高岚
个人简历
科研成果
教学情况
研究方向
荣誉奖励
论文专著
个人简历
基本信息
职称:教授
办公室地址:412
联系电话:0931-8912560
邮箱:gaolan@lzu.edu.cn
学习经历
1997-2007年,分别获得兰州大学生命科学学院动物学专业理学硕士和博士学位。
2002-2003年,作为国家公派访问学者赴加拿大、安大略省皇家博物馆(ROM)生物保护与生物多样性中心,从事亚洲无尾两栖类动物斑腿树蛙(R . megacephalus)有关分子遗传学与系统发生的研究工作。
Educational history:
Sept 2004- Dec 2007 Ph.D (Zoology) The Lanzhou University
Jul 1994 - Jun 1997 MSc (Zoology) The Lanzhou University
Jul 1982 - Jun 1986 BSc (Biology) The ShangHai Ocean University
工作经历
1986年8月至1991年1月,在甘肃农业大学基础部,任助教,讲师。
1991年至今,在兰州大学生命科学学院,任副教授。
2012年至今,任教授,博士生导师。
社会工作
中国动物学会两栖爬行动物学分会理事
中国动物学会生理生态分会理事
甘肃省林业自然保护区评审委员会委员
甘肃省水产学会副理事长
科研成果
近年来承担的科研项目:
1. Pax6基因和Pax6基因突变体在非洲爪蟾眼睛发育过程中的相互作用及分子机制 (批准号:31471953),国家自然科学基金面上项目,项目起止年月:2015年01月至 2018年12月,项目负责人
2. 紫外辐射引起角膜上皮细胞凋亡的分子机理研究(批准号:30970312).国家自然科学基金面上项目,项目负责人
3. 无尾两栖类蝌蚪晶状体再生的分子机理研究(批准号:30570224).国家自然科学基金面上项目,项目负责人
4. 冷水性鱼优良新品种的引进及新技术试验示范推广(批准号:20090478). 甘肃省星火计划项目,项目负责人
5.国家林业局玛曲湿地生态保护示范工程项目. 国家林业局湿地项目,项目负责人。
6. 黄河首曲自然保护区生物多样性调查(批准号:20101209-364),甘肃省甘南藏族自治州,项目负责人。
7.无尾两栖类晶状体再生相关基因的分析测定,甘肃省自然科学基金(批准号:3ZS061-A25-060),项目负责人。
8.甘肃黄河首曲湿地黑颈鹤的种群数量动态和食性分析,中国野生动物保护协会,项目负责人。
9.教学标本标准化整理整合及共享,(批准号:2005DKA21403),科技部十一五重大专项,主要参加人。
10.青藏高原社区天然草地保护与合理利用技术研究与示范,国家农业部公益性行业(农业)科研专项(批准号:201203006)。
11.紫外辐射引起无尾两栖类角膜上皮细胞凋亡的分子机理研究,甘肃省自然科学基金(批准号:2011GS04080),项目负责人。
12.氧化石墨烯的小鼠眼毒性评估,甘肃省自然科学基金(批准号:17JR5RA220),2017年9月至2019年9月,项目负责人。
教学情况
本科生课程:
动物生物学(生科基地班,本科生主干课程,甘肃省精品课程);
神经生物学(萃英学院本科生课程)
生物学野外实习(生科、基地班);生物显微技术 (2000-2004年全院本科生)
研究生课程:
发育神经生物学
2001年任硕士研究生导师,2012任博士生导师;先后培养了近40名硕士研究生;现指导在校硕士研究生5名、博士研究生5名。
研究方向
晶状体再生相关基因及蛋白表达研究
角膜上皮细胞凋亡的分子机理
荣誉奖项
甘肃省第十届高校青年教师成才基金,2004年10月
兰州大学首届“隆基教育教学奖”,2007年12月
兰州大学第二届 “教学新秀一等奖”,2000年12月
2010年获得甘肃省科技进步二等奖(3/6)2010年10月
2013年获得兰州大学教学成果一等奖(2/5),2013年9月
2014年获得甘肃省教学成果二等奖(2/5),2014年4月
论文专著
近期研究论文:
1. Wang J, Yang Y, Shi Y, Wei L, Gao L, Liu M. Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis. Environment International. 2024 Mar 7:108523.(中科院一区;Top;IF = 11.8)
2. Shi Y, Wei L, Jin F, Wang J, Cao H, Yang Y, Gao L. Colchicine disrupts bile acid metabolic homeostasis by affecting the enterohepatic circulation in mice. Journal of Applied Toxicology. 2024 Feb 4.(中科院三区;IF = 3.3)
3.Wang, J., Tian, H., Shi, Y., Yang, Y., Yu, F., Cao, H., ... & Liu, M. (2023). The enhancement in toxic potency of oxidized functionalized polyethylene-microplastics in mice gut and Caco-2 cells. Science of The Total Environment, 166057.(中科院一区;Top;IF = 9.8)
4.Cao, H., Shi, Y., Wang, J., Niu, Z., Wei, L., Tian, H., ... & Gao, L. (2023). The intestinal microbiota and metabolic profiles of Strauchbufo raddei underwent adaptive changes during hibernation. Integrative Zoology.(中科院一区;IF = 3.3)
5.Wang, J., Cao, H., Shi, Y., Tian, H., Yu, F., Liu, M., & Gao, L. (2023). Exposure to nitrate induced growth, intestinal histology and microbiota alterations of Bufo raddei Strauch tadpoles. Aquatic Toxicology, 258, 106477.(中科院二区;IF = 4.5)
6.Shi, Y., Li, J., Wang, J., Cao, H., Tian, H., Yu, F., & Gao, L. (2022). Colchicine increases intestinal toxic load by disturbing fecal metabolome homeostasis in mice. Chemico-Biological Interactions, 368, 110193.(中科院二区;IF = 5.1)
7.Yang, P., Wei, L., Tian, H., Yu, F., Shi, Y., & Gao, L. (2022). Gadolinium chloride protects neurons by regulating the activation of microglia in the model of optic nerve crush. Biochemical and Biophysical Research Communications, 618, 119-126.(中科院三区;IF = 3.1)
8.WEI Li1, MA Wei, CAI Hui, PENG Shao Peng, TIAN Huan Bing, WANG Ju Fang, GAO Lan, and HE Jin Peng:Inhibition of Ciliogenesis Enhances the Cellular Sensitivity to Temozolomide and Ionizing Radiation in Human Glioblastoma Cells. Biomed Environ Sci, 2022, 35(5):419-436(中科院三区;IF = 3.5)
9.Pengfei Yang, Linchi Chen, Yongpeng Shi, Fangfang Zhou, Huanbing Tian, Jiande Li, Lan Gao* Progesterone alters the activation and typing of the microglia in the optic nerve crush model. Experimental Eye Research, Volume 212, (November 2021), 108805. (中科院二区,IF = 3.467)
10.Yongpeng Shi, Hui Cai, Zhanyu Niu, Jiande Li, Gaowei Pan, Huanbing Tian, Li Wei, Linchi Chen, Pengfei Yang, Ji Wang, Hanwen Cao, Lan Gao* Acute oral colchicine caused gastric mucosal injury and disturbance of associated microbiota in mice. Toxicology, Volume 461, (September 2021), 152908. (中科院二区,影响因子4.221)
11.Zhanyu Niu, Yongpeng Shi, Jiande Li, Shufan Qiao, Shaobo Du, Linchi Chen, Huanbing Tian, Li Wei, Hanwen Cao, Ji Wang, Lan Gao* Protective effect of rapamycin in models of retinal degeneration. Experimental Eye Research, Volume 210, (September 2021), 108700. (中科院二区,IF = 3.467)
12.Jiande Li, Shaobo Du, Yongpeng Shi, Jiangyuan Han, Zhanyu Niu, Li Wei, Pengfei Yang, Linchi Chen, Huanbing Tian, Lan Gao* Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes. Experimental Eye Research, Volume 203, (February 2021), 108399. (中科院二区,IF = 3.467)
13.Yongpeng Shi, Jiande Li, Pengfei Yang, Zhanyu Niu, Li Wei, Linchi Chen, Lan Gao* Colchicine increases intestinal permeability, suppresses inflammatory responses,and alters gut microbiota in mice. Toxicology Letters (2020),Volume 334, 1 November 2020, Pages 66-77(中科院三区;IF = 3.5)
14.Shaobo Du, Jiande Li, Linchi Chen, Zhanyu Niu, Lan Gao*. Dynamic changes in and time sequence of ultraviolet B-induced apoptosis in rat corneal epithelial cells. Arquivos Brasileiros de Oftalmologia.(2020) (Accepted; vol:ABO 85, iss:3).
15.Wenzhen Ana, Ying Zhanga, Xuan Zhanga, Kang Lia, Yujun Kangb, Shahnaz Akhtara, Xueli Shaa, Lan Gao* "Ocular toxicity of reduced graphene oxide or graphene oxide exposure in mouse eyes" Experimental Eye Research 174 (2018) 59–69
16.Shahnaz Akhtar, Wenzhen An, Xiaoying Niu, Kang Li, Shahzad Anwar, Khan Maaz, Muhammad Maqbool, Lan Gao* “Toxicity of PEG-Coated CoFe2O4 Nanoparticles with Treatment Effect of Curcumin” Nanoscale Research Letters 13 (2018) 52.
17.Shaobo Du, Biao Han, Kang Li, Xuan Zhang, Xueli Sha, and Lan Gao* Lycium barbarum Polysaccharides Protect Rat Corneal Epithelial Cells against Ultraviolet B-Induced Apoptosis by Attenuating the Mitochondrial Pathway and Inhibiting JNK Phosphorylation, BioMed Research International, Volume 2017 (2017), p. 5806832
18.Wenzhen An, Biao Han, Kang Li, Shahnaz Akhtar, Ying Zhang, Xuan Zhang, Xueli Sha, Lan Gao* The protective study about alleviation of simvastatin on the damages of
PEG-BNs in mice, Environmental Toxicology and Pharmacology 53C (2017) pp. 64-73.
19.Ju, Furong; Zhao, Yongqing; Zhao, Yuanlin; Wang, Ying; Wen, Fan; Ye, Lin; Lan Gao*, Interaction between Pax6 and its novel mutant in Bufo raddei Strauch, MOLECULAR VISION, 17(292), pp 2698-2705, 2011/10/18.
20.Zhao, Yongqing; Ju, Furong; Zhao, Yuanlin; Wang, Lei; Sun, Zhenglong; Liu, Mingxin; Lan Gao*, The expression of alpha A- and beta B1-crystallin during normal development and regeneration, and proteomic
analysis for the regenerating lens in Xenopus laevis, MOLECULAR VISION, 17(87), pp 768-778, 2011/3/23.
21.Xu, Hua; Gao Lan; Che, Tuanjie; Du, Wenjing; Li, Qiang; Gao, Qingxiang; *Wang, Ziren, The Effects of C-12(6+) Irradiation on Cell Cycle, Apoptosis, and Expression of Caspase-3 in the Human Lung Cancer Cell
Line H1299, Cancer Biotherapy and Radiopharmaceuticals, 27(2), pp 113-118, 2012/3.
22.Liu Yong; Wang Rong; Gao Lan; Jia Zhengping; Xie Hua; Zhang Junli; Ma Jun; Zhang Aimei; Xie Xihui, Capillary Electrophoresis Detection of Lung Cancer and Adjacent Normal Tissue Differences in Protein Mixture,
ACTA CHIMICA SINICA, 69(5), pp 543-547, 2011/3/14.
23.Gao, Lan.; Sun, Y.; Chen, C.; Xi, Y.; Wang, J.; Wang, Z., Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ss prepared from the mushroom Agaricus blazei Murill,
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 40(11), pp 1545-1555, 2007/11.
24.Liu Yong; Wang Rong; Gao Lan; Jia Zheng-Ping; Xin Xiao-Ting; Xie Hua; Ma Jun, Methodology Research on P53 Gene Mutation Detection Exon 7 of Lung Cancer by Capillary Electrophoresis with
Single Strand Conformation Polymorphism and Restriction Fragment Length Polymorphism, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 37(10), pp 1494-1498, 2009/10.
25.Jianlin Wang,Gao Lan,Cui-Sheng,Gen-Xuan Wang and Hai-Yan Li:The arterial supply of the cubital joint in the bactrian camel. The Veterinary Research Communications, 2000,24(1):1-9.
26.Jianlin Wang,Gao Lan,Gen-Xuan Wang and Hai-Yan Li: The arterial supply to the digits of the forelimb in the Bactrian camel (Camelus bactrianus), Journal of Anatomy, 2000,196(2): 193-202.
27.Jianlin Wang,Gao Lan,Cui-Sheng, Gen-Xuan Wang and Hai-Yan Li: Anatomical subdivisions of the stomach of the bactrian camel (Camelus bactrianus). Journal of Morphology, 2000,245(2):161-167.
28. Blair, Christopher; Davy, Christina M.; Ngo, Andre; Orlov, Nikolai L.; Shi, Hai-tao; Lu, Shun-qing;Gao Lan; Rao, Ding-qi; Murphy, Robert W. Genealogy and Demographic History of a Widespread
Amphibian throughout Indochina JOURNAL OF HEREDITY, 104(1), pp 72-85, 2013/2 JAN-FEB.
教材、著作、译著
1. 生物学综合野外实习指导(冯虎元,高岚主编),2011年6月出版,高等教育出版社 (书号:978-7-04-032700-7,35万字)
2. 动物生物学实验指导(双语),2003出版,兰州大学出版社,3/3.
3. 甘肃黄河首曲省级自然保护区综合科学考察报告(主编),2011年.