本科生课程：《自由基与健康》、《遗传学》

研究生课程：《氧化还原信号传导专题》

现指导2名硕士研究生

研究方向为自由基生物学与医学，主要包括以下几个方面：

1，视网膜细胞和皮肤细胞氧化损伤及其机制

2，活性氧在肿瘤细胞中的作用及其相关信号

3，抗氧化剂治疗相关疾病

4，辐射和微重力联合作用对细胞功能的影响及相关信号通路的调控

SCI论文：

1. Zhu S, Li X, Wu F, Cao X, Gou K, Wang C, Lin C*. Blue light induces skin apoptosis and degeneration through activation of the endoplasmic reticulum stress-autophagy apoptosis axis: Protective role of hydrogen sulfide. J Photochem Photobiol B. 2022 Apr; 229:112426. （通讯作者）

2. Zhu S, Li X, Dang B, Wu F, Wang C, Lin C*. Lycium Barbarum polysaccharide protects HaCaT cells from PM2.5-induced apoptosis via inhibiting oxidative stress, ER stress and autophagy. Redox Rep. 2022 Dec;27(1):32-44. （通讯作者）

3. Zhu S, Li X, Dang B, Wu F, Gou K, Wang C, Lin C*. Hydrogen sulfide protects retina from blue light-induced photodamage and degeneration via inhibiting ROS-mediated ER stress-CHOP apoptosis signal. Redox Rep. 2022 Dec;27(1):100-110. （通讯作者）

4. Hu L#, Guo J#, Zhou L, Zhu S, Wang C, Liu J, Hu S, Yang M, Lin C*. Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Apoptosis and Affects Autophagy. Oxid Med Cell Longev. 2020 Dec 30;2020:8868564.（通讯作者）

5. Wang W, Zhang E, Lin C*. MicroRNAs in tumor angiogenesis. Life Sci. 2015 Sep 1;136:28-35.（通讯作者）

6. Dang B, Yang Y, Zhang E, Li W, Mi X, Meng Y, Yan S, Wang Z, Wei W, Shao C, Xing R, Lin C*. Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts. Life Sci. 2014 Mar 3;97(2):123-8. （通讯作者）

7. Lin Changjun, Wang Huan. NADPH oxidase is involved in H₂O₂-induced differentiation of human promyelocytic leukemia HL-60 cells. Cell Biol Int. 2012, 36(4): 391-395(通讯作者)

8. Chang-Jun Lin, Hung-Yao Ho, Mei-Ling Cheng, Jau-Song Yu, Daniel Tsun Yee Chiu. Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H₂O₂-induced apoptosis. Free Radic Biol Med. 2010, 49: 361-373

9. Wang Huan, Gao Huanhuan, Wang Qin, Gao Qingxiang, Lin Changjun. Special anticancer activity of a new bisalolane sesquiterpene against human leukemia cells in vitro via inducing differentiation. Pharmazie 2007, 62: 699-704 (通讯作者)

10. Lin Changjun, Kang Jiuhong, Zheng Rongliang. Oxidative stress is involved in inhibition of copper on histone acetylation in cells. Chem-Biol Interact 2005, 151(3): 167-176

11. Lin Changjun, Kang Jiuhong, Zheng Rongliang. Vitamin K3 triggers human leukemia cell death through hydrogen peroxide generation and histone hyperacetylation. Pharmazie 2005, 60(10): 765-771

12. Wang Xiao-Xiong, Lin Chang-Jun, Jia Zhong-Jian. Triterpenoids and sesquiterpenes from Mulgedium tataricum. Planta Med 2006, 72: 764-767

13. Li Ping-Lin, Lin Chang-Jun, Zhang Zhan-Xin, Jia Zhong-Jian. Three new triterpenoids from Potentilla multicaulis. Chemistry & Biodiversity 2007, 4: 17-24

14. Li Ji-Xin, Lin Chang-Jun, Yang Xiu-Ping, Jia Zhong-Jian. New bisabolane sesquiterpenes and coumarin from Leontopodium longifolium. Chemistry & Biodiversity 2006, 3: 783-790

15. Gao Xue, Lin Chang-Jun, Xie Wei-Dong, Shen Tong, Jia Zhong-Jian. New oplopane-type sesquiterpenes from Ligularia narynensis. Helvetica Chimica Acta 2006, 89: 1387-1394

16. Kang Jiuhong, Lin Changjun, Chen Jie, Liu Qing. Copper induces histone hypoacetylation through directly inhibiting histone acetyltransferase activity. Chem-Biol Interact 2004, 148(3): 115-123

17. Pan Jing, Yuan Chengshan, Lin Changjun, Jia Zhongjian, Zheng Rongliang. Pharmacological activities and mechanisms of natural phenylpropanoid glycosides. Pharmazie 2003, 58(11): 767-775

18. Kang Jiuhong, Zhang Dawei, Chen Jie, Lin Changjun, Liu Qing. Involvement of histone hypoacetylation in Ni²⁺-induced bcl-2 down-regulation and human hepatoma cell apoptosis. J Biol Inorg Chem 2004, 9(6): 713-723

19. Kang Jiuhong, Zhang Dawei, Chen Jie, Liu Qing, Lin Changjun. Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni²⁺ in human hepatoma cells. Toxicol In Vitro 2005, 19(2): 173-182

20. Kang Jiuhong, Zhang Yuntao, Chen Jie, Chen Haifeng, Lin Changjun, Wang Qin, Ou Yingxian. Nickel-induced histone hypoacetylation: the role of reactive oxygen species. Toxicol Sci 2003, 74(2): 279-286

21. Gao Xue, Lin Chang-Jun, Jia Zhong-Jian. Cytotoxic germacranolides and acyclic diterpenoides from the seeds of Carpesium triste. J Nat Prod 2007, 70: 830-834

22. Zhang Zhan-Xin, Lin Chang-Jun, Li Ping-Lin, Jia Zhong-Jian. New weakly cytotoxic eremophilane Sesquiterpenes from the roots of Ligularia virgaurea. Planta Med 2007, 73: 585-590

其他论文：

1. 林昌俊, 郑荣梁, 康九红. 基因开关, 组蛋白乙酰化和活性氧. 田亚平主编, 自由基生命科学进展, 原子能出版社, 北京, 2005, 10: 37-42

2. 王欢, 林昌俊. 活性氧调控MKP-1的研究进展. 中国科技论文在线, 2010年4月, http://www.paper.edu.cn/index.php/default/releasepaper/content/201004-234

3. 张艺馨, 张昕, 林昌俊. 丝裂原活化蛋白激酶磷酸酶-1(MKP-1)的研究进展. 中国科技论文在线, 2010年10月, http://www.paper.edu.cn/index.php /default/ releasepaper/content/201010-432

会议论文：

1. 林昌俊,康九红,郑荣梁. 细胞中组蛋白乙酰化和活性氧的关系. 第六届全国自由基生物学与自由基医学学术会议和海峡两岸自由基生物学与自由基医学学术会议. 西安，2004年。

2. 康九红,林昌俊. 活性氧、组蛋白乙酰化与重金属的毒作用. 第六届全国自由基生物学与自由基医学学术会议和海峡两岸自由基生物学与自由基医学学术会议. 西安，2004年。

3. Chang-Jun Lin, Hsin-Yu Chiu, Mei-Ling Cheng, Jau-Song Yu, Daniel Tsun-Yee Chiu. Enhancement of H₂O₂-induced Heat Shock Protein 27 Phosphorylation in Glucose-6-phosphate Dehydrogenase-knockdown HepG2 Cells. 第23届台湾生物医学联合学术年会，台北，2008年3月29-30日，P496

4. Chang-Jun Lin, Hui-Ya Liu, Mei-Ling Cheng, Jau-Song Yu, Dainel Tsun-Yee Chiu. Enhancement of H₂O₂-induced protein tyrosine phosphatase activity inhibition and MAP kinase activation in Glucose-6-phosphate dehydrogenase-knockdown HepG2 cells. 第 14 届国际自由基学术会议(The XIV Biennial Meeting of the Society for Free Radical Research International, 14th SFRR)暨第 7 届全国自由基生物学与自由基医学学术会议、第 3 届海峡两岸三地自由基生物学与自由基医学研讨会, Beijing, October 17-22, 2008, 刊登于《生物化学与生物物理进展（Progress in Biochemistry and Biophysics）》,2008,vol 35 supplement,pp269

5. Wang H, Lin C, Wang Q. Reactive oxygen species generated by NADPH oxidase are crucial for H2O2-induced differentiation of human promyelocytic leukemia HL-60 cells. 第 14 届国际自由基学术会议(The XIV Biennial Meeting of the Society for Free Radical Research International, 14th SFRR)暨第 7 届全国自由基生物学与自由基医学学术会议、第 3 届海峡两岸三地自由基生物学与自由基医学研讨会, Beijing, October 17-22, 2008, 刊登于《生物化学与生物物理进展》,2008,vol 35 supplement,pp331

6. Chang-Jun Lin, Mei-Ling Cheng, Hung-Yao Ho, Jau-Song Yu, Dainel Tsun-Yee Chiu. G6PD-knockdown exacerbates H₂O₂-induced cell apoptosis by inhibiting protein tyrosine phosphatase activity and activating MAP kinases. SFRBM 2008 - 15th Annual Meeting of the Society for Free Radical Biology and Medicine, Indianapolis, IN, USA, Poster No. 050

7. Chang-Jun Lin, Mei-Ling Cheng, Hung-Yao Ho, Jau-Song Yu, Daniel Tsun-Yee Chiu. Impaired Dephosphorylation Process Renders G6PD-Deficient Cells More Susceptible to H₂O₂-Induced Apoptosis. 第二十四届(2009年)台湾生物医学联合学术年会, 2009年3月21-22日, 口头报告, O92

著作：

1. 林昌俊 . 活性氧与信号传导及受体;活性氧与基因表达;活性氧与细胞功能和细胞效应. In: 自由基毒理学,柯跃斌,郑荣梁主编.人民卫生出版社.北京,2012年12月,82-101页

2. 林昌俊, 谭晓荣. 活性氧调控信号传导、基因表达和细胞功能. In:自由基生物学(第三版),郑荣梁, 黄中洋主编, 高等教育出版社, 北京, 2007年6月, 第6章, 85-122页

3. 林昌俊. 16章. 活性氧的訊息傳遞作用；17章. 活性氧對基因的調控. In: 自由基生物学与医学,郑荣梁,魏耀挥,赵崇义,黄中洋主编.台湾艺轩图书出版社,2013年4月,339-387页