科研项目：

中央高校基本科研业务费，基础研究自由探索项目（2019-2020）：小神经胶质细胞的时间生物学初步探索（No. lzujbky-2019-74） -主持

甘肃省自然科学基金项目, 23JRRA1040, 环境镍暴露致神经血管单元毒性效应及机制研究, 2023至 2026 -主持

兰州大学科研启动经费项目（2019-2024）（No. 561119201）-主持

德国Helmholtz funding programme，BioInterfaces in Technology and Medicine (BIFTM)，Function, expression, and regulation of ‘circadian clock’ genes that govern diurnal rhythms. -参加

指导本科生团队获得2021 年全国大学生生命科学竞赛科学探究类甘肃省二等奖、全国三等奖；

指导本科生团队获得2021年全国大学生生命科学竞赛创新创业类全国二等奖；

协助指导本科毕业论文一项（籍雨鑫同学，优秀）；

指导研究生获得2021年硕士研究生国家奖学金（王左同学）、甘肃省2021年度优秀研究生“创新之星”项目（李珂敏、王左、宋赞三名同学）、兰州大学2022 届优秀毕业生（徐嫣艺同学，已赴中科大-中科院合肥物质科学研究所攻读博士学位）、兰州大学2023届优秀毕业生和蔡司科学研究优秀论文奖学金（王左同学）；

欢迎对发育神经生物学和动物生理学研究（以小型鱼类模式动物、小鼠，plus新奇生物洞穴鱼为主要研究模型）感兴趣的同学报考研究生。

硕士研究生招生方向：发育神经生物学
注：硕士研究生招生专业为发育生物学(071008)

主要从事动物发育神经生物学、动物生理学相关领域研究工作：

（1）脊椎动物光生物学研究：以鱼类模式动物（斑马鱼和洞穴鱼）为主要模型探讨环境中的光照对昼夜节律生物钟与DNA损伤修复系统功能与进化的影响及机制；以小鼠、斑马鱼和青鳉为模型探讨长、短光周期，以及睡眠、昼夜节律紊乱对脊椎动物中枢神经系统结构、功能的效应及其分子、细胞机制。

（2）发育、神经毒理学研究：利用模式动物斑马鱼在活体神经成像、高通量行为检测、遗传学分析等方面的显著优势，开展主要、新型环境污染物、生物制剂的发育、神经毒性效应及其分子、细胞机制研究。

（3）开展动物遗传变异与功能基因组学合作研究

欢迎对发育神经生物学和动物生理学研究（以小型鱼类模式动物、小鼠，plus新奇生物洞穴鱼为主要研究模型）感兴趣的同学报考研究生。

Haiyu Zhao, Hongxiang Li, Juan Du, Giuseppe Di Mauro, Sebastian Lungu-Mitea, Nathalie Geyer, Daniela Vallone, Cristiano Bertolucci, Nicholas S. Foulkes*. Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair. PLoS Genetics, 2021 Feb 5;17(2):e1009356. doi: 10.1371/journal.pgen.1009356. Epub ahead of print. PMID: 33544716.（得到中国斑马鱼信息中心的报道）

Haiyu Zhao; Giuseppe Di Mauro; Sebastian Lungu Mitea; Pietro Negrini; Andrea Maria Guarino; Elena Frigato; Thomas Braunbeck; Hongju Ma; Tilman Lamparter; Daniela Vallone; Cristiano Bertolucci; Nicholas S Foulkes^*, Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness, Current Biology, 2018.10, 28(20): 3229~3243.e4.（得到包括Discover，National Geographic, Science Daily等众多国际媒体的采访报道，Current Biology期刊针对此论文发表了同期综述评论文章“Evolution: A Dark Past”）

Jose Fernando López-Olmeda#, Haiyu Zhao#, Markus Reischl, Christian Pylatiuk, Tyrone Lucon-Xiccato, Felix Loosli*, Nicholas S. Foulkes*. Long photoperiod impairs learning in male but not female medaka. iScience, 2021.24(7):102784. （共同第一作者）

Junru Liu; Yanyi Xu; Yuxin Ji; Kemin Li; Shuang Wang; Bixi Zhao; Jiayi Ruan; Nicholas S. Foulkes; Shengxiang Zhang; Haiyu Zhao ; Sustained microglial activation and accelerated elimination of dendritic spines during acute sleep deprivation and restoration, The Innovation Life, 2023, 1(3): 100037.  （通讯作者）

Zuo Wang; Kemin Li; Yanyi Xu; Zan Song; Xianyong Lan; Chuanying Pan; Shengxiang Zhang; Nicholas S. Foulkes; Haiyu Zhao ; Ferroptosis contributes to nickel-induced developmental neurotoxicity in zebrafish, Science of The Total Environment, 2023, 858: 160078. （通讯作者）

Zuo Wang; Yi Bi; Kemin Li; Zan Song; Chuanying Pan; Shengxiang Zhang; Xianyong Lan; Nicholas S. Foulkes; Haiyu Zhao ; Nickel oxide nanoparticles induce developmental neurotoxicity in zebrafish by triggering both apoptosis and ferroptosis, Environmental Science: Nano, 2023, 10: 640-655. （通讯作者）

Zuo Wang, Haiyu Zhao*, Yanyi Xu, Jianing Zhao, Zan Song, Yi Bi, Yang Li, Xianyong Lan, Chuanying Pan, Nicholas S. Foulkes, Shengxiang Zhang. Early-life lead exposure induces long-term toxicity in the central nervous system: From zebrafish larvae to juveniles and adults, Science of The Total Environment, 2022, 804: 150185. （通讯作者）

Yanyi Xu, Haiyu Zhao*, Zuo Wang, Hao Gao, Junru Liu, Kemin Li, Zan Song, Cong Yuan, Xianyong Lan, Chuanying Pan, Shengxiang Zhang*. Developmental exposure to environmental levels of cadmium induces neurotoxicity and activates microglia in zebrafish larvae: From the perspectives of neurobehavior and neuroimaging, Chemosphere, 2022. （共同通讯作者）

Weifeng Chen#; Jialu Shen#; Zuo Wang#; Xiang Liu*; Yanyi Xu; Haiyu Zhao*; Didier Astruc*. Turning waste into wealth: facile and green synthesis of carbon nanodots from pollutants and applications to bioimaging. Chemical Science, 2021, Advance Article. (共同通讯作者)

Liping Zhang, Xiuru Bi, Zuo Wang, Ali Serol Ertürk, Gökhan Elmaci, Haiyu Zhao*, Peiqing Zhao*, Xu Meng*. Brønsted-acid sites promoted degradation of phthalate esters over MnO2: Mineralization enhancement and aquatic toxicity assessment, Chemosphere, 2021,132740. （共同通讯作者）

Xiang Liu*, Wenxin Hou, Xu Meng*, Xiuru Bi, Haiyu Zhao*, Zuo Wang and Didier Astruc*. Degradation of tetracycline over carbon nanosheet: high efficiency, mechanism and biotoxicity assessment. Environmental Science: Nano, 2021. Advance Article （共同通讯作者）

Xiang Liu*, Wenxin Hou, Yu Huang, Haiyu Zhao*, Zan Song and Yingping Huang*, Facile and green synthesis of carbon nanopinnacles for the removal of chlortetracycline: performance, mechanism and biotoxicity. Chemical Engineering Journal. 2022, 431, 133822. （共同通讯作者）

Zihong Kang, Yangyang Bai, Xianyong Lan*, Haiyu Zhao*. Goat AKAP12: Indel Mutation Detection, Association Analysis With Litter Size and Alternative Splicing Variant Expression. Frontiers in Genetics, 2021 https://doi.org/10.3389/fgene.2021.648256. （共同通讯作者）

Jianing Zhao#, Jie Li#, Fugui Jiang, Enliang Song, Xianyong Lan*, Haiyu Zhao*. Fertility-Associated Polymorphism within Bovine ITGβ5 and Its Significant Correlations with Ovarian and Luteal Traits. Animals. 2021; 11(6):1579. https://doi.org/10.3390/ani11061579. （共同通讯作者）

Christian Pylatiuk*, Haiyu Zhao, Eduard Gursky, Markus Reischl, Ravindra Peravali, Nicholas S. Foulkes, Felix Loosli*, DIY Automated Feeding and Motion Recording System for the Analysis of Fish Behavior, SLAS Technology, 2019, 24(4): 394-398.

Sihuan Zhang#, Haiyu Zhao#, Chuzhao Lei, Chuanying Pan, Hong Chen, Qing Lin & Xianyong Lan*. Effects of genetic variations within goat PITX2 gene on growth traits and mRNA expression. Anim Biotechnol. 2020 Apr;31(2):107-114.

Haiyu Zhao#; Sihuan Zhang#; Xianfeng Wu; Chuanying Pan; Xiangchen Li; Chuzhao Lei; Hong Chen; Xianyong Lan^*, DNA methylation pattern of the goat PITX1 gene and its effects on milk performance, Archives Animal Breeding, 2019. 2.20, 62(1): 59~68.

Haiyu Zhao; Xianfeng Wu; Hanfang Cai; Chuanying Pan; Chuzhao Lei; Hong Chen; Xianyong Lan^*, Genetic variants and effects on milk traits of the caprine paired-like homeodomain transcription factor 2 (PITX2) gene in dairy goats , Gene, 2013.12.15, 532(2): 203~210.

Xianyong Lan#, Haiyu Zhao#, Zhuanjian Li, Rui Zhou, Chuanying Pan, Chuzhao Lei, Hong Chen*. Exploring the novel genetic variant of PITX1 gene and its effect on milk performance in dairy goats. Journal of Integrative Agriculture. 2013, 12(1): 118-126. （被评为2017年中国科技期刊“农林学科”年度优秀论文”二等奖）

Xianyong Lan#; Haiyu Zhao#; Chongyang Wu; Shenrong Hu; Chuanying Pan; Chuzhao Lei; Hong Chen, Analysis of genetic variability at codon 42 within caprine prion protein gene in relation to production traits in Chinese domestic breeds, Molecular Biology Reports, 2012.04, 39(4): 4981~4988.

Xianyong Lan#; Haiyu Zhao#; Zhuanjian Li; Aimin Li; Chuzhao Lei; Hong Chen; Chuanying Pan, A novel 28-bp insertion-deletion polymorphism within goat PRNP gene and its association with production traits in Chinese native breeds , Genome, 2012.07, 55(7): 547~552.

授权国家专利：蓝贤勇; 赵海谕; 潘传英; 姜兴武; 陈宏; 雷初朝, 一种奶山羊PITX2基因单核苷酸多态性的检测方法及其应用 , 2014.04.09-2032.05.17, 中国, ZL201210153944.3.

学术交流活动：

2018.03   德国 卡尔斯鲁厄 BioInterfaces in Technology and Medicine (BIFTM) Seminar. 会议口头报告：Are females smarter than males? --Feeding and associative learning of fish model.

2017.09   意大利 比萨 第十七次欧洲光生物学年会会议 17th Congress of European Society of Photobiology. 口头报告 "Light-driven DNA repair: lessons from fish". Supported by BIF graduate school.

2017.01   德国 卡尔斯鲁厄 BioInterfaces in Technology and Medicine (BIFTM) Seminar. 会议口头报告 “Light-driven DNA repair systems”

2013.10   中国 成都 第17次全国动物遗传育种学术讨论会. 分会场口头报告“奶山羊PITX1、PITX2 基因SNP、mRNA表达及甲基化修饰对泌乳性能的影响”

2012.07-2012.11  美国 威斯康星大学麦迪逊校区 动物科学系(Animal Science)交流学习 导师：Prof. Dr. Hasan Khatib.