纵向项目

主持：
1. 国家自然科学基金青年项目，31501860，采用同园实验研究青海沙蜥幼体种群间适应环境特征及其形成机制，2016/01-2018/12；
2. 中央高校基本科研业务费专项资金自由探索项目，lzujbky-2022-55，高原林蛙皮肤抗氧化肽的分离鉴定和活性研究，2022/01-2024/06；
3. 中央高校基本科研业务费专项资金自由探索项目，lzujbky-2015-81，不同海拔青海沙蜥体温调节研究，2015/01-2016/06；

参与：
1. 国家自然科学基金面上项目，32270502，高原林蛙越冬的行为和生理机制研究，2023-01至2026-12;
2. 国家自然科学基金面上项目，31971416，倭蛙个体发育不同阶段对温度变化的响应，2020-01至2023-12;
3. 国家自然科学基金面上项目，31472005，红尾沙蜥适应和耐受低温的机制，2015/01-2018/12;
4. 国家自然科学基金面上项目，31272313，青海沙蜥和红尾沙蜥对高原低氧的适应机制研究，2013/01-2016/12；
5. 国家自然科学基金面上项目，31071918，三种沙蜥的性别决定机制以及孵化温度对其幼体生存能力影响的研究，2011/01-2011/12；
6. 国家自然科学基金面上项目，30670263，密点麻蜥性别决定机制的研究，2007/01-2009/12；

横向项目：两项，主持

本科生教学:
讲授《动物生理学》、《动物多样性与动物生态》以及《人体解剖生理学》，讲授并指导《动物生理学实验》和《基础生物学实验》。
研究生教学:
讲授《极端环境生理学》、《多肽研究进展》。

青藏高原两栖爬行动物环境适应性机制；

爬行动物温度依赖性性别决定；

1.          Zhang, T., Z. Niu, J. He, P. Pu, F. Meng, L. Xi, X. Tang, L. Ding, M. Ma and Q. Chen (2023). "Potential Effects of High Temperature and Heat Wave on Nanorana pleskei Based on Transcriptomic Analysis." Current Issues in Molecular Biology 45(4): 2937-2949.

2.          Ma M, Pu P, Niu Z, Zhang T, Wu J, Tang X and Chen Q (2023) A novel mechanism for highaltitude adaptation in hemoglobin of blackspotted frog (Pelophylax nigromaculatus). Front. Ecol. Evol. 11:1103406. doi: 10.3389/fevo.2023.1103406

3.          Iromini, T., X. Tang, K. N. Holloway and C. Hou (2023). "Link between Energy Investment in Biosynthesis and Proteostasis: Testing the Cost–Quality Hypothesis in Insects." Insects 14(3): 241.

4.          Tang, X., L. Xi, Z. Niu, L. Jia, Y. Bai, H. Wang, M. Ma and Q. Chen (2022). "Does a Moderately Warming Climate Compensate for the Negative Effects of UV-B Radiation on Amphibians at High Altitudes? A Test of Rana kukunoris Living on the Qinghai-Tibetan Plateau." Biology 11(6): 838.

5.          Ma, M., S. Luo, X. Tang and Q. Chen (2022). "Age structure and growth pattern of a high‐altitude lizard population based on age determination by skeletochronology." Journal of Experimental Zoology Part A: Ecological and Integrative Physiology.

6.          Niu, Y., Q. Chen, K. B. Storey, L. Teng, X. Li, T. Xu and H. Zhang (2022). "Physiological Ecology of Winter Hibernation by the High-Altitude Frog Nanorana parkeri." Physiological and Biochemical Zoology 95(3): 201-211.

7.          Qi, Y., T. Zhang, Y. Wu, Z. Yao, X. Qiu, X. Tang, J. Fu and W. Yang (2022). "A multi-level assessment of plasticity in response to high-altitude environment for agama lizards." Frontiers in Ecology and Evolution: 178.

8.          ZHU, X., X. QIU, X. TANG and Y. QI (2021). "Tail display is regulated by anaerobic metabolism in an Asian agamid lizard." Integrative Zoology 16(5): 729-740.

9.          Lin, Z., K. Yu, L. Shen, Y. Zhang, Y. Liu, M. Hou, Z. Peng, X. Tang and Q. Chen (2021). "A staging table of embryonic development for a viviparous (live-bearing) lizard Eremias multiocellata (Squamata: Lacertidae)." Reproduction, Fertility and Development.

10.       Pu, P., Y. Zhao, Z. Niu, W. Cao, T. Zhang, J. He, J. Wang, X. Tang and Q. Chen (2021). "Comparison of hematological traits and oxygenation properties of hemoglobins from highland and lowland Asiatic toad (Bufo gargarizans)." J Comp Physiol B.

11.       Niu, Z., M. Li, P. Pu, H. Wang, T. Zhang, X. Tang and Q. Chen (2021). "Effects of temperature on the locomotor performance and contraction properties of skeletal muscle from two Phrynocephalus lizards at high and low altitude." Journal of Comparative Physiology B 191(5): 907-916.

12.       He, J., X. Tang, P. Pu, T. Zhang, Z. Niu, F. Meng, L. Xi, M. Ma, J. Wu, M. Ma and Q. Chen (2021). "Influence of High Temperatures and Heat Wave on Thermal Biology, Locomotor Performance, and Antioxidant System of High-Altitude Frog Nanorana pleskei Endemic to Qinghai-Tibet Plateau." Frontiers in Ecology and Evolution 9(831).

13.       Niu, Y., X. Zhang, H. Zhang, T. Xu, L. Zhu, K. B. Storey and Q. Chen (2021). "Metabolic responses of plasma to extreme environments in overwintering Tibetan frogs Nanorana parkeri: a metabolome integrated analysis." Frontiers in zoology 18(1): 1-13.

14.       Niu, Y., W. Cao, K. B. Storey, J. He, J. Wang, T. Zhang, X. Tang and Q. Chen (2020). "Metabolic characteristics of overwintering by the high-altitude dwelling Xizang plateau frog, Nanorana parkeri." J Comp Physiol B 190(4): 433-444.

15.       Wenyun Zuo, X. T., Chen Hou (2020). "Why Naked Mole-Rats Have High Oxidative Damage but Live a Long Life: A Simple Explanation Based on the Oxidative Stress Theory of Aging." Advances in Geriatric Medicine and Research.

16.       Niu, Y., W. Cao, J. Wang, J. He, K. B. Storey, L. Ding, X. Tang and Q. Chen (2020). "Freeze tolerance and the underlying metabolite responses in the Xizang plateau frog, Nanorana parkeri." J Comp Physiol B.

17.       Pu, P., S. Lu, Z. Niu, T. Zhang, Y. Zhao, X. Yang, Y. Zhao, X. Tang and Q. Chen (2019). "Oxygenation properties and underlying molecular mechanisms of hemoglobins in plateau zokor (Eospalax baileyi)." Am J Physiol Regul Integr Comp Physiol 317(5): R696-R708.

18.       Niu, Y., W. Cao, Y. Zhao, H. Zhai, Y. Zhao, X. Tang and Q. Chen (2018). "The levels of oxidative stress and antioxidant capacity in hibernating Nanorana parkeri." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 219-220: 19-27.

19.       Zhang, W., N. Li, X. Tang, N. Liu and W. Zhao (2018). "Changes in intestinal microbiota across an altitudinal gradient in the lizard Phrynocephalus vlangalii." Ecol Evol 8(9): 4695-4703.

20.       Niu, Y., J. Wang, S. Men, Y. Zhao, S. Lu, X. Tang and Q. Chen (2018). "Urea and plasma ice-nucleating proteins promoted the modest freeze tolerance in Pleske's high altitude frog Nanorana pleskei." J Comp Physiol B.

21.       Wang, H., X. Tang, Y. Wang, Y. Feng, P. Pu, S. Men, Y. Zhao, Z. Peng and Q. Chen (2018). "Function of Lactate Dehydrogenase in Cardiac and Skeletal Muscle of Phrynocephalus Lizard in Relation to High-Altitude Adaptation." Asian Herpetological Research 9(4): 258-+.

22.       Li, X., Y. Wang, S. Lu, M. Li, S. Men, Y. Bai, X. Tang and Q. Chen (2017). "The Cold Hardiness of Phrynocephalus erythrurus, the Lizard Living at Highest Altitude in the World." Cryoletters 38(3): 216-227.

23.       Li, W., S. Liang, H. Wang, Y. Xin, S. Lu, X. Tang and Q. Chen (2016). "The effects of chronic hypoxia on thermoregulation and metabolism in Phrynocephalus vlangalii." Asian Herpetological Research 7: 109-117.

24.       Liang, S., W. Li, Z. Yang, X. Tang, J. He, Y. Bai, D. Li, W. Yan and C. Qiang (2016). "Seasonal variation of metabolism in lizard Phrynocephalus vlangalii at high altitude." Comparative Biochemistry & Physiology Part A Molecular & Integrative Physiology.

25.       Xin, Y., X. Tang, H. Wang, S. Lu, Y. Wang, Y. Zhang and Q. Chen (2015). "Functional characterization and expression analysis of myoglobin in high-altitude lizard Phrynocephalus erythrurus." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 188: 31-36.

26.       Lu, S., Y. Xin, X. Tang, F. Yue, H. Wang, Y. Bai, Y. Niu and Q. Chen (2015). "Differences in Hematological Traits between High-and Low-Altitude Lizards (Genus Phrynocephalus)." PloS one 10(5).

27.       Wang, C., X. Tang, Y. Xin, F. Yue, X. Yan, B. Liu, B. An, X. Wang and Q. Chen (2015). "Identification of Sex Chromosomes by Means of Comparative Genomic Hybridization in a Lizard, Eremias multiocellata." Zoological science 32(2): 151-156.

28.       Zhang, Y., S. Liang, J. He, Y. Bai, Y. Niu, X. Tang, D. Li and Q. Chen (2015). "Oxidative stress and antioxidant status in a lizard Phrynocephalus vlangalii at different altitudes or acclimated to hypoxia." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 190: 9-14.

29.       Yang, Y., L. Wang, J. Han, X. Tang, M. Ma, K. Wang, X. Zhang, Q. Ren, Q. Chen and Q. Qiu (2015). "Comparative transcriptomic analysis revealed adaptation mechanism of Phrynocephalus erythrurus, the highest altitude Lizard living in the Qinghai-Tibet Plateau." BMC evolutionary biology 15(1): 101.

30.       XIN, Y., H. WANG, X. TANG, S. LU, W. LI, Y. ZHANG, S. LIANG and Q. CHEN (2014). "Characterisation and Expression Analysis of Sox9 in the Multiocellated Racerunner, Eremias multiocellata." Asian Herpetological Research 2: 004.

31.       He, J., M. Xiu, X. Tang, F. Yue, N. Wang, S. Yang and Q. Chen (2013). "The different mechanisms of hypoxic acclimatization and adaptation in Lizard Phrynocephalus vlangalii living on Qinghai-Tibet Plateau." J Exp Zool A Ecol Genet Physiol 319(3): 117-123.

32.       Xiaolong Tang, Ying Xin, Huihui Wang, Weixin Li, Yang Zhang, Shiwei Liang, Jianzheng He, Ningbo Wang, Ming Ma and Q. Chen* (2013). "Metabolic Characteristics and Response to High Altitude in Phrynocephalus erythrurus (Lacertilia: Agamidae), a Lizard Dwell at Altitudes Higher Than Any Other Living Lizards in the World." PLoS One.

33.       Tang, X.-L., F. Yue, D.-J. Zhang, X.-F. Yan, Y. Xin, C. Wang and Q. Chen (2012). "The effect of operational sex ratio on sex allocation and neonate phenotype in a viviparous lizard Eremias multiocellata." Amphibia-Reptilia 33(3-4): 485-493.

34.       Xiaolong Tang, Feng Yue, Ming Ma, Ningbo Wang, Jianzheng He and Q. Chen (2012). "Effects of thermal and hydric conditions on egg incubation and hatchling phenotypes in two Phrynocephalus lizards." Asian Herpetological Research 3: 002.

35.       Xin, Y., X. Tang, F. Yue, D. Zhang, X. Yan, C. Wang and Q. Chen (2012). "Isolation and sequence analysis of Sox genes from lizard Eremias multiocellata." Russian Journal of Genetics 48(1): 79-85.

36.       Xin, Y., Y. Wang, H. Wang, X. Tang, Y. Bai and S. Lu (2019). "The response of nitric oxide system to high Altitude in Phrynocephalus erythrurus on Qinghai-Tibetan plateau." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 230: 29-36.

37.       Yue, F., X.-L. Tang, D.-J. Zhang, X.-F. Yan, Y. Xin and Q. Chen (2012). "Body temperature and standard metabolic rate of the female viviparous lizardEremias multiocellataduring reproduction." Canadian Journal of Zoology 90(1): 79-84.

38.       Yan, Xue-Feng, Tang, Xiao-Long, Yue, Feng, Zhang, De-Jiu, Xin and Ying (2011). "Influence of ambient temperature on maternal thermoregulation and neonate phenotypes in a viviparous lizard, Eremias multiocellata, during the gestation period." Journal of Thermal Biology 36(3): 187-192.

39.       Zhang, D.-J., X.-L. Tang, F. Yue, Z. Chen and Q. Chen (2010). "Effect of gestation temperature on sexual and morphological phenotypes of offspring in a viviparous lizard, Eremias multiocellata." Journal of Thermal Biology 35(3): 129-133.

40.       Fu, C. Y., X. L. Tang, Q. Yang, Q. Chen and R. Wang (2007). "Effects of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on the antinociceptive activity of pethidine administered at the peripheral and supraspinal level." Behav Brain Res 184(1): 39-46.