漆永梅
个人简历
科研成果
教学情况
研究方向
荣誉奖励
论文专著
其他信息
个人简历
基本信息
职称：副教授
办公室地址：天演楼439室
邮箱：qiym@lzu.edu.cn
学习经历
2005/09-2011/07，兰州大学，生命科学学院，硕博连读/博士
2008/09-2010/07，美国马里兰大学帕克分校（University of Maryland, College Park），“国家建设高水平大学公派研究生项目”联合培养博士研究生
2001/09-2005/07，河南师范大学，生命科学学院，本科/学士
工作经历
2016.05-今，兰州大学，生命科学学院，副教授
2011/07-2016.04，兰州大学，生命科学学院，讲师
2008/07-2011/06，兰州大学联合培养研究生师资
社会工作
甘肃省抗癌协会第三届理事会理事
科研成果
1.主持国家自然科学基金青年项目1项
2.主持甘肃省自然科学基金项目2项
3.主持细胞活动与逆境适应教育部重点实验室开放基金1项
4.主持甘肃省外科肿瘤分子诊断与精准治疗重点实验室开放基金1项
5.主持中央高校基本科研业务费项目3项
教学情况
1. 本科教学：主讲《生物化学》和《生物化学实验》
（1）教材和课程建设：参与出版《Biochemistry生物化学（英文版）》教材（高等教育出版社，2012）；以第二编者出版《生物化学实验》数字课程（高等教育出版社、高等教育电子音像出版社，2023）；作为核心成员获批国家级一流课程《生物化学实验》，省级一流课程《生物化学》和《生物化学实验》。
（2）教学研究：作为核心成员获批“2024年甘肃省大中小学课程教材专项研究课题”；主持完成院级教学研究项目一项；获兰州大学2023年度校级教学成果奖一等奖，排名3/6。
2. 研究生教学及科研：承担研究生《高级生物化学》、《环境生物监测-动物学专题》和《动物毒理学》课程教学，指导的硕士研究生中2人获甘肃省优秀研究生“创新之星”项目资助。
欢迎对细胞内稳态与线粒体质量控制方向感兴趣的同学报考学术型硕士研究生！
欢迎对生物与医药方向感兴趣的同学报考专业型硕士研究生！
研究方向
1.细胞内稳态和线粒体质量控制的分子机制研究：以哺乳动物细胞和小鼠为模型研究线粒体生物发生、线粒体融合分裂、线粒体自噬和线粒体运动的影响因素及分子机制，并解析其与癌症、神经退行性疾病的关系。
2.甘肃省特色中药的抗肿瘤效应及机制：大黄素、黄芩苷等对肿瘤细胞死亡（主要关注细胞自噬、铁死亡和凋亡）、肿瘤微环境的潜在影响及分子机制。
荣誉奖项
1.指导本科生完成大学生生命科学竞赛项目（2021，科学探究类），分获甘肃省和全国一等奖。
2.2023年获优秀本科论文指导教师称号。
3.2021年获优秀班主任称号。
论文专著
1. Mengchen Xu#, Xu Gao#, Lu Yue, Jinyu Li, Xiaoya Feng, Dejun Huang, Hui Cai*, Yongmei Qi*. Sensitivity of triple negative breast cancer cells to ATM-dependent ferroptosis induced by sodium selenite. Experimental Cell Research. 2024, 29;442(2):114222.
2. Yihong Tian, Yongmei Qi*, Hui Cai*, Mengchen Xu, Yingmei Zhang. Senegenin alleviates Aβ1-42 induced cell damage through triggering mitophagy. Journal of Ethnopharmacology. 2022, 295:115409.
3. Yan Hu, Xuan Ma, Rongjian Liu, Iqra Mushtaq, Yongmei Qi, Cong Yuan, and Dejun Huang*. 2,4-Dichlorophenol Increases Primordial Germ Cell Numbers via ESR2a-Dependent Pathway in Zebrafish Larvae. Environmental Science & Technology. 2022, 56, 13878-13887.
4. Yongmei Qi#, Lin Ma#1, Sajid Naeem, Xueyan Gu2, Xijuan Chao, Cong Yuan, Dejun Huang*. Pb induced mitochondrial fission of fibroblast cells via ATM activation. Journal of Hazardous Materials, 2021, 416: 126177.
5. Xingjie Zhang, Lin Ma, Yue Tang, Jiangyuan Han, Yongmei Qi*, Dejun Huang*. Low-dose cadmium exposure facilitates cell proliferation by promoter hypermethylation of RASSF1A and DAPK1 genes. Environmental Toxicology. 2021, 36(11):2313-2321.
6. Yihong Tian, Yongmei Qi*, Sajid Naeem, Ke Gao, Yingmei Zhang*. Spermidine-Induced Autophagy Regulates the Survival of HeLa Cells. Pakistan Journal of Zoology, 2021, 53(1):239-244.
7. Yan Hu1, Dong Li1, Xuan Ma, Rongjian Liu, Yongmei Qi, Cong Yuan, Dejun Huang*. Effects of 2,4-dichlorophenol exposure on zebrafish: Implications for the sex hormone synthesis. Aquatic Toxicology, 2021, 236: 105868.
8. Jiangyuan Han, Yan Hu, Yongmei Qi, Cong Yuan, Sajid Naeem, Dejun Huang*. High temperature induced masculinization of zebrafish by down-regulation of sox9b and esr1 via DNA methylation. Journal of Environmental Sciences, 2021, 107: 160-170.
9. Ke Gao, Chengfei Zhang, Yihong Tian, Sajid Naeem, Yingmei Zhang, Yongmei Qi*. The role of endoplasmic reticulum stress in lead (Pb)-induced mitophagy of HEK293 cells. Toxicology and Industrial Health, 2020, 36(12): 1002-1009.
10. Xijuan Chao*, Yongmei Qi, Yingmei Zhang*. Highly Photostable Fluorescent Tracker with pH-Insensitivity for Long-Term Imaging of Lysosomal Dynamics in Live Cells. ACS Sensors, 2020.
11. Sajid Naeem, Yongmei Qi*, Yihong Tian, Yingmei Zhang*. NIX compensates lost role of Parkin in Cd-induced mitophagy in HeLa cells through phosphorylation. Toxicology Letters, 2020, 326:1-10.
12. Chen Zhang, Dong Li, Tingting Ge, Jiangyuan Han, Yongmei Qi*, Dejun Huang*. 2,4-Dichlorophenol induces feminization of zebrafish (Danio rerio) via DNA methylation. Science of the Total Environment, 2020, 708:135084.
13. Cong Yuan, Chen Zhang, Yongmei Qi, Dong Li, Yan Hu, Dejun Huang*. 2,4-Dichlorophenol induced feminization of zebrafish by down-regulating male-related genes through DNA methylation. Ecotoxicology and Environmental Safety, 2019, 173:243-250.
14. Xueyan Gu, Yongmei Qi*,Zengxiu Feng,Lin Ma, Ke Gao,Yingmei Zhang*. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicology Letters, 2018, 291:92-100.
15. Yongmei Qi#, Qian Qiu#, Xueyan Gu, Yihong Tian, Yingmei Zhang*. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Scientific Reports, 2016, 6, 24700.
16. Yongmei Qi, Yingmei Zhang*, Yingxia Liu, Wenya Zhang. Nonylphenol decreases viability and arrests cell cycle via reactive oxygen species in Raji cells. Experimental and Toxicologic Pathology, 2013, 65 (1-2): 69-72.
17. Yongmei Qi, Ailing Li, Dejun Huang, Yihong Tian, Yingmei Zhang*. Exogenous S-adenosyl-L-methionine could inhibit c-myc overexpression induced by As2O3 in normal human liver HL-7702 cells. Journal of Health Science, 2011, 57(2): 188-191.
18. Yongmei Qi, Norberta W Schoene, Frederick M Lartey, Wen-Hsing Cheng*. Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells. Journal of Biological Chemistry, 2010, 285(43): 33010–33017.
19. Dejun Huang*, Xiaoning Zhang, Chen Zhang, Hui Li, Dong Li, Yan Hu, Feng Yang, Yongmei Qi. 2,4-Dichlorophenol induces DNA damage through ROS accumulation and GSH depletion in goldfish Carassius auratus. Environ Mol Mutagen, 2018, 59:798-804.
20. Tingting Ge, Jiangyuan Han, Yongmei Qi, Xueyan Gu, Lin Ma, Chen Zhang, Sajid Naeem, Dejun Huang*. The toxic effects of chlorophenols and associated mechanisms in fish. Aquatic Toxicology, 2017, 184:78-93.
21. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, Yingmei Zhang*. ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain. Neurotoxicology, 2015, 46:19-24.
22. Xue Wei, Yongmei Qi, Xiaoning Zhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun Huang, Yingmei Zhang*. Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway. Toxicology Mechanisms and Methods, 2014, 24(7):504-511.
23. Zhen An, Yongmei Qi, Dejun Huang, Xueyan Gu, Yihong Tian, Ping Li, Hui Li, Yingmei Zhang*. EGCG inhibits Cd2+-induced apoptosis through scavenging ROS rather than chelating Cd2+ in HL-7702 cells. Toxicology Mechanisms and Methods, 2014, 24(4): 259-267.
24. Xiaoning Zhang, Xiaona Zhang, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4-Dichlorophenol induces ER stress-mediated apoptosis via eIF2a dephosphorylation in vitro. Environmental Toxicology, 2016, 31(2): 245-255.
25. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Jufang Wang, Dejun Huang*. Cadmium delays non-homologous end joining (NHEJ) repair viainhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and Ligase IV. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2015, 779: 112-123.
26. Xiaoning Zhang, Xiaona Zhang, Zhidan Niu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4,6-Trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis. International Journal of Toxicology, 2014, 33(6): 532-541.
27. Xiaoning Zhang, Hui Li, Qian Qiu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4-Dichlorophenol induces global DNA hypermethylation through the increase of S-adenosylmethionine and the upregulation of DNMTs mRNA in the liver of goldfish Carassius auratus. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 2013, 160C: 54-59.
28. Hui Li, Xiaoning Zhang, Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway. Aquatic Toxicology, 2013, 140-141: 117-122.
29. Peng Chen, Yingxia Liu, Yanqing Sun, Che Chen, Yongmei Qi, Yingmei Zhang*. AZT and emodin exhibit synergistic growth-inhibitory effects on K562/ADM cells by inducing S phase cell cycle arrest and suppressing MDR1 mRNA/p-gp protein expression. Pharmacology Biology, 2013, 51(12):1586-1591.
其他信息
