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巢细娟

个人简历

科研成果

教学情况

研究方向

荣誉奖励

论文专著

其他信息

个人简历

基本信息

职称:青年研究员

办公室地址:天演楼437

邮箱:chaoxj@lzu.edu.cn

学习经历


2009.09-2015.12 中科院生态环境研究中心,环境科学专业,理学博士,导师:朱本占研究员

2004.09-2009.07 南昌大学(公共卫生学院),预防医学专业,本科


工作经历


2019.04-至今,兰州大学,生命科学学院,青年研究员

2016.09-2019.03 中山大学,化学学院,副研究员


社会工作

科研成果

国家自然科学青年基金,主持 (2021,01-2023,12)

中央高校基本科研业务费-优秀青年教师,主持 (2021.01-2022.12)

兰州大学“双一流”科研启动经费, 主持

广东省自然科学基金:小分子促进细胞膜非通透性金属配合物细胞核的摄取及抗肿瘤机理研究,主持

国家自然科学基金重点项目:基于溶液结构的四链体核酸功能的铂配合物调控,参与

国家自然科学基金重点项目:有机农药与含铜、锌无机农药的协同毒性作用机理研究,参与

国家自然科学基金创新群体项目:持久性有毒污染物的环境过程与毒理效应,参与

广东省自然科学基金:G-四链体靶向的无机-有机杂化多核铂(II)配合物选择性诱导癌细胞端粒功能障碍的研究,参与

教学情况

独立指导硕士研究生两名:陈楚萱同学获得甘肃省2022年度优秀研究生“创新之星”项目;



欢迎对细胞荧光成像,毒理学及药物治疗等相关研究感兴趣的同学报考

研究方向

包括毒理学研究;金属配合物的潜在抗癌效应及光动力学治疗方面的研究;细胞荧光成像。

荣誉奖项

第十届挑战杯南昌大学大学生课外学术科技作品竞赛二等奖

2004-2005学年度一等优秀学生奖学金

2005年全国大学生英语竞赛三等奖

2005年度雷大贞医学教育奖学金

2005-2006学年度 一、二学期一等优秀学生奖学金及三好学生标兵

2006年度二等汇仁奖学金

2006-2007学年度 一、二学期特等优秀学生奖学金及三好学生标兵

2006-2007学年度国家励志奖学金

2007年度雷大贞医学教育奖学金

2007-2008学年度国家励志奖学金

2007-2008学年度中兴发展奖学金一等奖

2007-2008学年一、二学期特等优秀学生奖学金及三好学生标兵

2008-2009特等优秀学生奖学金

2009届南昌大学优秀毕业生称号

2011-2012中国科学院大学三好学生称号

2012-2013中国科学院大学三好学生称号

2013-2014中国科学院大学三好学生称号

2014-2015中国科学院大学三好学生称号

论文专著

1. Chao XJ*, Yao DZ, Chen CX, Zhang CF. (2022) An efficient human serum albumin-assisted fluorescence approach for hemin detection. Environmental Technology & Innovation, 29, 102969.

2. Chao XJ*, Yao DZ, Qi YM, Cong Y, Huang DJ. (2021) A fluorescent sensor recognized by the FA1 site for highly sensitive detection of HSA. Analytica Chimica Acta,1188,339201.

3. Chao XJ*, Qi YM, Zhang YM*. (2021) Highly Photostable Fluorescent Tracker with pH-Insensitivity for Long-Term Imaging of Lysosomal Dynamics in Live Cells. ACS Sensors,6,3,786-796. (Inside Cover)

4. Chao XJ*, Hu Y, Liu RJ, Huang DJ, Zhang YM*. (2021) Near-infrared ratiometric fluorescence imaging of lysosomal polarity in live cells and in vivo. Sensors and Actuators: B. Chemical,345, 13039.

5. Chao XJ, Tang M, Huang R, Huang C-H,Shao J, Yan ZY and Zhu BZ*. (2019) Targeted live-cell nuclear delivery of the DNA ‘light-switching’ Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes. Nucleic Acids Research, 47,20,10520-10528.

6. Chao XJ#, Pan ZY#, Sun LL, Tang M, Wang KN, Mao Z -W*. (2019) A pH-insensitive near-infrared fluorescent tracker for wash-free lysosome-specific imaging with long time under physiological and pathological processes. Sensors and actuators B-Chemical,285,156-163.

7. Chao XJ#, Wang KN#, Sun LL, Cao Q, Ke ZF, Cao DX, Mao Z -W*. (2018) Cationic organochalcogen with monomer/excimer emission for dual-color live cell imaging and cell damage diagnosis. ACS Applied Materials and Interfaces,10, 13264-13273.

8. Wang KN#, Chao XJ#, Liu B, Zhou DJ, He L, Zheng XH, Cao Q, Tan CP, Zhang C, Mao Z -W*. (2018) Red fluorescent probes for real-time imaging of the cell cycle by dynamic monitoring of the nucleolus and chromosome. Chemical Communication,54,2635-2638.

9. Zhu BZ*, Chao XJ, Huang C-H and Li Y. (2016) Delivering the cell-impermeable DNA ‘Light-switching’ Ru(II) complexes into the nucleus of living cells via ion-pairing. Chemical Science, 7, 4016-4023. (导师一作)

10. Wang KN#, Liu LY#, Qi GB, Chao XJ, Ma W, Yu ZQ*, Pan QL, Mao Z -W*, Liu B*, (2021) Light-driven cascade mitochondria-to-nucleus photosensitization in cancer cell ablation. Advanced Science, 8, 2004379.

11.Sheng ZG, Shen C, Fan RM, Chao XJ, Liu YX, Zhu BZ. (2019) The Critical Role of X Chromosome-Linked Inhibitor of Apoptosis (XIAP) in Differential Synergism Induced by Pentachlorophenol and Copper-1,10-Phenanthroline Complex in Normal and Cancer Liver Cells. Toxicol Sci.168, 339.

12.Yongmei Qi, Lin Ma, Sajid Naeem, Xueyan Gu, Xijuan Chao, Cong Yuan, Dejun Huang*. Pb induced mitochondrial fission of fibroblast cells via ATM activation. Journal of Hazardous Materials, 2021, 416: 126177.

13. Huang R, Tang M, Huang CH, Chao XJ, Yan ZY, Shao J,Zhu BZ. (2019) What are the major physicochemical factors in determining the preferential nuclear uptake of the DNA "Light-Switching" Ru(II)-polypyridyl complex in live cells via ion-pairing with chlorophenolate counter-Anions? J. Phys. Chem. Lett., 10, 4123-4128.

14. Zhu BZ*, Chao XJ. (2016) Redirecting Ru(II)-complex into live-cell nucleus for enantioselective DNA-imaging and photosensitizing via simple Yin-Yang ion-pairing. Free Radical Biology and Medicine,100, S33-S34. (摘要论文)

15. Wang KN, Sun PZ, Chao XJ, Cao DX*, Mao Z -W*, Zhiqiang Liu*. (2018) A coumarin Schiff's base two-photon fluorescent probe for hypochlorite in living cells and zebrafish. RSC advances,8, 6904-6909.

16. Sheng ZG, Shen C, Fan RM, Chao XJ, Liu YX, Zhu BZ*. (2018) The Critical Role of X Chromosome-linked Inhibitor of Apoptosis (XIAP) in Differential Synergism Induced by Pentachlorophenol and Copper-1,10-phenanthroline Complex in Normal and Cancer Liver Cells. Toxicol. Sci.,0, 1-10.

17. Sheng ZG, Li Y, Fan RM, Chao XJ, Zhu BZ*. (2013) Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex. Toxicol. Appl. Pharmacol.,266, 335-344.

18. Sheng ZG, Tang Y, Liu YX, Yuan Y, Zhao BQ, Chao XJ, Zhu BZ*. (2012) Low concentrations of bisphenol A suppress thyroid hormone receptor transcription through a nongenomic mechanism. Toxicol. Appl. Pharmacol.,259, 133-142.

19. 朱本占*,肖璇,巢细娟,唐苗,黄蓉, 邵杰。(2018) DNA分子“光开关”含钌多吡啶络合物细胞摄取、胞内分布及毒性机理研究。Progress in Chemistry,30, 1975-1991.

20. 专利:朱本占,巢细娟,一种促进Ru(II)金属络合物细胞核摄取的方法。 专利号:201510531733.2

其他信息

会议及口头报告:

第六届全国环境大会

第八届全国环境大会 10分钟口头报告

第十四次中国暨国际生物物理大会 15分钟口头报告

第十七次国际生物无机化学大会

8th Asian Biological Inorganic Chemistry Conference, in New Zealand

最新更新时间: 2022-10-19