董守良
个人简历
科研成果
教学情况
研究方向
荣誉奖励
论文专著
其他信息
个人简历
基本信息
职称:教授
办公室地址:: 逸夫生物楼1210,实验室1201
邮箱:dongsl@lzu.edu.cn
学习经历
1991.9-1995.6,兰州大学生物系,本科;
1995.9-1998.6,兰州大学生命科学学院,硕士;
1998.9-2001.6,兰州大学生命科学学院,博士;
工作经历
2001.7-2004.5,兰州大学生命科学学院,讲师;
其中2003.11-2004.11,德国马克斯-普朗克生物化学研究所,博士后;
2004.5-2012.4,兰州大学生命科学学院,副教授;
其中2007.3-2008.9,德国马克斯-普朗克生物化学研究所,客座学者;
2012.5-今,兰州大学生命科学学院,教授;博士生导师;
社会工作
1. 中国生理学学会会员
2. 甘肃省免疫学会流式细胞技术专委会副主任委员
3. 甘肃省生理学会理事
科研成果
2. 甘肃省自然科学基金青年/面上基金;
3. 教育部留学归国人员启动基金;
4. 企业协作科研项目多项;
教学情况
本科生教学:
系统讲授《动物生理学》、《动物生理学实验》和《计算机辅助药物设计》。
研究生教学:
系统讲授《计算机辅助药物设计》,负责《多肽研究进展》课程。
指导研究生情况:
在校人员
姓名 Email 职务 籍贯
2024级
杨童 yangt2024[a]lzu.edu.cn 博士生 甘肃
余晨曦 yuchx2024[a]lzu.edu.cn 硕士生 陕西
鲍慧明 baohm2024[a]lzu.edu.cn 硕士生 安徽
2023级
Jerine Peter S. peterjerine[a]gmail.com 博士后 印度
张忠华 zhzhonghua2023[a]lzu.edu.cn 博士生 四川
黄明敏 huangmm20230[a]lzu.edu.cn 硕士生 四川
郭昶志 guochzh2023[a]lzu.edu.cn 硕士生 内蒙古
2022级
牛占宇 120220906890[a]lzu.edu.cn 博士生 山西
蔄弘扬 120220906881[a]lzu.edu.cn 博士生 辽宁
李鹏涛 220220932881[a]lzu.edu.cn 硕士生 甘肃
2021级
王 岚 wanglan2021[a]lzu.edu.cn 博士生 河北
2020级
王 豪 wangh20[a]lzu.edu.cn 博士生 河南
周 军 zhouj@ 博士生 湖北
2019级
赵耀峰 zhaoyf16[a]lzu.edu.cn 博士生 甘肃
研究方向
使用非天然氨基酸或者化学键代替原始氨基酸或者肽键,设计并合成新型生物活性多肽,使之具备比母体更好的活性和持久的药物时间。
荣誉奖项
1. 甘肃省教学创新大赛二等奖 (2024, 1/4)
2. 指导研究生参加第四届“中国研究生乡村振兴科技强农+创新大赛”自然科学类二等奖(2024)
3. 指导本科生参加第九届全国大学生生物科学竞赛获科学探究类甘肃省三等奖(2024)
4. 国家级一流课程 (2023, 1/4)
5. 兰州大学教学成果二等奖(2023,1、5)
6. 兰州大学第四届教师教学创新大赛正高组二等奖(2023)
7. 兰州大学隆基教学骨干奖(2023)
8. 指导本科生参加第八届全国大学生生物科学竞赛获科学探究类国赛一等奖(2023)
9. 指导本科生参加第八届全国大学生生物科学竞赛获科学探究类甘肃省一等奖(2023)
10. 甘肃省省级一流课程 (2022, 2/4)
11. 甘肃省省级一流课程 (2020, 1/4)
12. 甘肃省省级教学团队 (2020, 2/5)
13. 指导本科生参加第五届全国大学生生物科学竞赛获科学探究类甘肃省三等奖(2020)
14. 甘肃省虚拟仿真一流课程(2019,1/4)
15. 甘肃医学科学奖二等奖(2019,5/7)
16. 甘肃省科技进步二等奖(2014,3/7)
17. 甘肃省精品课程(2011)
18. 兰州大学隆基青年教师新秀奖(2010)
19. 德国克虏伯基金会中国青年学者奖(2003)
20. 甘肃省精品课程(2003,3/3)
21. 教育部理科基地名牌课程(2002,2/3)
22. 指导本科生参加甘肃省挑战杯获一等奖(2002)
23. 神经肽类似物的设计合成、溶液构象和生物活性,教育部科技成果鉴定(2001, 第三完成人)
24. 甘肃省科技进步三等奖(2001,2/10)
论文专著
2024
97. 贺春波,王丹,杨淑佳,周开文,邓怡平,董守良. 新型阿片类镇痛药的研发进展. 中国药房, 2024, 35(17): 2176-2180. DOI: 10.6039/j.issn.1001-0408.2024.17.21
96. Yaofeng Zhao, Zhonghua Zhang, Dingnian Gou, Pengtao Li, Tong Yang, Zhanyu Niu, Jerine Peter Simon, Xuyan Guan, Xinyu Li, Chunbo He, Shouliang Dong*. Intrathecal administration of MCRT produced potent antinociception in chronic inflammatory pain models via μ-δ heterodimer with limited side effects. Biomedicine & Pharmacotherapy, 2024, 179, 117389. DOI: 10.1016/j.biopha.2024.117389
95. Zhengkun Liu*, Pengtao Li, Qianqian Wang,Shouliang Dong**. "Double-locked" fluorescent probe based on a push-pull structure for detecting HClO/H2O2. Tetrahedron, 2024, 164, 134163. DOI: 10.1016/j.tet.2024.134163
94. Jerine Peter Simon and Shouliang Dong*. In-silico screening of missense nsSNPs in Delta-opioid receptor protein and their restoring tendency on MCRT interaction; focusing on dynamic nature. International Journal of Biological Macromolecules. 2024, 275, 133710. DOI: 10.1016/j.ijbiomac.2024.133710
93. Chenxi Mei, Jing Zhang, Zhanyu Niu, Jerine Peter Simon, Tong Yang, Mingmin Huang, Zhonghua Zhang, Lanxia Zhou, Shouliang Dong*, MP-13, a novel chimeric peptide of morphiceptin and pepcan-9, produces potent antinociception with limited side effects. Neuropeptides. 2024, 107, 102440. DOI: 10.1016/j.npep.2024.102440
92. 董守良, 赵耀峰. 一种一体化数据可追踪小鼠大鼠两用辐射热甩尾测痛仪. 实用新型专利, 2024,ZL202321571908.9
2023
91. 董守良, 贺春波, 王豪, 赵耀峰, 王小丽, 苏文婷. 一类作用于多靶点的长效镇痛肽类化合物的制备及应用. 国家发明专利, 2023,ZL202010943836.0.
2022
90. Shasha Chen, Dingnian Gou, Zhengkun Liu, Zhonghua Zhang, Lanxia Zhou, Shouliang Dong∗. Gram-scale Preparation of DAMGO by Typical Solid Phase Synthesis. Tetrahedron Letters. 2022, 112, 154239. https://doi.org/10.1016/j.tetlet.2022.154239.
89. Zhengkun Liu, Shasha Chen, Hao Wang, Yaofeng Zhao, Shouliang Dong*. Thiol-Michael addition based conjugate for glutathione activation and release. Bioorganic Chemistry. 2022, 129, 106221. https://doi.org/10.1016/j.bioorg.2022.106221
88. 董守良, 马明,唐晓龙,常民. 兰州大学生物科学专业实验课程教学改革与实践——以动物生理学实验为例. 高校生物学教学研究(电子版), 2022, 12(4), 29-33.
87. 董守良, 马明,唐晓龙,常民.动物福利原则下的混合式生理学实验教学改革. 基础医学教育,2022, 24(7), 504-507.
2021
86. Chunbo He, Xiaoli Wang, Jing Zhang, Hao Wang, Yaofeng Zhao, Jagat Narayan Shah, Chan Ma, Hailan Li, Wenting Su, Zhe Zhang, Shasha Chen, Lanxia Zhou*, Shouliang Dong*. MCRT, a Multifunctional Ligand of Opioid and NPFF Receptors, Attenuates Neuropathic Pain in Spared Nerve Injury Model. Basic & Clinical Pharmacology & Toxicology. 2021,128(6): 731-740. DOI: 10.1111/bcpt.13566.
85. 马明, 唐晓龙, 常民, 董守良, 陈强. 动物生理学实验MOOC/SPOC的建设与实践. 实验室科学, 2021, 24(02): 166-170.
2020
84. Lanxia Zhou, Hong Guo, Fang Jia, Xuan Chen, Xiaowei Zhang, Shouliang Dong*, Li Zhao*. Studies on the changes of uPA system in a co-culture model of bone marrow stromal cells–leukemia cells. Bioscience Reports. 2020, 40(11), BSR20194044. DOI: 10.1042/BSR20194044
83. Jing Zhang, Chan Ma, Ruijia Wang, Chunbo He, Hailan Li, Shouliang Dong*. Endokinin A/B stimulates rat gastric motility through myogenic NK1 receptors located in fundus. Can. J. Physiol. Pharmacol. 2020, 98: 691-699. DOI: 10.1139/cjpp-2019-0522.
82. 实验课程中应用MOOC/SPOC的教学模式探索——以动物生理学实验为例. 马明,唐晓龙,常民,董守良,陈强. 实验室研究与探索. 2020, 06, 166-168+206
81. Zhengkun Liu, Qianqian Wang, Mohui Li, Yujie Ai, Haoxuan Pan, Pengtao Li, Hao Lang, Kunyu Li, Shouliang Dong*. White light emission from single natural molecules: solvatochromic properties of 10-hydroxycamptothecin. Dyes and Pigments. 2020, 180, 108533. DOI: 10.1016/j.dyepig.2020.108533
80. Zhengkun Liu, Qianqian Wang, Hao Wang, Wenting Su, Shouliang Dong*. A FRET Based Two-Photon Fluorescent Probe for Visualizing Mitochondrial Thiols of Living Cells and Tissues. Sensors 2020, 20(6), 1746; https://doi.org/10.3390/s20061746.
79. Zhengkun Liu, Qianqian Wang, Hao Wang, Yuheng Lan, Shouliang Dong*. Quaternary ammonium modified fluorescent probe for hydrogen sulfide detection in living cells. Journal of Photochemistry & Photobiology, A: Chemistry. 2020, 389, 112213. http://doi.org/10.1016/j.jphotochem.2019.112213.
2019
78. Zhengkun Liu, Qianqian Wang, Hao Wang, Wenting Su, Shouliang Dong*. A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems. Tetrahedron Letters. 2019, 60(44), 151218. http://doi.org/10.1016/j.tetlet.2019.151218.
77. 马明, 唐晓龙, 常民, 董守良, 陈强. 浅谈如何提高蛙心灌流实验的教学效果. 实验室科学, 2019, 22(01): 72-75.
76. Chunbo He, Hailan Li, Jing Zhang, Lanxia Zhou⁎, Shouliang Dong⁎⁎. In vitro and in vivo characterization of the bifunctional μ- and δ-opioid receptors ligand MCRT on mouse gastrointestinal motility. Neuropeptides, 2019, 74: 82-87. DOI: 10.1016/j.npep.2019.01.006.
2018
75. 马明,常民,唐晓龙,董守良,陈强. 动物生理学实验调查问卷分析. 实验室科学. 2018, 21(3): 208-212.
2017
74. Xiangdong Cai, Zhao Liu, Sha Zhao, Chen Song, Shouliang Dong* and Jianxi Xiao*. A single stranded fluorescent peptide probe for targeting collagen in connective tissues. ChemComm. 2017.53: 11905-11908. DOI: 10.1039/c7cc06056d.
73. 马明,唐晓龙,董守良,常民,陈强. 动物生理学实验课程的定位与改革实践. 实验室科学. 2017, 20(3): 84-87.
72. 马明,盛英卓,董守良,常民,唐晓龙,陈强. 一种输液针改造的多用途家兔插管. 实用新型专利,已授权(授权日:2017/10/13):ZL201621274454.9
71. 董守良,玄其存,曹硕,常民. 一种布舍瑞林的固液合成方法. 国家发明专利, 已授权(授权日:2017/09/27): ZL201410741975.X.
70. Xu Li,Zhengkun Liu and Shouliang Dong*. Bicyclo[6.1.0]nonyne and tetrazine amino acids for Diels-Alder Reactions. RSC Advances. 2017, 7, 44470-44473. DOI: 10.19/c7ra08136g.
69. Chunbo He, Hailan Li, Jing Zhang, Yanping Kang, Fang Jia, Shouliang Dong*, Lanxia Zhou*. Supraspinal Inhibitory Effects of Chimeric Peptide MCRT on Gastrointestinal Motility in Mice. Journal of Pharmacy and Pharmacology. 2017, 69, 1244-1251. doi: 10.1111/jphp.12761.
68. 董守良, 曹硕, 李兆亮, 葛鑫. 一种地加瑞克的固相合成方法. 国家发明专利, 已授权(授权日期:2017/02/21): ZL201410211655.3.
2016
67. Jing Zhang, Chunbo He, Xiong Pi, Yan Wang, Lanxia Zhou*, Shouliang Dong*. MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B. European Journal of Pharmacology. 2016, 792, 33-37. DOI: 10.1016/j.ejphar.2016.10.028.
66. S. Cao, Q. Jin, L.Geng, L. Mu and S. Dong*, A “turn-on” fluorescent probe for detection of Cu2+ in living cells based on signaling mechanism of N=N isomerization. New J. Chem., 2016, 40, 6264 - 6269. DOI: 10.1039/C5NJ03649F.
65. Chunbo He, Junbin Gong, Lixia Yang, Hongwei Zhang, Shouliang Dong*,Lanxia Zhou*. The pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice. Canadian Journal of Physiology and Pharmacology. 2016, 94: 955–960. DOI: 10.1139/cjpp-2015-0554.
2015
64. Zhongqiu Ni, Lanxia Zhou, Xu Li, Jing Zhang, Shouliang Dong*. Tetrazine-Containing Amino Acid for Peptide Modification and Live Cell Labeling. PLOS One, 2015, 10(11): e0141918. Doi: 10.1371/journal.pone.0141918.
63. Lanxia Zhou⁎, Qing Yang, Chunbo He, Chunnan Wei, Yinliang Yang, Shouliang Dong⁎⁎. Interaction of endokinin A/B and (Mpa6)-γ2-MSH-6–12 in pain regulation in mice, Neuropeptides 2015,53, 79-84 DOI: 10.1016/j.npep.2015.06.007.
2014
62.周兰霞,董守良,倪中秋. 一种化合物L-4-四嗪-苯丙氨酸及其制备方法和应用, 国家发明专利, 已授权: ZL201210080698.3
2013
61. 周兰霞,达文平, 姚佳,杨银亮,董守良, 赵丽. Opiorphin溶液构象分析. 兰州大学学报( 医学版). 2013. 39(3): 14-17.
60. Jianbing Jiang, Longfei Yang, Qiaoying Jin, Wude Ma, Luis Moroder, Shouliang Dong*. Site-Directed Spin Labeling of a Collagen Mimetic Peptide. Chem. Eur. J. 2013, 19, 17679-17682. DOI: 10.1002/chem.201303290.
59. 董守良,刘正锟,李晓莉,抗肿瘤药物罗米迪司肽的关键中间体的合成方法,国家发明专利,已授权。专利号:ZL201110123735X.
58. 董守良,李梅兴. 一种齐考诺肽的固相合成方法,国家发明专利,已授权。专利号:ZL201110139661.9.
57. Meixing Li, Lanxia Zhou, Guoning Ma, Shuo Cao, Shouliang Dong*. The cardiovascular effects of a chimeric opioid peptide based on morphiceptin and PFRTic-NH2. Peptides, 2013,39(1):89-94. Doi: 10.1016/j.peptides.2012.10.014.
2012
56. Meixing Li, Lanxia Zhou, Guoning Ma, Shouliang Dong*. Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide. Regulatory Peptides. 2012, 179, 23-28. DOI: 10.1016/j.regpep.2012.08.008.
55. Lanxia Zhou, Qiaoying Jin, Yinliang Yang, Zhengkun Liu, Xiaoli Li, Shouliang Dong*, Li Zhao**. Effects of Endokinin A/B and Endokinin C/D on the antinociception of properties of hemopressin in mice. Peptides.2012,38: 70-80. DOI: 10.1016/j.peptides.2012.08.006.
54. 陈强, 董守良, 常民. 兰州大学生物科学专业动物生理学精品课程的建设. 中国生理学会第十届全国生理学教学研讨会论文摘要汇编, 2012. 中国生理学会第十届全国生理学教学研讨会. 2012-05-11, 中国江西南昌.
2011
53. Qiaoying Jin, Li Lu, Yinliang Yang, Shouliang Dong*. Effects of Endokinin A/B, Endokinin C/D, and Endomorphin-1 on the regulation of mean arterial blood pressure in rats. Peptides. 32 (2011) 2428–2435. Doi: 10.1016/j.peptides.2011.10.017.
52. Bo Zhang, Junbin Gong, Yinliang Yang, Shouliang Dong*. Synthesis and diuretic activities of pseudoproline-containing analogues of the insect kinin core pentapeptide. J. Pept. Sci. 2011; 17: 601–603. DOI: 10.1002/psc.1396.
51. Wenwei Zhang, Yuling Zeng, Shasha Wang, Qing Yang, Shouliang Dong*. Conformation analysis of a bradykinin B2 receptor antagonist, a proline rich undecapeptide. Acta Biophysica Sinica. 27(11): 937-940. DOI: 10.3724/SP.J.1260.2011.00937.
50. Long-Fei Yang, Yang Xiao, Yun Huang, Guo-Ning Ma, Zhi-Yuan Cong and Shou-Liang Dong*. In vitro characterization for the effects of insect kinins on mouse distal colonic motility. In "Peptides: Chemistry, Biology and Pharmaceutical Sciences", Ed. by Rui Wang and Kai-Rong Wang, Proceedings of the 11th Chinese International Peptide Symposium, July 5-8, 2010, Lanzhou, China. July, 2010, 199-203.
49. Tobias E. Schrader,Thorben Cordes,Wolfgang J. Schreier,Florian O. Koller, Shou-Liang Dong, Luis Moroder, Wolfgang Zinth. Folding and Unfolding of Light-Triggered β-Hairpin Model Peptides. J. Phys. Chem. B. 2011, 115, 5219–5226. DOI: 10.1021/jp107683d.
48. Jing Wang, Li Wang, Meixing Li, Qiaoying Jin, Shouliang Dong*. Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides. Peptides. 2011, 32; 1055–1059. doi:10.1016/j.peptides.2011.01.032.
2010
47. ChunnanWei, Wenmin Huang, Xiaoting Xing and Shouliang Dong*. Dual effects of [Tyr6]-γ2-MSH(6–12) on pain perception and in vivo hyperalgesic activity of its analogues. J. Pept. Sci. 2010,16, 451-455. DOI: 10.1002/psc.1255.
46. Sha-Sha Wang, Yu-Ling Zeng, Wen-Wei Zhang, Shou-Liang Dong*. A snake venom peptidewith the contrary effect on rat stomachfundus and guinea pig ileum. Pharmazie.,2010,65: 383–385. doi: 10.1691/ph.2010.9683.
45. Yinliang Yang, Zhongqiu Ni, Shouliang Dong*, Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice. Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice. Peptides, 2010,31(4): 689-695. doi:10.1016/j.peptides.2009.12.022.
44. Zhiyuan Cong, Yun Huang, Longfei Yang, Dan Ye, Shouliang Dong*, Solution structure of a photo-switchable insect kinin thioxo-analog. Protein & Peptide Letters. 2010,17(3): 343-346.
43. 魁红,罗会颖,董守良,姚斌. 一种来源于Bispora betufina的酸性木聚糖酶基因克隆及其酶学性质研究. 中国农业科技导报,2010,12(5):109—1 15.
42. 张 波, 丛志远, 杨银亮, 杨龙飞, 董守良*. 昆虫激肽的生理功能及机制. 生命的化学.,2010,30(1): 42-45.
41. Zhiyuan Cong, Longfei Yang, Ling Jiang, Dan Ye, Shouliang Dong*. Comparison of two thioxopeptide bond photoswitches in insect kinin. Chinese Chemical Letters. 2010,21(4): 476-479. doi:10.1016/j.cclet.2009.12.033.
40. Hong Kui, Huiying Luo, Pengjun Shi, Yingguo Bai, Tiezheng Yuan, Yaru Wang, Peilong Yang, Shouliang Dong, Bin Yao. Gene Cloning, Expression, and Characterization of a Thermostable Xylanase from Nesterenkonia xinjiangensis CCTCC AA001025. Appl Biochem Biotechnol. 2010,162(4):953-65. DOI: 10.1007/s12010-009-8815-5.
39. Yinliang Yang, Shouliang Dong*. Effects of Endokinin A/B and Endokinin C/D on the modulation of pain in mice. Peptides. 2010,31(1), 94-100. doi:10.1016/j.peptides.2009.10.013.
38. Guohua Lv, Shouliang Dong*. Solution Structural Investigation and Conformation-Activity Relationship of BAM8-22 by NMR and Molecular Dynamics Simulations. Bioorganic & Medicinal Chemistry Letters. 2010,20(3), 1260-1262. doi: 10.1016/j.bmcl.2009.11.110.
2009
37. Shouliang Dong, Luis Moroder, Nediljko Budisa. Protein Iodination by Click Chemistry. ChemBioChem, 2009,10, 1149-1151. DOI: 10.1002/cbic.200800816.
36. 马国宁, 董守良*. 阿片肽样嵌合肽. 生命的化学. 2009,29(3), 414-417.
2008
35. Huang, Y., Cong, Z., Yang, L., and Dong, S*. A photoswitchable thioxopeptide bond facilitates the conformation-activity correlation study of insect kinin, J Pept Sci 2008,14, 1062-1068.
34. Dong, S., Merkel, L., Moroder, L., and Budisa, N. Convenient syntheses of homopropargylglycine, J Pept Sci 2008, 14, 1148-1150.
33. Li Zhao, Lanxia Zhou, Baohong Zhang, Xiang Yan, Juan Li, Yali Peng, Min Chang, Shouliang Dong, Rui Wang, Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell, Pharmazie, 2008,63: 676-685.
32. Dong, S.L., Merkel, L., Musiol, H.J., Budisa, N. and Moroder, L. (2008). Advances in the stereoselective synthesis of homopropargylglycine. J. Peptide Sci. 2008,14 (8), 49-49.
31. 金莲,刘鑫,王锐,董守良*,神经介素B 受体与拮抗剂、激动剂的分子模拟研究,化学学报,2008,2271-2278.
30. 杨丹,董守良*,人体激肽释放酶2与前列腺癌,生命的化学,2008,731-736.
2007
29. Zinth, W., Schrader, T. E., Schreier, W. J., Koller, F. O., Cordes, T., Babitzki, G., Denschlag, R., Tavan, P., Loweneck, M., Dong, S. L., Moroder, L., and Renner, C. Ultrafast unzipping of a beta-hairpin peptide, Ultrafast Phenomena Xv 2007,88, 498-500.
28. Yu, Y., Shao, X., Cui, Y., Liu, H., Wang, C., Fan, Y., Liu, J., Dong, S., and Wang, R. Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus, Chemmedchem 2007,2, 309-317.
27. Schrader, T. E., Schreier, W. J., Cordes, T., Koller, F. O., Babitzki, G., Denschlag, R., Renner, C., Loweneckt, M., Dong, S. L., Moroder, L., Tavan, P., and Zinth, W. Light-triggered beta-hairpin folding and unfolding, Proceedings of the National Academy of Sciences of the United States of America 2007,104, 15729-15734.
26. Dong, S. L., Cadamuro, S. A., Fiorino, F., Bertsch, U., Moroder, L., and Renner, C. Copper binding and conformation of the N-terminal octarepeats of the prion protein in the presence of DPC micelles as membrane mimetic, Biopolymers 2007,88, 840-847.
25. 周兰霞,金莲,赵丽,孟雪琴,董守良*,ArcGIS910在苯丙酮尿症空间分析中的应用,中国卫生统计,2007,24,604-606.
2006
24. Peng, Y. L., Chang, M., Dong, S. L., Li, W., Han, R. W., Fu, G. X., Chen, Q., and Wang, R. Novel potent agonist (pF)Phe(4),Aib(7) Aib(11),Arg(14),Lys(15) N/OFQ-NH2 and antagonist Nphe(1),(pF)Phe(4),Aib(7),Aib(11),Arg(14),Lys(15) N/OFQ-NH2 Of nociceptin/orphanin FQ receptor, Regulatory Peptides 2006,134, 75-81.
23. Loeweneck, M., Dong, S.-L., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photo-controlled beta-hairpin, Understanding Biology Using Peptides, 2006,36-37.
22. Dong, S. L., Loweneck, M., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photocontrolled beta-hairpin peptide, Chemistry-a European Journal 2006,12, 1114-1120.
2005
21. Musiol, H.-J., Dong, S., Kaiser, M., Bausinger, R., Zumbusch, A., and Moroder, L. Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins, Peptides 2004, Proceedings:BRIDGES BETWEEN DISCIPLINES, 595-596.
20. Musiol, H. J., Dong, S. L., Kaiser, M., Bausinger, R., Zurnbusch, A., Bertsch, U., and Moroder, L. Toward semisynthetic lipoproteins by convergent strategies based on click and Ligation chemistry, Chembiochem 2005,6, 625-628.
19. Musiol, H. J., Dong, S. L., Kaiser, M., Bausinger, R., Zumbusch, A., and Moroder, L. Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins, Peptides 2004, Proceedings, 595-596.
18. Loeweneck, M., Dong, S. L., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photo-controlled beta-hairpin, Biopolymers 2005,80, 547 (abstract).
17. Chang, M., Peng, Y. L., Dong, S. L., Han, R. W., Li, W., Yang, D. J., Chen, Q., and Wang, R. Structure-activity studies on different modifications of nociceptin/orphanin FQ: Identification of highly potent agonists and antagonists of its receptor, Regulatory Peptides 2005,130, 116-122.
16. 刘鑫,董守良*. 胸腺5肽同其受体结合的分子模型. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p86
15. 彭雅丽,常民,李威,韩仁文,付国兴,董守良,王锐. (2005) 孤啡肽N末端修饰类似物的构效关系研究. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p94
14. 常民,彭雅丽,韩仁文,李威,付国兴,董守良,王锐. (2005) 孤啡肽不同修饰的构效关系研究:孤啡肽受体激动剂和拮抗剂的检定. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p145
2004
13. Shouliang Dong, Tao Wang, Bangzhi Zhang, Jie Wei, and Rui Wang. Synthesis and hypotensive activity of [Tyr1]NC(1-13)NH2, an analog of nociceptin. in Peptides, Biology and Chemistry, Eds, Yu-cang Du, You-shang Zhang, James P. Tam (2004). 189-191.
2003
12. Da, C. S., Wei, J., Dong, S. L., Xin, Z. Q., Liu, D. X., Xu, Z. Q., and Wang, R. Highly catalytic enantioselective epoxidation of enones with weak base bicarbonate and hydrogen peroxide, Synthetic Communications 2003,33, 2787-2792.
11. 李仁德,董守良,陈强. (2003) 人体及动物生理学实验指导. 兰州大学出版社.
2002
10. Xin, Z. Q., Da, C. S., Dong, S. L., Liu, D. X., Wei, J., and Wang, R. A novel method for the synthesis of (R)-2,2 '-dihydroxy-1,1 '-binaphthyl-3,3 '-dicarboxylic acid by asymmetric oxidative coupling of a chiral beta-naphthol derivative catalyzed by CuCl, Tetrahedron-Asymmetry 2002,13, 1937-1940.
9. Zheng-Ping Jia, Shou-Liang Dong, Xiao-Wu Yang, Bang-Zhi Zhang Xiao-Li Wang and Rui Wang. (2002) Anticancer pharmacology of actinomycin D and its analogs. In Peptides, Biology and Chemistry. Eds, James P. Tam. P198-201
2000
8. Shou-liang Dong, Rui Wang, Tao Wang and Xiao-yu Hu. The synthesis and opioid activities of nociceptin and its fragments. In Peptides, Biology and Chemistry. Eds, Xiao-yu Hu, Rui Wang, James P. Tam. P95-97
7. Rui Wang, Tao Wang, Shou-Liang Dong, Qiang Chen and Xiao-Yu Hu. Hypotensive activities of nociceptin and its fragments. In Peptides, Biology and Chemistry. Eds, Xiao-yu Hu, Rui Wang, James P. Tam. P108-109
6. 陈强; 陈勇; 陈鲤翔; 杨顶建; 董守良; 王锐; 痛稳素的合成及其对血管活性的影响, 科学通报,2000,45,2620-2625.
1999
5. 董守良,王涛,陈强,王锐. 孤啡肽及其片段的合成和构效关系. 科学通报,1999,44,1296-1300.
4. 董守良, 王 涛, 陈 强, 王 锐. 孤啡肽及其片段的合成、痛觉调节作用和对免疫功能的影响. 药学学报,1999,34,669-672.
3. 董守良,王 涛,王 锐. 孤啡肽研究进展. 中国药理学通报,1999,15,300-303.
1998
2. 董守良,倪京满,王 勤,王 锐. 放线菌素D 及类似物对荷瘤小鼠生理生化影响. 兰州大学学报,1998,34,137-138.
1997
1. WANG R, NI J, HU X, MA Y, LI X, YANG D, DONG S, YANG X, and PAN X. Synthesis and DNA-binding ability of Spl protein zinc finger domain and its peptidomimetics. Science in China, Ser. C, 1997,5, 518-523.
其他信息
已毕业学生:
届 姓 名 去向 (截至离校时)
2024
勾定念 贵州选调生
梅晨曦 出国留学
2023
陈莎莎 四川大学
张静 上海市
张忠华 兰州大学
李若韵 福建省福州市机关
薛宏祥 深圳
2022
刘正锟 陇东学院
张 哲 上海
2021
贺春波 德州学院
苏文婷 国药集团兰州生物制品所
王小丽
2020
刘正锟 兰州大学
马 婵 庆阳市第一中学
兰煜衡 福建盛迪医药有限公司(恒瑞药业子公司)
2019
王倩倩 苑东生物制药(成都)
李海兰 浙江大学
2018
杨丽霞 毕节市第一人民医院
2017
贾 芳 南京圣和药业
康艳萍 四川科伦药业股份有限公司
张 静 兰州大学博士生
2016
耿 琳 北京义翘神州生物技术有限公司
贺春波 兰州大学博士生
2015
李 续 鲁抗辰欣药业股份有限公司
曹 硕 北京双鹤药业研究院
2014
马吾得 深圳市康哲药业有限公司
2013
刘正锟 甘肃中医学院
李晓莉 西安唐都医院
杨 青 武威市
2012
李梅兴 西安市中心医院
金侨英 兰州大学第二医院
宫俊斌 宝鸡市中心血站
姜 玲 北京百世登生物医学科技公司
倪中秋 江苏施美康药业有限公司
2011
江建冰 荷兰莱顿大学博士生
2010
王 晶 甘肃省农科院
魁 红 兰州大学生命科学学院
杨龙飞 西安唐都医院
张紊玮 甘肃农业大学
2009
王 黎 兰大生命科学学院博士生
王莎莎 北京大学
魏春楠 甘肃农业大学
杨银亮 德国莱比锡大学博士生
张 波 北京元森制药有限公司
吕国华 德国马普所博士生
马国宁 兰州中心血站
丛志远 西安军队某所
2008
达文平 甘肃省疾病预防控制中心
黄 云 德国马普所博士生
金 莲 中科院北京计算所
刘 鑫 兰大生命科学学院博士生
肖 杨 北京某军区
杨 丹 成都地奥集团
曾玉玲 北京嘉林药业股份有限公司