1）先后主持国家自然基金面上项目三项（部分已结题）；

2）主持中央高校基本科研基金三项，作为课题负责人执行中央高校重点项目一项（部分已结题）；

3)  2022年起主持中央高校“学科交叉创新团队建设项目”，生物力学与精准医疗；

4)  国际合作项目等。

硕士及博士招生专业方向：细胞生物学 【1.干细胞及癌细胞表观遗传学；2.医学与肿瘤细胞生物学】（有意报考本团队的硕士生、博士生候选人可直接联系导师; 硕博连读者优先考虑）

几点期望和要求：对从事本专业科研工作有浓厚兴趣、学习能力和动手能力强、心里素质好，能够承受科研工作遇到的失败和挫折，积极向上、有责任心、有团队合作精神； 英语基础较好 （通过6级考试或其他同等水平英语考试者为佳）

现有团队: 讲师1名，博士生5名，硕士生5名，本科生创新创业项目团队多项

指导毕业的研究生：已指导毕业约二十名研究生，其中有多人转博，其余在国内高校科研院所、生物公司、制药企业等处继续从事生物医学相关的科研、教学及产品研发工作。

教学： 主讲本科课程：《表观遗传学》，《兰大导读》，《生命科学前沿讲座》；主讲研究生课程《表观遗传学前沿》，《生物专业英语》（曾主讲）

在研方向：

1. 以小鼠胚胎干细胞和其他人类及小鼠细胞系为模型研究表观遗传因子对发育相关基因的调控方式和调控机理

2. 真核基因转录调控及相关逆境适应机理

3. 多种类型癌症的发生和发展的表观遗传机制

4. 内源性反转录病毒的表观遗传调控机制

代表论文：

1.      Overcoming cytoplasmic retention of GDOWN1 modulates global transcription and facilitates adaptation to cellular stresses. Zhu Z, Liu J, Feng H, Zhang Y, Huang R, Pan Q, Nan J, Miao R, Cheng B*. eLife, 2022, 11:e79116. doi: 10.7554/eLife.79116.

2.      Mutant p53 in cancer: from molecular mechanism to therapeutic modulation. Chen X, Zhang T, Su W, Dou Z, Zhao D, Jin X, Lei H, Wang J, Xie X, Cheng B, Li Q, Zhang H, and Di C*. Cell Death & Disease, 2022, 13(11):974. doi: 10.1038/s41419-022-05408-1.

3.      Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9. Zhang Y^#, He F^#, Zhang YN^#, Dai Q, Li Q, Nan J, Miao R, Cheng B*. Mobile DNA, 2022, 13:25. doi: 10.1186/s13100-022-00279-x.

4.      Evidence for the involvement of AtPiezo in mechanical responses. Fang X, Zhang Y, Cheng B, Luan S and He K*. Plant Signaling & Behavior, 2021, 16(5):1889252. doi: 10.1080/15592324.2021.1889252.

5.      RNA polymerase II associated proteins regulate stomatal development through direct interaction with stomatal transcription factors in Arabidopsis thaliana. Chen L, Zhao M, Wu Z, Chen S, Rojo E, Luo J, Li P, Zhao L, Chen Y, Deng J, Cheng B, He K, Gou X, Li J and Hou S*. New Phytologist, 2021, 230(1):171-189. doi:10.1111/nph.17004.

6.      A TAT peptide-based ratiometric two-photon fluorescent probe for detecting biothiols and sequentially distinguishing GSH in mitochondria. Su P, Zhu Z, Liang L, Wu W, Cao J*, Cheng B*, Liu W, Tang Y*. Talanta, 2020, 218, 121127. doi:10.1016/j.talanta.2020.121127.

7.      A Smart Tumor-microenvironment Responsive Nanoprobe for Highly Selective and Efficient Combination Therapy. Fan Y, Guan S, Fang W, Li P, Hu B, Shan C, Wu W, Cao J*, Cheng B*, Liu W and Tang Y*. Inorganic Chemistry Frontiers, 2019, 6, 3562-3568. doi:10.1039/c9qi01076a.

8.      Smart MMP2-Responsive Nanoprobe for Activatable Fluorescence Imaging-Guided Local Triple-Combination Therapies with Single Light. Hu B, Li P, Yang X, Fan Y, Shan C, Su P, Cao J, Cheng B*, Liu W*, Tang Y*. ACS Appl. Bio Mater., 2019, 2(7):2978-2987. doi:10.1021/acsabm.9b00321.

9.      A Smart Photosensitizer–Cerium Oxide Nanoprobe for Highly Selective and Efficient Photodynamic Therapy. Fan Y, Li P, Hu B, Liu T, Huang Z, Shan C, Cao J*, Cheng B*, Liu W, Tang Y*. Inorganic Chemistry. 2019, 58(11):7295-7302. doi:10.1021/acs.inorgchem.9b00363.

10.    PRC1.6复合体决定生殖谱系特异性基因的时空表达.孙晓伟^#,李宏阳^#,王健,程博*.遗传, HEREDITAS, 2019, 41(4):271-284. (受邀撰稿，封面故事) doi:10.16288/j.yczz.18-332.

11.    Activatable Smart Nanoprobe for Sensitive Endogenous MMP2 Detection and Fluorescence Imaging Guided Phototherapies. Hu B^#, Li P^#, Zhang Y, Shan C, Su P, Cao J*, Cheng B*, Wu W, Liu W, Tang Y*. Inorganic Chemistry Frontiers, 2019, 6:820-828. doi:10.1039/c9qi00002j. 

12.    Surface Ligand Coordination Induced Self-assembly of Nanohybrid for Efficient Photodynamic Therapy and Imaging. Su P, Zhu Z, Fan Q, Cao J*, Wang Y, Yang X, Cheng B*, Liu W, Tang Y*. Inorganic Chemistry Frontiers, 2018, 5:2620-2629. doi:10.1039/C8QI00777B.

13.    A biomolecule-based fluorescence chemosensor for sequential detection of Ag+ and H2S in 100% aqueous solution and living cells. Su P, Zhu Z, Wang J, Cheng B*, Wu W, Iqbal K, Tang Y*. Sensors & Actuators: B. Chemical, 2018, 273: 93-100. doi:10.1016/j.snb.2018.06.037. 

14.    Functionalized Eu(III)-Based Nanoscale Metal-Organic Framework To Achieve Near-IR-Triggered and -Targeted Two-Photon Absorption Photodynamic Therapy. Jia J, Zhang Y, Zheng M, Shan C, Yan H, Wu W, Gao X, Cheng B*, Liu W, Tang Y*. Inorganic Chemistry, 2018, 57 (1):300-310. doi:10.1021/acs.inorgchem.7b02475. 

15.    Structural and functional diversity of mammalian CBX proteins (in Chinese). 关珊丽，王健，谢忆，程博*. (受邀撰稿) 中国科学, Sci Sin Vitae, 2017, 47(8):847-862. doi:10.1360/N052017-00012.

16.    KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. Cheng B^#, Ren X^#, and Kerppola TK*. Molecular and Cellular Biology, 2014, 34(11):2075- 91. doi:10.1128/MCB.01729-13.

17.    Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins. Ma R^#, Zhang Y^#, Sun T^#, Cheng B*. (受邀撰稿) 浙大学报,Journal of Zhejiang University-Science B, 2014, 15(5):412-28. doi:10.1631/jzus.B1400077.

18.    Functional association of Gdown1 with RNA polymerase II poised on human genes. Cheng B^#, Li T^#, Rahl PB, Adamson TE, Loudas NB, Guo J, Varzavand K, Cooper JJ, Hu X, Gnatt A, Young RA, Price DH*. (封面故事并同期发表评论文章) Molecular Cell, 2012, 45(1): 38-50. doi:10.1016/j.molcel.2011. 10.022. 

19.    Isolation and functional analysis of RNA polymerase II elongation complexes. Cheng B, Price DH*. (受邀撰稿) Methods, 2009, 48(4):346-52. doi:10.1016/j.ymeth.2009.02.026. 

20.    Analysis of factor interactions with RNA polymerase II elongation complexes using a new electrophoretic mobility shift assay. Cheng B, Price DH*. Nucleic Acids Research, 2008, 36(20):e135. doi:10.1093/nar/gkn630. 

21.    Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. Cheng B, Price DH*. Journal of Biological Chemistry, 2007, 282(30):21901-12. doi:10.1074 /jbc.M702936200.