主讲本科生《遗传学》课程；

主讲研究生《自由基生物学》和《生物物理学进展》课程。

指导生物物理专业 自由基生物学方向 硕士研究生。

现主要研究方向为线粒体移植（mitochondrial transplantation, MT）作用和机制。有如下发现：

1）MT对于紫外辐照诱导的细胞损伤具有疗效，线粒体结构完整性决定移植效果，破碎线粒体所含成分无MT效果（https://doi.org/10.1016/j.jphotobiol.2022.112534）。

2）MT对小鼠皮肤急性光损伤具疗效。

3）MT对小鼠皮肤烧伤具疗效（https://doi.org/10.1016/j.freeradbiomed.2024.02.019），MT具有免疫调节作用，提出MT内化机制和非内化机制假说（23-07-10-10-56-23-896.pdf (cjcb.org)）。

目前继续在疗效、机制、线粒体来源和保存条件、质量控制等方面深入研究。

在自由基相关的天然产物抗氧化机理与衰老和肿瘤关系研究方面有丰富积累。

理论方面重点从线粒体内膜解偶联蛋白表达调控角度探讨自由基与衰老、寿命及肿瘤的关系，实践方面主要从中药天然产物对端粒长度、端粒酶活性、细胞分化、血管生成以及细胞凋亡等方面的影响研究和开发天然产物的生物学活性。

发现啤酒花重要天然产物黄腐酚通过细胞膜NADPH氧化酶刺激活性氧ROS爆发；发现新型微管靶向化合物并获国家发明专利授权。

1      Li Z, Cao X, Liu Z, Wu F, Lin C, Wang CM. Therapeutic effect of mitochondrial transplantation on burn injury[J]. Free Radic Biol Med, 2024, 215: 2-13.

2      王春明. 果蝇杂种劣育与P因子转座调控[J]. 昆虫学报, 2023, 66(07): 959-968.（Wang CM. Hybrid dysgenesis and P-element transposition in Drosophila. Acta Ent Sin, 2023, 66(7): 959-968.）

3      李震, 曹新惠, 王春明. 线粒体移植疗法[J]. 中国细胞生物学学报, 2023, 45(07): 1089-1096. (Li Z, Cao X, Wang C. Mitochondrial transplantation therapy. Chinese Journal of Cell Biology, 2023, 45(7): 1089-1096.)

4      赵晶, 蒲丽平, 陈建军, 王春明. 新型倍半萜-氮芥衍生物的体外抗肿瘤活性及初步构效关系分析[J]. 华西药学杂志, 2023, 38(02): 123-127. (Zhao J, Pu L, Chen J, Wang C. In vitro antitumor activity and preliminary struture – activity relationship analysis of novel sesquiterpene – nitrogen mustard derivatives. WCJPS, 2023, 38(02): 123-127.)

5      Hu SS, Li RY, Cao XH, Liu JJ, Wang ZH, Li Z, Yang ML, Liu JW, Hu LM, Lin CJ, Liu J, Wang CM. Structural integrity is essential for the protective effect of mitochondrial transplantation against UV-induced cell death[J]. J Photochem Photobiol B, 2022. 234: 112534.

6      Wang CM, Chen J, Zhao J, Hu SS, Zhang SQ, Mi XQ, Shi X, Cao XH, Li Z. Xanthohumol Induces ROS through NADPH Oxidase, Causes Cell Cycle Arrest and Apoptosis[J]. Oxid Med Cell Longev, 2021. 2021: 9877170.

7      王春明, 林昌俊, 冯虎元. 遗传漂变教学方法刍议[J]. 遗传, 2020. 42(12): 1211-1220. (Wang C, Lin C, Feng H. How to teach genetic drift[J]. Hereditas (Beijing), 2020. 42(12): 1211-1220.)

8      Wang CM, Huo X, Chen J, Liu JW, Yang TY, Mi XQ, Meng Y, Zhou L, Lin CJ, Liu J. An acute lytic cell death induced by xanthohumol obstructed ROS detecting in HL-60 cells[J]. Toxicol In Vitro, 2020. 62: 104667.

9      王春明, 孙英莉, 林昌俊, 王铭裕, 牛月, 李晓峰, 冯虎元. 粗糙脉孢菌7种子囊型归类教学探究[J]. 遗传, 2019. 41(11): 1067-1072. (Wang C, Sun Y, Lin C, Wang M, Niu Y, Li X, Feng H. How to deduce the seven basic class asci of ordered tetrads in Neurospora[J]. Hereditas (Beijing), 2019.41(11): 1067-1072.)

10    Mi X, Wang C, Sun C, Chen X, Huo X, Zhang Y, Li G, Xu B, Zhang J, Xie J, Wang Z, Li J. Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway[J]. Oncotarget, 2017. 8(19): 31297-31304.

11    王春明. 本科遗传学教学中的遗传漂变概念探讨[J]. 遗传, 2016. 38(1): 82-89. (Wang C. Exploration of the concept of genetic drift in genetics teaching of undergraduates[J]. Hereditas (Beijing), 2016. 38(1): 82-89.)

12    Ru J, Tang X, Ju Z, Zhang G, Dou W, Mi X, Wang C, Liu W. Exploitation and application of a highly sensitive Ru(II) complex-based phosphorescent chemodosimeter for Hg2+ in aqueous solutions and living cells[J]. ACS Appl Mater Interfaces, 2015. 7(7): 4247-56.

13    Ru J, Chen X, Guan L, Tang X, Wang C, Meng Y, Zhang G, Liu W. Ratiometric iridium(III) complex-based phosphorescent chemodosimeter for Hg(2+) applicable in time-resolved luminescence assay and live cell imaging[J]. Anal Chem, 2015. 87(6): 3255-62.

14    Wang J, Pol SU, Haberman AK, Wang C, O'Bara MA, Sim FJ. Transcription factor induction of human oligodendrocyte progenitor fate and differentiation[J]. PNAS, 2014. 111(28): E2885-94.

15    Ru JX, Guan LP, Tang XL, Dou W, Yao X, Chen WM, Liu YM, Zhang GL, Liu WS, Meng Y, Wang CM. Turn-on phosphorescent chemodosimeter for Hg2+ based on a cyclometalated Ir(III) complex and its application in time-resolved luminescence assays and live cell imaging[J]. Inorg Chem, 2014. 53(21): 11498-506.

16    Liu J, Zhou L, Chen JH, Mao W, Li WJ, Hu W, Wang SY, Wang CM. Role of ozone in UV-C disinfection, demonstrated by comparison between wild-type and mutant conidia of Aspergillus niger[J]. Photochem Photobiol, 2014. 90(3): 615-21.

17    Zhang XL, Cao MA, Pu LP, Huang SS, Gao QX, Yuan CS, Wang CM. A novel flavonoid isolated from Sophora flavescens exhibited anti-angiogenesis activity, decreased VEGF expression and caused G0/G1 cell cycle arrest in vitro[J]. Pharmazie, 2013. 68(5): 369-75.

18    Pu LP, Chen HP, Cao MA, Zhang XL, Gao QX, Yuan CS, Wang CM. The antiangiogenic activity of Kushecarpin D, a novel flavonoid isolated from Sophora flavescens Ait[J]. Life Sci, 2013. 93(21): 791-7.

19    Liu J, Li J, Li WJ, Wang CM. The role of uncoupling proteins in diabetes mellitus[J]. J Diabetes Res, 2013. 2013: 585897.

20    郑荣梁, 王春明, 林昌俊, 石益民, 李忌, 赵晨阳, 张琪, 黄双盛, 牟萍, 谭晓荣. DNA瞬态损伤的快速修复阻断癌变最早事件的发展[J]. 生物物理学报, 2012. 28(3): 185-99.

21    Zhao J, Ding HX, Zhao DG, Wang CM, Gao K. Isolation, modification and cytotoxic evaluation of flavonoids from Rhododendron hainanense[J]. J Pharm Pharmacol, 2012. 64(12): 1785-92.

22    王春明, 郑荣梁. 种间对比研究方法阐明解偶联蛋白与最大寿命的关系[J]. 中国老年学杂志, 2011. 31(2): 348-350.

23    史祥, 闫福林, 葛峰, 蒲丽平, 赵晶, 高清祥, 王春明. 七种天然二萜类化合物的体外细胞毒活性及其构效关系[J]. 天然产物研究与开发, 2011. 23(B12): 39-42.

24    Zheng R, Jia Z, Li J, Huang S, Mu P, Zhang F, Wang C, Yuan C. Fast repair of DNA radicals in the earliest stage of carcinogenesis suppresses hallmarks of cancer[J]. RSC Advances, 2011. 1(1): 1610-1619.

25    Wang CM, Almsherqi ZA, McLachlan CS, Matthews S, Ramachandran M, Tay S, Deng Y. Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function[J]. Stress, 2011. 14(1): 66-72.

26    Huang HL, Wang CM, Wang ZH, Yao MJ, Han GT, Yuan JC, Gao K, Yuan CS. Tirucallane-type triterpenoids from Dysoxylum lenticellatum[J]. J Nat Prod, 2011. 74(10): 2235-42.

27    赵晶, 蒲丽平, 杨精涛, 刘权, 高清祥, 王勤, 王春明. 2种苯并呋喃衍生物对肝癌细胞的毒性及活性氧机制[J]. 中国实验方剂学杂志, 2010. 16(16): 105-108.

28    王春明, 陈和平, 郑荣梁. 自由基医学理论用于“治未病”的探讨[J]. 中国预防医学杂志, 2009. 10(7): 685-688.

29    Wang CM, Almsherqi ZA, Slocinska MB, Tan OLL, Cheong YMC, Deng Y. Uncoupling Protein May Contribute to the Much Longer Maximum Life Span Potential of Canary than Mouse, in Proceedings of the XIV Biennial Meeting of the Society for Free Radical Research International. 2008. 147-152.

30    Liu J, Wang GX, Wei L, Wang CM. Reproductive allocation patterns in different density populations of spring wheat[J]. Journal of Integrative Plant Biology, 2008. 50(2): 141-146.

31    Wang CM, Jia ZJ, Zheng RL. The effect of 17 sesquiterpenes on cell viability and telomerase activity in the human ovarian cancer cell line HO-8910[J]. Planta Medica, 2007. 73(2): 180-184.

32    Li PL, Wang CM, Zhanga ZX, Jia ZJ. Five new eremophilane derivatives from Ligularia sagitta[J]. Tetrahedron, 2007. 63(51): 12665-12670.

33    Liu J, Wei L, Wang CM, Wang GX, Wei XP. Effect of water deficit on self-thinning line in spring wheat (Triticum aestivum L.) populations[J]. Journal of Integrative Plant Biology, 2006. 48(4): 415-419.

34    王春明, 郑荣梁. 衰老和癌变过程中自由基与端粒和端粒酶的关系研究进展[J]. 自由基生命科学进展, 2004. 10: 26-31.

35    Wu QH, Wang CM, Cheng SG, Gao K. Bieremoligularolide and eremoligularin, two novel sesquiterpenoids from Ligularia muliensis[J]. Tetrahedron Letters, 2004. 45(48): 8855-8858.

36    Wang CM, Hua W, We YM, Jia ZJ, Zheng RL. In vitro effects on proliferation, telomerase activity and apoptosis of an eremophilanoid sesquiterpene from Senecio oldhamianus Maxim in cultured human tumor cell lines[J]. Pharmazie, 2004. 59(10): 802-806.

37    Min Y, Wang CM, Qi Z, Han YF, Jia ZJ. Sesquiterpenes, lignans and other constituents from Saussurea macrota[J]. Pharmazie, 2004. 59(12): 972-976.

38    Yang C, Wang CM, Jia ZJ. Sesquiterpenes and other constituents from the aerial parts of Inula japonica[J]. Planta Medica, 2003. 69(7): 662-666.

39    Wang WS, Gao K, Wang CM, Jia ZJ. Cytotoxic triterpenes from Liguladopsis shichuana[J]. Pharmazie, 2003. 58(2): 148-150.

40    王春明, 陈兴, 王瑛, 贾忠建, 郑荣梁. 离舌橐吾中3种倍半萜的体外抗癌活性[J]. 兰州大学学报(自然科学版), 2002. 38(6): 123-124.

41    Yang H, Wang CM, Jia ZJ, Shi YP. Four new eremophilanoid sesquiterpenes from Senecio oldhamianus[J]. Acta Chimica Sinica, 2001. 59(10): 1686-1690.

参编著作：

1. 王春明, 郑荣梁, 王振华: 还原压力. In: 自由基生物医学. Edited by 郑荣梁, 魏耀挥, 赵崇义, 黄中洋, 陈建村, vol. 1. 台湾: 逸轩图书出版社; 2013: 73-94.
2. 王春明: 缺氧复氧性损伤. In: 自由基生物医学. Edited by 郑荣梁, 魏耀挥, 赵崇义, 黄中洋, 陈建村. 台湾: 逸轩图书出版社; 2013: 451-466.
3. 王春明: 自由基与端粒和端粒酶. In: 自由基毒理学. Edited by 柯跃斌, 郑荣梁. 北京: 人民卫生出版社; 2012: 333-340.
4. 王春明, 刘恒: 脂质体的制备. In: 细胞生物学实验. Edited by 王崇英, 高清祥, 3rd edn. 北京: 高等教育出版社; 2011: 85-89.
5. 王春明, 高清祥, 易娟: 动物细胞周期检测. In: 细胞生物学实验. Edited by 王崇英, 高清祥, 3rd edn. 北京: 高等教育出版社; 2011: 173-175.
6. 常城, 王春明: 缺血再灌注损伤的自由基机制. In: 自由基生物学. Edited by 郑荣梁, 黄中洋, vol. 第三版. 北京: 高等教育出版社; 2007: 260-266.