT, Li DY, Zhang MY, Yu XQ, Jia XX, Xu H, Yan X, Jia WJ, Niu S, Kempher ML, Tao X, He YX#. EmhR is an indole-sensing transcriptional regulator responsible for the indole-induced antibiotic tolerance in Pseudomonas fluorescens. Environ Microbiol. 2021 Apr;23(4):2054-2069

Li T*, Song Y*, et al. He YX, Bao R. Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from Pseudomonas aeruginosa. mBio. 2021 Feb 23;12(1):e03299-20.

Song Y, Luo G, Zhu Y, Li T, Li C, He L, Zhao N, Zhao C, Yang J, Huang Q, Mu X, Tang X, Kang M, Wu S, He YX#, Bao R#. Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs. Environ Microbiol. 2021 Mar;23(3):1541-1558

Zhang SP, Feng HZ, Wang Q, Kempher ML, Quan SW, Tao X, Niu S, Wang Y, Feng HY#, He YX#. Bacterial type II toxin-antitoxin systems acting through post-translational modifications. Comput Struct Biotechnol J. 2020 Dec 11;19:86-93.

Guo DD*, Luo LM* et al. He YX# The regulator PltZ regulates a novel antibiotic efflux pump PltIJKNOP of Pseudomonas aeruginosa ATCC 27853 in response to the antimicrobial 2,4-diacetylphloroglucinol. Front Microbiol. 2020 Jul 8;11:1423

Yu XQ*, Yan X*. et al. He YX# Flavonoids repress production of antifungal 2,4-DAPG but potentially facilitate root colonization of the rhizobacterium Pseudomonas fluorescens. Environ Microbiol. 2020 Dec;22(12):5073-5089

Zhang SP, Wang Q, Quan SW, Yu XQ, Wang Y, Guo DD, Peng L, Feng HY#, He YX# Type II toxin-antitoxin system in bacteria: activation, function and mode of action. Biophysical Reports. 2020

Na M, Zhang S, Liu J, Ma S, Han Y, Wang Y, He YX, Chen H, Chen X. Determination of pathogenic bacteria-Bacillus anthrax spores in environmental samples by ratiometric fluorescence and test paper based on dual-emission fluorescent silicon nanoparticles. J Hazard Mater. 2020 Mar 15;386:121956

Zhang ZY, Bai HH, Guo Z, Li HL, He YT, Duan XL, Suo ZW, Yang X, He YX, Hu XD. mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice. PLoS Biol. 2019 Aug 21;17(8)

Han JT*, Zhang SP*, Jia WJ, Zhang Z, Wang Y, He YX#. Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus. FEBS Journal. 2019

Wang Y*, Zhang SP*, Zhang MY, Kempher ML, Guo DD, Han JT, Tao X, Wu Y, Zhang LQ, He YX#. The antitoxin MqsA homolog in Pseudomonas fluorescens 2P24 has a rewired regulatory circuit through evolution. Environ Microbiol. 2019

Zhao JH, Chen JH, Wang Y, Wang ZP#, He YX#. The putative compatible solute-binding protein ProX from Mycobacterium tuberculosis H37Rv: biochemical characterization and crystallographic data. Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):231-235.

Yan X, Yang R, Zhao RX, Han JT, Jia WJ, Li DY, Wang Y, Zhang N, Wu Y, Zhang LQ#, He YX#. The transcriptional regulator PhlH modulates 2,4-diacetylphloroglucinol biosynthesis in response to the biosynthetic intermediate and end product. Appl Environ Microbiol. 2017 Aug 18

Li L, Zhu Y, Zhou S, An X, Zhang Y, Bai Q, He YX#, Liu H#, Yao XJ#. Experimental and Theoretical Insights into the Inhibition Mechanism of Prion Fibrillation by Resveratrol and its Derivatives. ACS Chem Neurosci. 2017 Aug 17

Sun C, Yan K, Han JT, Tao L, Lv MH, Shi T, He YX, Wierzba M, Tax FE, Li J.Scanning for New BRI1 Mutations via TILLING Analysis. Plant Physiol. 2017 Jul;174(3):1881-1896.

Nan Q, Qian D, Niu Y, He YX, Tong S, Niu Z, Ma J, Yang Y, An L, Wan D, Xiang Y. Plant Actin-depolymerizing Factors Possess Opposing Biochemical Properties Arising From Key Amino Acid Changes Throughout Evolution. Plant Cell. 2017 Jan 25

Wu D, Tao X, Chen ZP, Han JT, Jia WJ, Zhu N, Li X, Wang ZP#, He YX#. The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells. J Hazard Mater. 2016 Apr 15;307:193-201